SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ool'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A52_A_ESTA1_1
(ESTROGEN RECEPTOR)		 5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA 6 198
GLU 6 197
ILE 6 265
HIS 6 266
LEU 6 268
 None
 1.39A 1a52A-5ool6:
undetectable		 1a52A-5ool6:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5ool 39S RIBOSOMAL
PROTEIN L9,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 VAL H 102
VAL H 114
ILE H  97
ALA H 129
LEU H 123
 None
 1.18A 1eqgA-5oolH:
undetectable		 1eqgA-5oolH:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP d 183
GLU d 244
ILE d 146
LEU d 222
 None
 1.42A 1q0yH-5oold:
undetectable
1q0yL-5oold:
undetectable		 1q0yH-5oold:
18.44
1q0yL-5oold:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 5ool 39S RIBOSOMAL
PROTEIN L46,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU e 173
ALA e  50
LEU e  53
GLN e  54
HIS e 212
 None
 1.37A 1rbpA-5oole:
undetectable		 1rbpA-5oole:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5ool 39S RIBOSOMAL
PROTEIN L46,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE e 234
PHE e 204
ARG e 190
ALA e 236
 None
 1.04A 1rqpC-5oole:
undetectable		 1rqpC-5oole:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5ool 39S RIBOSOMAL
PROTEIN L46,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE e 234
PHE e 204
ARG e 190
ALA e 236
 None
 1.00A 1rqpA-5oole:
undetectable		 1rqpA-5oole:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU 5 113
ILE 5 314
THR 5 126
ILE 5 262
LEU 5 265
 None
 1.03A 1tw4B-5ool5:
undetectable		 1tw4B-5ool5:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L41,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L24,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens;
Homo
sapiens) 		3 / 3 ASP 5  84
GLU 9  55
TYR V 210
 C  A1707 ( 4.6A)
None
None
 0.75A 1wsvA-5ool5:
undetectable		 1wsvA-5ool5:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ool 39S RIBOSOMAL
PROTEIN L44,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU c 257
GLY c 284
TYR c 270
ALA c 296
ALA c 297
 None
 1.13A 2br4F-5oolc:
undetectable		 2br4F-5oolc:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU 5 382
TYR 5 383
ILE 5 158
ARG 5 173
 None
None
None
A  A2395 ( 3.0A)
 0.95A 2du8A-5ool5:
undetectable		 2du8A-5ool5:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU 5 382
TYR 5 383
ILE 5 158
ARG 5 173
 None
None
None
A  A2395 ( 3.0A)
 0.95A 2du8B-5ool5:
undetectable		 2du8B-5ool5:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 5ool 39S RIBOSOMAL
PROTEIN L42,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L44,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG c 259
GLU c 283
ILE a  67
PRO a  68
 None
 1.03A 2fcnA-5oolc:
undetectable
2fcnB-5oolc:
undetectable		 2fcnA-5oolc:
12.89
2fcnB-5oolc:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 5ool 39S RIBOSOMAL
PROTEIN L14,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS L  31
GLY L  93
PRO L  94
 A  A2469 ( 3.8A)
None
None
 0.94A 2hreB-5oolL:
undetectable		 2hreB-5oolL:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 5ool 39S RIBOSOMAL
PROTEIN L41,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS 9  15
GLY 9  26
PRO 9  27
 None
G  A2339 ( 4.6A)
G  A2339 ( 3.8A)
 0.88A 2hreB-5ool9:
undetectable		 2hreB-5ool9:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG 5 162
ARG 5 350
ARG 5 173
 A  A2394 ( 3.7A)
A  A2395 ( 3.1A)
A  A2395 ( 3.0A)
 1.17A 2jb7A-5ool5:
undetectable
2jb7B-5ool5:
undetectable
2jb7C-5ool5:
undetectable		 2jb7A-5ool5:
18.03
2jb7B-5ool5:
18.03
2jb7C-5ool5:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG 5 173
ARG 5 162
ARG 5 350
 A  A2395 ( 3.0A)
A  A2394 ( 3.7A)
A  A2395 ( 3.1A)
 1.15A 2jb7A-5ool5:
undetectable
2jb7B-5ool5:
undetectable
