SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ook'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT
(Acaryochloris
marina;
Acaryochloris
marina) 		5 / 11 ALA A 101
ASP B   3
LEU A   5
TYR A 165
THR B   6
 None
None
None
PEG  A 204 (-4.5A)
None
 1.22A 1jomA-5ookA:
undetectable		 1jomA-5ookA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ook PHYCOCYANIN, ALPHA
SUBUNIT
(Acaryochloris
marina) 		4 / 4 ALA A  52
VAL A  85
ALA A  56
HIS A 135
 None
 1.16A 1q23F-5ookA:
undetectable		 1q23F-5ookA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT
(Acaryochloris
marina) 		5 / 10 ALA A 101
ASP B   3
LEU A   5
TYR A 165
THR B   6
 None
None
None
PEG  A 204 (-4.5A)
None
 1.28A 1rb3A-5ookA:
undetectable		 1rb3A-5ookA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_B_MTXB170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT
(Acaryochloris
marina) 		5 / 10 ALA A 101
ASP B   3
LEU A   5
TYR A 165
THR B   6
 None
None
None
PEG  A 204 (-4.5A)
None
 1.33A 1tdrB-5ookA:
undetectable		 1tdrB-5ookA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT
(Acaryochloris
marina) 		5 / 12 THR B  45
ALA B  98
THR B 101
VAL A   9
GLN A  15
 None
 1.06A 2ve3A-5ookB:
undetectable		 2ve3A-5ookB:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 5ook PHYCOCYANIN, ALPHA
SUBUNIT
(Acaryochloris
marina) 		3 / 3 GLU A   7
ASP A 108
TYR A 168
 PEG  A 202 (-2.9A)
None
None
 0.86A 2yvlB-5ookA:
undetectable		 2yvlB-5ookA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT
(Acaryochloris
marina) 		4 / 8 THR B   6
ILE A   6
VAL A   9
GLY B 102
 None
 0.85A 4eq4B-5ookB:
undetectable		 4eq4B-5ookB:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)		 5ook PHYCOCYANIN, ALPHA
SUBUNIT
(Acaryochloris
marina) 		4 / 6 SER A  10
ASP A  13
ARG A  17
GLU A  23
 None
 1.26A 4eysA-5ookA:
undetectable		 4eysA-5ookA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT
(Acaryochloris
marina;
Acaryochloris
marina) 		5 / 11 ALA A 101
ASP B   3
LEU A   5
TYR A 165
THR B   6
 None
None
None
PEG  A 204 (-4.5A)
None
 1.27A 4i1nA-5ookA:
undetectable		 4i1nA-5ookA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_A_SAMA301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT
(Acaryochloris
marina;
Acaryochloris
marina) 		5 / 12 GLY B 102
ARG B  37
ILE A 100
LYS B  28
LEU B  27
 None
 1.14A 5bw4A-5ookB:
undetectable		 5bw4A-5ookB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT
(Acaryochloris
marina;
Acaryochloris
marina) 		4 / 7 SER A 164
GLY A 102
ALA A 101
VAL B  19
 PEG  A 204 (-3.5A)
None
None
None
 0.85A 6dwnB-5ookA:
undetectable		 6dwnB-5ookA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 5ook PHYCOCYANIN, ALPHA
SUBUNIT
PHYCOCYANIN, BETA
SUBUNIT
(Acaryochloris
marina;
Acaryochloris
marina) 		5 / 11 GLY B 102
LEU A   5
ALA A  27
ALA B  34
PHE A  31
 None
 1.13A 6qgbE-5ookB:
undetectable		 6qgbE-5ookB:
undetectable