SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 ALA A 297
VAL A  47
TRP A 393
 None
 0.87A 1grmA-5omsA:
undetectable		 1grmA-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 ALA A 297
VAL A  47
TRP A 393
 None
 0.87A 1grmB-5omsA:
undetectable		 1grmB-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 ALA A 297
VAL A  47
TRP A 393
 None
 0.92A 1jo4A-5omsA:
undetectable		 1jo4A-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 ALA A 297
VAL A  47
TRP A 393
 None
 0.92A 1jo4B-5omsA:
undetectable		 1jo4B-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 ALA A 297
VAL A  47
TRP A 393
 None
 0.94A 1magA-5omsA:
undetectable		 1magA-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 ALA A 297
VAL A  47
TRP A 393
 None
 0.94A 1magB-5omsA:
undetectable		 1magB-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 GLN A 267
HIS A 340
ARG A 280
 None
 1.09A 1zlqA-5omsA:
undetectable		 1zlqA-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 GLY A 185
GLU A 188
ASN A 182
 None
 0.68A 1zq9A-5omsA:
undetectable		 1zq9A-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 ALA A  79
ILE A  80
ALA A 295
LEU A 319
ILE A 292
 None
HEM  A 501 (-4.4A)
261  A 502 ( 3.9A)
None
HEM  A 501 ( 3.5A)
 0.95A 2h42B-5omsA:
undetectable		 2h42B-5omsA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		4 / 7 PHE A  63
THR A 315
VAL A 309
VAL A  53
 None
 0.87A 2qbnA-5omsA:
38.8		 2qbnA-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 LEU A 286
HIS A 346
PHE A 349
ARG A 367
PRO A 279
 None
None
HEM  A 501 (-4.6A)
None
None
 1.12A 2xpwA-5omsA:
undetectable		 2xpwA-5omsA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 9 ILE A 235
ILE A 216
PRO A 237
ILE A  80
VAL A 112
 None
None
None
HEM  A 501 (-4.4A)
None
 1.29A 2ygpA-5omsA:
undetectable		 2ygpA-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 10 PRO A 398
THR A 257
VAL A 132
GLY A 253
GLY A 251
 None
 0.85A 3ixlA-5omsA:
undetectable		 3ixlA-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 HIS A 354
ARG A 298
GLU A  64
 HEM  A 501 (-3.8A)
HEM  A 501 (-2.9A)
None
 1.16A 3qf1A-5omsA:
undetectable		 3qf1A-5omsA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 LEU A 286
HIS A 346
PHE A 349
ARG A 367
PRO A 279
 None
None
HEM  A 501 (-4.6A)
None
None
 1.05A 4b3aA-5omsA:
undetectable		 4b3aA-5omsA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 ARG A  32
THR A 289
TRP A 293
 None
 1.09A 4d7hA-5omsA:
undetectable		 4d7hA-5omsA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 GLU A 389
VAL A 388
PRO A 398
THR A 170
GLY A 394
 None
 1.48A 4hvcA-5omsA:
undetectable		 4hvcA-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 GLU A 389
VAL A 388
PRO A 398
THR A 170
GLY A 394
 None
 1.46A 4olfA-5omsA:
undetectable		 4olfA-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 ARG A  32
THR A 289
TRP A 293
 None
 1.04A 4ug5A-5omsA:
undetectable		 4ug5A-5omsA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 ARG A  32
THR A 289
TRP A 293
 None
 1.03A 4uglA-5omsA:
undetectable		 4uglA-5omsA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		4 / 6 ILE A 278
PRO A 279
ILE A 108
VAL A 112
 None
 0.99A 4zj8A-5omsA:
undetectable		 4zj8A-5omsA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 ARG A 385
THR A 404
ASP A 383
 None
 0.92A 5g5gA-5omsA:
undetectable
5g5gB-5omsA:
undetectable		 5g5gA-5omsA:
undetectable
5g5gB-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 ARG A  32
THR A 289
TRP A 293
 None
 1.09A 5g6cA-5omsA:
undetectable		 5g6cA-5omsA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		3 / 3 LEU A  43
TYR A  28
SER A 294
 None
 0.64A 5iktA-5omsA:
undetectable		 5iktA-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		4 / 6 LEU A 258
SER A 263
ARG A 264
GLY A 260
 None
 1.10A 5o4yF-5omsA:
undetectable		 5o4yF-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 10 ALA A 255
LEU A 258
VAL A 259
LEU A 373
GLU A 137
 None
 0.89A 5v02B-5omsA:
undetectable
5v02R-5omsA:
undetectable		 5v02B-5omsA:
undetectable
5v02R-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		4 / 7 VAL A 141
VAL A 365
PRO A 250
GLY A 251
 None
None
HEM  A 501 (-3.7A)
None
 0.75A 5x80C-5omsA:
undetectable
5x80D-5omsA:
undetectable		 5x80C-5omsA:
19.38
5x80D-5omsA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 GLU A 389
VAL A 388
PRO A 398
THR A 170
GLY A 394
 None
 1.31A 5xiqD-5omsA:
undetectable		 5xiqD-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		4 / 8 ILE A 196
LEU A 165
ALA A 246
LEU A 144
 None
None
261  A 502 ( 3.5A)
None
 0.81A 5y7pE-5omsA:
undetectable		 5y7pE-5omsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 VAL A  53
GLU A  52
LEU A   9
LEU A  12
ALA A 307
 None
 0.93A 6ew0B-5omsA:
undetectable		 6ew0B-5omsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 VAL A  53
GLU A  52
LEU A   9
LEU A  12
ALA A 307
 None
 0.94A 6ew0D-5omsA:
undetectable		 6ew0D-5omsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 VAL A  53
GLU A  52
LEU A   9
LEU A  12
ALA A 307
 None
 0.93A 6ew0H-5omsA:
undetectable		 6ew0H-5omsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 12 VAL A  53
GLU A  52
LEU A   9
LEU A  12
ALA A 307
 None
 0.93A 6ew0I-5omsA:
undetectable		 6ew0I-5omsA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		5 / 10 MET A 318
GLY A 394
ARG A 396
TRP A 393
GLY A 322
 None
 1.38A 6hqbA-5omsA:
undetectable
6hqbJ-5omsA:
undetectable		 6hqbA-5omsA:
20.69
6hqbJ-5omsA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5oms CYTOCHROME P450
(Amycolatopsis
sp.
ATCC
39116) 		4 / 6 ARG A  73
ALA A  70
THR A  74
ALA A 187
 None
 1.01A 6ma6A-5omsA:
27.9		 6ma6A-5omsA:
19.10