2jb7C-5ool5:
undetectable		 2jb7A-5ool5:
18.03
2jb7B-5ool5:
18.03
2jb7C-5ool5:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG 5 350
ARG 5 173
ARG 5 162
 A  A2395 ( 3.1A)
A  A2395 ( 3.0A)
A  A2394 ( 3.7A)
 1.17A 2jb7A-5ool5:
undetectable
2jb7B-5ool5:
undetectable
2jb7C-5ool5:
undetectable		 2jb7A-5ool5:
18.03
2jb7B-5ool5:
18.03
2jb7C-5ool5:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU 5 113
ILE 5 314
THR 5 126
ILE 5 262
LEU 5 265
 None
 1.14A 2jn3A-5ool5:
undetectable		 2jn3A-5ool5:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)		 5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG 6 364
GLN 6 361
PRO 6 362
 A  A2858 ( 3.5A)
None
None
 0.99A 2qhfA-5ool6:
undetectable		 2qhfA-5ool6:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5ool 39S RIBOSOMAL
PROTEIN L24,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP V  60
LEU V  56
ILE V 133
ARG V 145
 None
 0.98A 2qqdA-5oolV:
undetectable
2qqdE-5oolV:
undetectable		 2qqdA-5oolV:
11.22
2qqdE-5oolV:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_D_RIMD499_1
(MATRIX PROTEIN 2)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE 5 314
ARG 5 310
LEU 5 355
LEU 5 121
 None
 1.00A 2rlfA-5ool5:
undetectable
2rlfD-5ool5:
undetectable		 2rlfA-5ool5:
7.22
2rlfD-5ool5:
7.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5ool 39S RIBOSOMAL
PROTEIN L46,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE e 234
PHE e 204
ARG e 190
ALA e 236
 None
 0.98A 2v7uA-5oole:
undetectable		 2v7uA-5oole:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TYR 5 176
ILE 5 180
GLY 5 349
LEU 5 381
 None
 0.94A 2vctD-5ool5:
undetectable		 2vctD-5ool5:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU 6 236
GLN 6 275
THR 6 238
THR 6 300
 None
 1.28A 2zj0B-5ool6:
undetectable		 2zj0B-5ool6:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU 6 236
GLN 6 275
THR 6 238
THR 6 300
 None
 1.39A 2zj0C-5ool6:
undetectable		 2zj0C-5ool6:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 LEU 6 236
GLN 6 275
THR 6 238
THR 6 300
 None
 1.33A 2zj0D-5ool6:
undetectable		 2zj0D-5ool6:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 LEU 6 236
GLN 6 275
THR 6 238
THR 6 300
 None
 1.36A 3ce6B-5ool6:
undetectable		 3ce6B-5ool6:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE 5 256
LEU 5 265
ASP 5 264
LEU 5 123
ILE 5 262
 None
None
U  A2387 ( 3.8A)
None
None
 1.24A 3ko0M-5ool5:
0.5
3ko0N-5ool5:
0.5
3ko0O-5ool5:
0.2
3ko0P-5ool5:
0.5		 3ko0M-5ool5:
12.80
3ko0N-5ool5:
12.80
3ko0O-5ool5:
12.80
3ko0P-5ool5:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5ool 39S RIBOSOMAL
PROTEIN L46,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 THR e 191
GLN e 179
ALA e 188
GLY e 186
THR e 183
 None
 1.34A 3mg0H-5oole:
undetectable
3mg0I-5oole:
undetectable		 3mg0H-5oole:
21.59
3mg0I-5oole:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 5ool 39S RIBOSOMAL
PROTEIN L35,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		3 / 3 LYS 6 355
ARG 6 368
LYS 3 126
 None
G  A2860 ( 2.9A)
A  A2869 ( 3.4A)
 1.40A 3okxA-5ool6:
undetectable		 3okxA-5ool6:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 PHE d 228
TYR d 178
ILE d 276
LEU d 277
 None
 1.13A 3sudA-5oold:
undetectable		 3sudA-5oold:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE d 228
TYR d 178
ILE d 276
LEU d 277
 None
 1.00A 3sueC-5oold:
undetectable		 3sueC-5oold:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 TYR d 245
VAL d 195
HIS d 193
THR d 213
 None
 1.09A 3tj7A-5oold:
undetectable
3tj7B-5oold:
undetectable		 3tj7A-5oold:
21.02
3tj7B-5oold:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 TYR d 245
VAL d 195
HIS d 193
THR d 213
 None
 1.10A 3tj7C-5oold:
undetectable
3tj7D-5oold:
undetectable		 3tj7C-5oold:
21.02
3tj7D-5oold:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 VAL d 195
