SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 PHE 7 230
VAL 7 263
TYR 7 181
ILE 7 154
PHE 7 260
 None
 1.39A 1fkfA-5oom7:
undetectable		 1fkfA-5oom7:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR X 148
ARG X 130
LEU X 134
TYR X 144
GLY X  82
 None
 1.08A 1httB-5oomX:
undetectable		 1httB-5oomX:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR X 148
ARG X 130
LEU X 134
TYR X 144
GLY X  82
 None
 1.17A 1httC-5oomX:
undetectable		 1httC-5oomX:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 THR X 148
ARG X 130
LEU X 134
TYR X 144
GLY X  82
 None
 1.12A 1httD-5oomX:
undetectable		 1httD-5oomX:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU 7 189
TRP 7 192
PHE 7 158
VAL 7 164
 None
 1.29A 1ibgH-5oom7:
undetectable		 1ibgH-5oom7:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TRP X   9
VAL X   8
PRO X   7
 None
 0.97A 1rg1A-5oomX:
undetectable		 1rg1A-5oomX:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 TRP X   9
VAL X   8
PRO X   7
 None
 0.96A 1rh0A-5oomX:
undetectable		 1rh0A-5oomX:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_C_CHDC3525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP 7 313
ASP 7 205
THR 7 203
TYR 7 278
 None
 1.49A 1v54A-5oom7:
undetectable
1v54C-5oom7:
undetectable		 1v54A-5oom7:
19.11
1v54C-5oom7:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4525_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE III)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP 7 313
ASP 7 205
THR 7 203
TYR 7 278
 None
 1.48A 1v54N-5oom7:
undetectable
1v54P-5oom7:
undetectable		 1v54N-5oom7:
19.11
1v54P-5oom7:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 5oom 39S RIBOSOMAL
PROTEIN L23,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L47,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		4 / 8 ASP Y  70
TRP Y  74
GLY Y  75
PHE U 111
 None
 0.88A 2aouA-5oomY:
undetectable		 2aouA-5oomY:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 5oom ACYL CARRIER
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 VAL w  83
VAL w 145
LEU w  84
ASP w 146
 None
 1.03A 2ddwA-5oomw:
undetectable		 2ddwA-5oomw:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_B_PXLB1005_1
(PYRIDOXINE KINASE)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 SER 7 201
LEU 7 199
THR 7 195
PRO 7 194
 None
 0.80A 2ddwB-5oom7:
undetectable		 2ddwB-5oom7:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP 7 313
ASP 7 205
THR 7 203
TYR 7 278
 None
 1.49A 2dyrA-5oom7:
undetectable
2dyrC-5oom7:
undetectable		 2dyrA-5oom7:
19.11
2dyrC-5oom7:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP 7 313
ASP 7 205
THR 7 203
TYR 7 278
 None
 1.48A 2dyrN-5oom7:
undetectable
2dyrP-5oom7:
undetectable		 2dyrN-5oom7:
19.11
2dyrP-5oom7:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP 7 313
ASP 7 205
THR 7 203
TYR 7 278
 None
 1.49A 2eijA-5oom7:
undetectable
2eijC-5oom7:
undetectable		 2eijA-5oom7:
19.11
2eijC-5oom7:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP 7 313
ASP 7 205
THR 7 203
TYR 7 278
 None
 1.47A 2eijN-5oom7:
undetectable
2eijP-5oom7:
undetectable		 2eijN-5oom7:
19.11
2eijP-5oom7:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP 7 313
ASP 7 205
THR 7 203
TYR 7 278
 None
 1.48A 2eikN-5oom7:
undetectable
2eikP-5oom7:
undetectable		 2eikN-5oom7:
19.11
2eikP-5oom7:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP 7 313
ASP 7 205
THR 7 203
TYR 7 278
 None
 1.48A 2eilN-5oom7:
undetectable
2eilP-5oom7:
undetectable		 2eilN-5oom7:
19.11
2eilP-5oom7:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 5oom 39S RIBOSOMAL
PROTEIN L43,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 ILE b  63
ARG b  74
ILE b  89
PHE b  46
 None
C  A2284 ( 3.3A)
None
None
 0.85A 2q6hA-5oomb:
undetectable		 2q6hA-5oomb:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 5oom 39S RIBOSOMAL
PROTEIN L23,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L47,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 LEU Y 106
ARG U  21
VAL U  19
ALA U   2
ASP Y 143
 None
 1.20A 2q72A-5oomY:
3.8		 2q72A-5oomY:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 LEU X 146
