SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5opf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		5 / 12 GLY A 145
ALA A 146
ASP A 147
THR A 210
ILE A 149
 None
 0.90A 1fb7A-5opfA:
undetectable		 1fb7A-5opfA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		5 / 12 VAL A 191
GLY A  38
TYR A  48
GLN A 112
HIS A  37
 None
None
None
None
CU  A 301 (-3.0A)
 1.38A 1h1dA-5opfA:
undetectable		 1h1dA-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		5 / 11 GLY A 145
ALA A 146
ASP A 147
THR A 210
ILE A 149
 None
 0.87A 1ohrA-5opfA:
undetectable		 1ohrA-5opfA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		3 / 3 GLN A 213
HIS A  96
ARG A  89
 None
 1.06A 1zlqA-5opfA:
undetectable		 1zlqA-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		4 / 5 VAL A 208
VAL A 153
THR A 127
THR A 210
 None
 1.27A 3bjwG-5opfA:
undetectable		 3bjwG-5opfA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		4 / 5 VAL A 208
VAL A 153
THR A 127
THR A 210
 None
 1.21A 3bjwD-5opfA:
undetectable		 3bjwD-5opfA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		5 / 11 GLY A 145
ALA A 146
ASP A 147
THR A 210
ILE A 149
 None
 0.90A 3ekxA-5opfA:
undetectable		 3ekxA-5opfA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		5 / 12 GLY A 145
ALA A 146
ASP A 147
THR A 210
ILE A 149
 None
 0.88A 3tkgC-5opfA:
undetectable		 3tkgC-5opfA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		4 / 8 TRP A 212
HIS A 144
PHE A 138
TRP A  84
 None
CU  A 301 (-3.2A)
None
None
 1.49A 3v35A-5opfA:
undetectable		 3v35A-5opfA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		5 / 5 HIS A  37
ALA A 142
HIS A 144
GLN A 219
TYR A 221
 CU  A 301 (-3.0A)
CU  A 301 ( 3.9A)
CU  A 301 (-3.2A)
CU  A 301 ( 4.2A)
None
 0.25A 4gboA-5opfA:
34.4		 4gboA-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		4 / 5 HIS A  37
HIS A 216
GLN A 219
TYR A 221
 CU  A 301 (-3.0A)
None
CU  A 301 ( 4.2A)
None
 1.13A 4gboA-5opfA:
34.4		 4gboA-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		5 / 5 HIS A  37
ALA A 142
HIS A 144
GLN A 219
TYR A 221
 CU  A 301 (-3.0A)
CU  A 301 ( 3.9A)
CU  A 301 (-3.2A)
CU  A 301 ( 4.2A)
None
 0.56A 4gboB-5opfA:
34.0		 4gboB-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_B_CUB301_0
(E7)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		4 / 5 HIS A  37
HIS A 216
GLN A 219
TYR A 221
 CU  A 301 (-3.0A)
None
CU  A 301 ( 4.2A)
None
 0.78A 4gboB-5opfA:
34.0		 4gboB-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		5 / 5 HIS A  37
ALA A 142
HIS A 144
GLN A 219
TYR A 221
 CU  A 301 (-3.0A)
CU  A 301 ( 3.9A)
CU  A 301 (-3.2A)
CU  A 301 ( 4.2A)
None
 0.24A 5uizA-5opfA:
34.4		 5uizA-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_B_CUB301_0
(AA10A)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		4 / 4 HIS A  37
HIS A 144
GLN A 219
TYR A 221
 CU  A 301 (-3.0A)
CU  A 301 (-3.2A)
CU  A 301 ( 4.2A)
None
 0.61A 5uizB-5opfA:
34.0		 5uizB-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_B_CUB301_0
(AA10A)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		4 / 4 HIS A  37
HIS A 216
GLN A 219
TYR A 221
 CU  A 301 (-3.0A)
None
CU  A 301 ( 4.2A)
None
 0.80A 5uizB-5opfA:
34.0		 5uizB-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		4 / 6 SER A 163
TYR A 158
ASP A 102
THR A 154
 None
 1.47A 6djzA-5opfA:
undetectable		 6djzA-5opfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_D_ACTD404_0
(L-LYSINE
3-HYDROXYLASE)		 5opf CHITIN-BINDING
DOMAIN 3 PROTEIN
(Micromonospora
aurantiaca) 		4 / 6 GLU A  90
HIS A 216
ALA A 214
GLN A 213
 None
 1.22A 6f6jC-5opfA:
undetectable
6f6jD-5opfA:
undetectable		 6f6jC-5opfA:
undetectable
6f6jD-5opfA:
undetectable