HIS d 193
THR d 213
TYR d 245
 None
 1.14A 3tj7C-5oold:
undetectable
3tj7D-5oold:
undetectable		 3tj7C-5oold:
21.02
3tj7D-5oold:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG 6 150
TRP 6 139
GLY 6 144
 None
 0.94A 4e7cA-5ool6:
undetectable		 4e7cA-5ool6:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS 5 172
TYR 5 176
ARG 5 173
 U  A2392 ( 4.1A)
None
A  A2395 ( 3.0A)
 1.27A 4gc9A-5ool5:
undetectable		 4gc9A-5ool5:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7U_D_YTZD802_1
(SEPIAPTERIN
REDUCTASE)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU 5 187
CYH 5 188
PHE 5 411
TYR 5 418
 None
 1.22A 4j7uD-5ool5:
undetectable		 4j7uD-5ool5:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU 5 113
GLY 5 116
ASP 5 307
ILE 5 314
LEU 5 121
 None
 1.20A 4o5fA-5ool5:
undetectable
4o5fB-5ool5:
undetectable		 4o5fA-5ool5:
21.16
4o5fB-5ool5:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU 5 121
LEU 5 113
GLY 5 116
ASP 5 307
ILE 5 314
 None
 1.21A 4o5fA-5ool5:
undetectable
4o5fB-5ool5:
undetectable		 4o5fA-5ool5:
21.16
4o5fB-5ool5:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU 5 198
HIS 5 420
LEU 5 419
ALA 5 422
HIS 5 289
 None
 1.10A 4p65A-5ool5:
undetectable
4p65B-5ool5:
undetectable
4p65F-5ool5:
undetectable
4p65H-5ool5:
undetectable		 4p65A-5ool5:
4.70
4p65B-5ool5:
6.42
4p65F-5ool5:
6.42
4p65H-5ool5:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU 5 198
HIS 5 420
LEU 5 419
ALA 5 422
HIS 5 289
 None
 1.05A 4p65C-5ool5:
undetectable
4p65D-5ool5:
undetectable
4p65J-5ool5:
undetectable
4p65L-5ool5:
undetectable		 4p65C-5ool5:
4.70
4p65D-5ool5:
6.42
4p65J-5ool5:
6.42
4p65L-5ool5:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU 5 198
HIS 5 420
LEU 5 419
ALA 5 422
HIS 5 289
 None
 0.97A 4p65E-5ool5:
undetectable
4p65F-5ool5:
undetectable
4p65J-5ool5:
undetectable
4p65L-5ool5:
undetectable		 4p65E-5ool5:
4.70
4p65F-5ool5:
6.42
4p65J-5ool5:
6.42
4p65L-5ool5:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5ool 39S RIBOSOMAL
PROTEIN L46,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLN e  54
LEU e 238
CYH e  52
ALA e 176
ALA e 188
 None
 1.36A 4pclB-5oole:
undetectable		 4pclB-5oole:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 PHE 5 354
VAL 5 181
TYR 5 292
PHE 5 352
GLY 5 346
 None
 1.38A 4xp1A-5ool5:
undetectable		 4xp1A-5ool5:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XPB_A_COCA702_1
(TRANSPORTER)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 PHE 5 354
VAL 5 181
TYR 5 292
PHE 5 352
GLY 5 346
 None
 1.40A 4xpbA-5ool5:
undetectable		 4xpbA-5ool5:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU 5 113
GLY 5 116
ASP 5 307
ILE 5 314
LEU 5 121
 None
 1.22A 5b8hA-5ool5:
undetectable
5b8hB-5ool5:
undetectable		 5b8hA-5ool5:
20.92
5b8hB-5ool5:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU 5 121
LEU 5 113
GLY 5 116
ASP 5 307
ILE 5 314
 None
 1.22A 5b8hA-5ool5:
undetectable
5b8hB-5ool5:
undetectable		 5b8hA-5ool5:
20.92
5b8hB-5ool5:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5ool 39S RIBOSOMAL
PROTEIN L24,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		4 / 6 LYS d 207
TYR d 209
GLY V  90
GLU V 112
 None
 1.15A 5emlA-5oold:
undetectable		 5emlA-5oold:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 MET d  57
GLN d  58
ARG d  61
 None
 0.99A 5ewzB-5oold:
undetectable		 5ewzB-5oold:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PHE 5 352
VAL 5 181
ILE 5 185
ILE 5 147
 None
 0.94A 5hw8H-5ool5:
undetectable		 5hw8H-5ool5:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LYS 5 233
ASP 5 234
ARG 5 201
 None
 0.70A 5jwaA-5ool5:
undetectable
5jwaH-5ool5:
undetectable		 5jwaA-5ool5:
19.44
5jwaH-5ool5:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 MET d  57