ASP X 142
ILE X 187
MET X 165
 None
 1.05A 2qqdA-5oomX:
undetectable
2qqdE-5oomX:
undetectable		 2qqdA-5oomX:
10.42
2qqdE-5oomX:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 5oom 39S RIBOSOMAL
PROTEIN L22,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER T 147
TYR T 174
HIS T 173
 None
None
C  A1672 ( 3.6A)
 0.55A 2r2vD-5oomT:
undetectable		 2r2vD-5oomT:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR X  39
PRO X  40
VAL X  41
ARG X 130
 None
 1.05A 2v41E-5oomX:
undetectable
2v41F-5oomX:
undetectable		 2v41E-5oomX:
20.88
2v41F-5oomX:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 THR X  39
PRO X  40
VAL X  41
ARG X 130
 None
 1.05A 2v41E-5oomX:
undetectable
2v41F-5oomX:
undetectable		 2v41E-5oomX:
20.88
2v41F-5oomX:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR X  39
PRO X  40
VAL X  41
ARG X 130
 None
 1.06A 2v41G-5oomX:
undetectable
2v41H-5oomX:
undetectable		 2v41G-5oomX:
20.88
2v41H-5oomX:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 5oom 39S RIBOSOMAL
PROTEIN L22,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 SER T  98
HIS T  75
ASP T 131
 None
 0.77A 2wa2B-5oomT:
undetectable		 2wa2B-5oomT:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5oom MITOCHONDRIAL
ASSEMBLY OF
RIBOSOMAL LARGE
SUBUNIT PROTEIN 1
MIEF1 UPSTREAM OPEN
READING FRAME
PROTEIN
(Homo
sapiens;
Homo
sapiens) 		4 / 7 GLN v  19
ILE u 112
TYR v  31
CYH u 110
 None
 1.41A 2xz5D-5oomv:
undetectable
2xz5E-5oomv:
undetectable		 2xz5D-5oomv:
15.00
2xz5E-5oomv:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_A_CHDA1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP 7 313
ASP 7 205
THR 7 203
TYR 7 278
 None
 1.49A 2y69A-5oom7:
undetectable
2y69C-5oom7:
undetectable		 2y69A-5oom7:
19.11
2y69C-5oom7:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 5oom 39S RIBOSOMAL
PROTEIN L22,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PRO T 183
ILE T 142
LEU T 178
ALA T 124
LEU T 103
 None
 1.15A 3a50A-5oomT:
undetectable		 3a50A-5oomT:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP 7 313
ASP 7 205
THR 7 203
TYR 7 278
 None
 1.49A 3ag3N-5oom7:
undetectable
3ag3P-5oom7:
undetectable		 3ag3N-5oom7:
19.11
3ag3P-5oom7:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 5oom 39S RIBOSOMAL
PROTEIN L27,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 GLY W  78
PRO W  77
ILE W  66
CYH W  88
PHE W  73
 None
None
A  A2861 ( 3.9A)
C  A2872 ( 3.0A)
None
 1.45A 3ko0H-5oomW:
1.6
3ko0I-5oomW:
2.0		 3ko0H-5oomW:
19.86
3ko0I-5oomW:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5oom 39S RIBOSOMAL
PROTEIN L23,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L47,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		5 / 12 PHE U 105
THR Y 114
PHE Y  68
LEU U  57
VAL U  65
 None
 1.07A 3u9fP-5oomU:
undetectable
3u9fS-5oomU:
undetectable		 3u9fP-5oomU:
20.35
3u9fS-5oomU:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 PHE 7 230
VAL 7 263
TYR 7 181
ILE 7 154
PHE 7 260
 None
 1.40A 3uqaA-5oom7:
6.3		 3uqaA-5oom7:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5oom 39S RIBOSOMAL
PROTEIN L22,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 VAL T 120
ALA T 124
LEU T  90
ILE T 116
LEU T 178
 None
 1.13A 3zosA-5oomT:
undetectable
3zosB-5oomT:
undetectable		 3zosA-5oomT:
19.94
3zosB-5oomT:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 PRO X  38
SER X  75
PHE X  71
ASP X 152
 None
 1.23A 4ndnA-5oomX:
undetectable		 4ndnA-5oomX:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 PRO X  38
SER X  75
PHE X  71
ASP X 152
 None
 1.32A 4ndnC-5oomX:
undetectable		 4ndnC-5oomX:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5oom 39S RIBOSOMAL
PROTEIN L30,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 PHE Z  46
ILE Z 119
ILE Z 117
ILE Z  41
VAL Z 113
 None
 0.93A 4nkxA-5oomZ:
undetectable		 4nkxA-5oomZ:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5oom ACYL CARRIER
PROTEIN,
MITOCHONDRIAL
MIEF1 UPSTREAM OPEN
READING FRAME
PROTEIN
(Homo
sapiens) 		5 / 10 ILE v  35
LEU w 110
GLN w 115
LEU v  10
PHE v  39
 None
 1.22A 4r3aB-5oomv:
undetectable		 4r3aB-5oomv:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5oom 39S RIBOSOMAL
PROTEIN L43,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE b  54
PRO b  59
VAL b  61
ALA b  55
 None
 1.30A 4w5oA-5oomb:
undetectable		 4w5oA-5oomb:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5oom 39S RIBOSOMAL
PROTEIN L43,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE b  54
PRO b  59
VAL b  61
ALA b  55
 None
 1.30A 4z4cA-5oomb:
undetectable		 4z4cA-5oomb:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5oom 39S RIBOSOMAL
PROTEIN L43,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE b  54
PRO b  59
VAL b  61
ALA b  55
 None
 1.31A 4z4dA-5oomb:
undetectable		 4z4dA-5oomb:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5oom 39S RIBOSOMAL
PROTEIN L43,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 PHE b  54
PRO b  59
VAL b  61
ALA b  55
 None
 1.29A 4z4eA-5oomb:
undetectable		 4z4eA-5oomb:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 5oom MIEF1 UPSTREAM OPEN
READING FRAME
PROTEIN
ACYL CARRIER
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		4 / 4 ILE w  93
ARG v  36
TYR w  90
GLU w 117
 None
 1.30A 4zzbD-5oomw:
undetectable		 4zzbD-5oomw:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5oom MIEF1 UPSTREAM OPEN
READING FRAME
PROTEIN
ACYL CARRIER
PROTEIN,
MITOCHONDRIAL
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG v  36
TYR w  90
GLU w 117
 None
 0.62A 4zzbE-5oomv:
undetectable		 4zzbE-5oomv:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 5oom MIEF1 UPSTREAM OPEN
READING FRAME
PROTEIN
(Homo
sapiens) 		4 / 6 ILE v  69
PHE v  61
ILE v  35
GLU v  38
 None
 1.46A 4zzcB-5oomv:
undetectable
4zzcC-5oomv:
undetectable		 4zzcB-5oomv:
14.06
4zzcC-5oomv:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 5oom 39S RIBOSOMAL
PROTEIN L43,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 4 VAL b  47
ILE b  63
ASN b  66
VAL b  75
 None
 1.32A 5ajqA-5oomb:
undetectable		 5ajqA-5oomb:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP 7 313
ASP 7 205
THR 7 203
TYR 7 278
 None
 1.50A 5b1aN-5oom7:
undetectable
5b1aP-5oom7:
undetectable		 5b1aN-5oom7:
19.11
5b1aP-5oom7:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 TRP 7 313
ASP 7 205
THR 7 203
TYR 7 278
 None
 1.50A 5b3sN-5oom7:
undetectable
5b3sP-5oom7:
undetectable		 5b3sN-5oom7:
19.11
5b3sP-5oom7:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 SER X 116
ASP X 173
ARG X 171
GLU X 198
 None
 1.06A 5btfA-5oomX:
undetectable
5btfC-5oomX:
undetectable
5btfD-5oomX:
undetectable		 5btfA-5oomX:
19.68
5btfC-5oomX:
19.68
5btfD-5oomX:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 5oom 39S RIBOSOMAL
PROTEIN L39,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 ILE 7 125
PRO 7  88
VAL 7 138
ILE 7 104
TYR 7  99
 None
 1.24A 5iepA-5oom7:
1.5		 5iepA-5oom7:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 5oom 39S RIBOSOMAL
PROTEIN L47,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 PRO Y 129
ARG Y 131
GLU Y 130
 None
 0.99A 5j6hA-5oomY:
undetectable		 5j6hA-5oomY:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5oom 39S RIBOSOMAL
PROTEIN L27,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 VAL W  61
HIS W 132
VAL W  81
 None
 0.70A 5jmnC-5oomW:
2.3		 5jmnC-5oomW:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5oom 39S RIBOSOMAL
PROTEIN L22,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE T  73
ILE T 117
VAL T 120
LEU T 121
ILE T 142
 None
 1.03A 5mugA-5oomT:
undetectable		 5mugA-5oomT:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 5oom MITOCHONDRIAL
ASSEMBLY OF
RIBOSOMAL LARGE
SUBUNIT PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE u 172
LEU u 101
LEU u 100
LEU u 179
VAL u 125
 None
 1.11A 5uanB-5oomu:
undetectable		 5uanB-5oomu:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5oom 39S RIBOSOMAL
PROTEIN L28,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR X 128
THR X 131
TYR X 144
PRO X  72
 None
 1.35A 5x2sI-5oomX:
undetectable
5x2sJ-5oomX:
undetectable
5x2sK-5oomX:
undetectable		 5x2sI-5oomX:
19.92
5x2sJ-5oomX:
19.52
5x2sK-5oomX:
19.92