SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ons'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 5ons DENSITY-REGULATED
PROTEIN
MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1
(Homo
sapiens) 		4 / 6 LEU A 170
ILE A 102
GLU B  45
PRO B  40
 None
 0.99A 1ditH-5onsA:
undetectable
1ditP-5onsA:
undetectable		 1ditH-5onsA:
14.46
1ditP-5onsA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 5ons MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1
DENSITY-REGULATED
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		5 / 10 VAL A  97
LEU A 143
LEU A 106
TYR B  46
ALA A 101
 None
 1.35A 1pbcA-5onsA:
undetectable		 1pbcA-5onsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5ons MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1
(Homo
sapiens) 		4 / 7 ILE A  15
LEU A  29
ILE A  43
ILE A  91
 None
None
GOL  A 203 (-4.5A)
None
 0.89A 1uwjA-5onsA:
undetectable		 1uwjA-5onsA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 5ons MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1
(Homo
sapiens) 		5 / 12 PHE A   5
LEU A 174
CYH A  55
LEU A  29
LEU A  92
 None
 1.13A 2hc4A-5onsA:
undetectable		 2hc4A-5onsA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 5ons MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1
(Homo
sapiens) 		5 / 9 GLU A  75
GLN A  32
ARG A  72
PHE A  78
LEU A  62
 None
 1.43A 3mjrA-5onsA:
undetectable		 3mjrA-5onsA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 5ons MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1
(Homo
sapiens) 		4 / 7 VAL A 158
GLY A 161
ILE A 162
VAL A 128
 None
 0.82A 3ufnB-5onsA:
undetectable		 3ufnB-5onsA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 5ons MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1
(Homo
sapiens) 		4 / 5 TYR A  88
LYS A  87
LEU A  69
GLU A  67
 None
GOL  A 203 ( 4.4A)
GOL  A 203 (-4.6A)
GOL  A 203 (-3.6A)
 1.49A 4olbA-5onsA:
undetectable		 4olbA-5onsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 5ons DENSITY-REGULATED
PROTEIN
MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1
(Homo
sapiens) 		4 / 5 HIS A 176
HIS A  86
LEU B  32
VAL B  31
 None
 1.05A 6bc9A-5onsA:
undetectable		 6bc9A-5onsA:
15.29