GLN d  58
ARG d  61
 None
 1.01A 5m35B-5oold:
undetectable		 5m35B-5oold:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 MET d  57
GLN d  58
ARG d  61
 None
 1.04A 5m36A-5oold:
undetectable		 5m36A-5oold:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ool 39S RIBOSOMAL
PROTEIN L24,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 THR d 263
THR V 107
LEU d  78
 None
 0.70A 5m66D-5oold:
undetectable		 5m66D-5oold:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5ool 39S RIBOSOMAL
PROTEIN L44,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE c 215
VAL c 169
VAL c 165
PHE c 195
GLN c 192
 None
 1.17A 5n0sB-5oolc:
undetectable		 5n0sB-5oolc:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 THR 5 347
ASP 5 295
ARG 5 173
LEU 5 294
 None
None
A  A2395 ( 3.0A)
None
 1.44A 5tdmA-5ool5:
undetectable		 5tdmA-5ool5:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDM_A_ADNA904_1
(ATP-CITRATE SYNTHASE)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 THR 5 347
ASP 5 348
ARG 5 173
LEU 5 294
 None
None
A  A2395 ( 3.0A)
None
 1.30A 5tdmA-5ool5:
undetectable		 5tdmA-5ool5:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE 5 318
PHE 5 107
LEU 5 123
LEU 5 355
 None
 1.07A 5veuH-5ool5:
undetectable		 5veuH-5ool5:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ool 39S RIBOSOMAL
PROTEIN L44,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLN c 177
PHE c  92
LEU c  88
PHE c  83
 None
 1.05A 5z84P-5oolc:
undetectable
5z84W-5oolc:
undetectable		 5z84P-5oolc:
19.71
5z84W-5oolc:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ool 39S RIBOSOMAL
PROTEIN L44,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLN c 177
PHE c  92
LEU c  88
PHE c  83
 None
 1.05A 5z86C-5oolc:
undetectable
5z86J-5oolc:
undetectable		 5z86C-5oolc:
19.71
5z86J-5oolc:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ool 39S RIBOSOMAL
PROTEIN L44,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLN c 177
PHE c  92
LEU c  88
PHE c  83
 None
 1.04A 5z86P-5oolc:
undetectable
5z86W-5oolc:
undetectable		 5z86P-5oolc:
19.71
5z86W-5oolc:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ool 39S RIBOSOMAL
PROTEIN L44,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLN c 177
PHE c  92
LEU c  88
PHE c  83
 None
 1.01A 5zcoP-5oolc:
undetectable
5zcoW-5oolc:
undetectable		 5zcoP-5oolc:
19.71
5zcoW-5oolc:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ool 39S RIBOSOMAL
PROTEIN L44,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLN c 177
PHE c  92
LEU c  88
PHE c  83
 None
 1.02A 5zcpC-5oolc:
undetectable
5zcpJ-5oolc:
undetectable		 5zcpC-5oolc:
19.71
5zcpJ-5oolc:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ool 39S RIBOSOMAL
PROTEIN L44,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 GLN c 177
PHE c  92
LEU c  88
PHE c  83
 None
 1.04A 5zcpP-5oolc:
undetectable
5zcpW-5oolc:
undetectable		 5zcpP-5oolc:
19.71
5zcpW-5oolc:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 MET d  57
GLN d  58
ARG d  61
 None
 1.04A 6fn9A-5oold:
undetectable		 6fn9A-5oold:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 MET d  57
GLN d  58
ARG d  61
 None
 1.07A 6fnaB-5oold:
undetectable		 6fnaB-5oold:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5ool 39S RIBOSOMAL
PROTEIN L45,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 MET d  57
GLN d  58
ARG d  61
 None
 1.04A 6fnbA-5oold:
undetectable		 6fnbA-5oold:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 ASP 6 302
ARG 6 299
GLU 6 231
GLU 6 227
 None
 1.26A 6mn4C-5ool6:
undetectable		 6mn4C-5ool6:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5ool 39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ASP 6 302
ARG 6 299
GLU 6 231
GLU 6 227
 None
 1.01A 6mn5E-5ool6:
undetectable		 6mn5E-5ool6:
11.29