SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oon'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EUP_A_ASDA452_1
(CYTOCHROME P450ERYF)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		4 / 8 PHE A 195
ILE A  95
LEU A  90
LEU A  68
 None
 0.90A 1eupA-5oonA:
undetectable		 1eupA-5oonA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 GLY A 176
ALA A 177
SER A 180
GLY A 182
LEU A 184
 None
 0.90A 1fe2A-5oonA:
undetectable		 1fe2A-5oonA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 GLY A 176
ALA A 177
SER A 180
GLY A 182
LEU A 184
 None
 1.03A 1igxA-5oonA:
undetectable		 1igxA-5oonA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 VAL A 201
LEU A  71
LEU A  68
PHE A  64
GLU A  83
 None
 1.36A 1kw0A-5oonA:
undetectable		 1kw0A-5oonA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		4 / 6 LEU A 198
PHE A 197
ALA A 200
LEU A  68
 None
 0.99A 1ukbA-5oonA:
undetectable		 1ukbA-5oonA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		4 / 7 ALA A 209
THR A 208
ALA A 207
ARG A 174
 None
 0.93A 2ql8A-5oonA:
undetectable
2ql8B-5oonA:
undetectable		 2ql8A-5oonA:
undetectable
2ql8B-5oonA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 ILE A  12
VAL A  15
ILE A  52
ILE A 232
LEU A   7
 None
 1.24A 3fpjB-5oonA:
undetectable		 3fpjB-5oonA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 9 ALA A 228
ILE A 232
PHE A 235
THR A  44
PHE A  48
 None
 1.33A 3qelD-5oonA:
undetectable		 3qelD-5oonA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 GLY A 176
ALA A 177
SER A 180
GLY A 182
LEU A 184
 None
 0.89A 4e1gA-5oonA:
undetectable		 4e1gA-5oonA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 GLY A 176
ALA A 177
SER A 180
GLY A 182
LEU A 184
 None
 0.94A 4e1gB-5oonA:
undetectable		 4e1gB-5oonA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 ILE A 179
ARG A 261
ALA A 167
SER A 173
MET A 152
 None
 1.01A 4lnwA-5oonA:
undetectable		 4lnwA-5oonA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 ILE A 179
ARG A 261
ALA A 167
SER A 173
MET A 152
 None
 0.98A 4lnxA-5oonA:
undetectable		 4lnxA-5oonA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 LEU A  71
LEU A 198
PHE A 195
LEU A  90
THR A  91
 None
 1.09A 5hnwB-5oonA:
undetectable		 5hnwB-5oonA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 LEU A  71
LEU A 198
PHE A 195
LEU A  90
THR A  91
 None
 1.14A 5hnyB-5oonA:
undetectable		 5hnyB-5oonA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		3 / 3 SER A 193
SER A 196
PHE A 254
 None
 0.91A 5mugA-5oonA:
undetectable		 5mugA-5oonA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.45A 5uh6C-5oonA:
undetectable		 5uh6C-5oonA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.45A 5uhbC-5oonA:
1.1		 5uhbC-5oonA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.42A 5uhcC-5oonA:
undetectable		 5uhcC-5oonA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.47A 5uhdC-5oonA:
undetectable		 5uhdC-5oonA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		5 / 12 LEU A 246
SER A 193
ILE A 179
ARG A 261
HIS A  30
 None
None
None
None
OLC  A 304 (-4.5A)
 1.45A 5uhgC-5oonA:
undetectable		 5uhgC-5oonA:
5.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5oon UNDECAPRENYL-DIPHOSP
HATASE
(Escherichia
coli) 		4 / 5 PHE A  22
PRO A 202
MET A 204
VAL A  60
 None
 1.25A 6ekzA-5oonA:
undetectable		 6ekzA-5oonA:
22.47