SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5opt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5opt 40S RIBOSOMAL
PROTEIN S4
(Trypanosoma
cruzi) 		4 / 5 THR L 181
GLU L 124
THR L 138
HIS L  33
 None
 1.31A 1d4fB-5optL:
undetectable		 1d4fB-5optL:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3001_1
(SERUM ALBUMIN)		 5opt 40S RIBOSOMAL
PROTEIN S16,
PUTATIVE
40S RIBOSOMAL
PROTEIN S5, PUTATIVE
(Trypanosoma
cruzi) 		5 / 11 LYS r  19
LEU O  73
LEU r  50
ARG r  88
ALA O  39
 C  E2143 ( 3.1A)
A  E2059 ( 4.5A)
None
None
None
 1.06A 1hk3A-5optr:
1.4		 1hk3A-5optr:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5opt 40S RIBOSOMAL
PROTEIN S5, PUTATIVE
RIBOSOMAL PROTEIN
S25, PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 LEU O 155
ILE a  70
THR a  67
THR O  82
ILE O  85
 U  E1990 ( 3.5A)
None
None
None
None
 1.31A 1i18A-5optO:
undetectable
1i18B-5optO:
undetectable		 1i18A-5optO:
20.62
1i18B-5optO:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5opt 40S RIBOSOMAL
PROTEIN S5, PUTATIVE
RIBOSOMAL PROTEIN
S25, PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 THR O  82
ILE O  85
LEU O 155
ILE a  70
THR a  67
 None
None
U  E1990 ( 3.5A)
None
None
 1.33A 1i18A-5optO:
undetectable
1i18B-5optO:
undetectable		 1i18A-5optO:
20.62
1i18B-5optO:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 5opt 40S RIBOSOMAL
PROTEIN S4
(Trypanosoma
cruzi) 		3 / 3 ASP L 140
LEU L 120
LEU L 121
 None
 0.76A 1ikeA-5optL:
undetectable		 1ikeA-5optL:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5opt 40S RIBOSOMAL
PROTEIN S26
40S RIBOSOMAL
PROTEIN S3A-2
(Trypanosoma
cruzi;
Trypanosoma
cruzi) 		5 / 12 TYR T  62
GLY T  65
ALA T  56
SER T  59
TYR W  83
 None
 1.26A 1kiaD-5optT:
undetectable		 1kiaD-5optT:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5opt 40S RIBOSOMAL
PROTEIN S17,
PUTATIVE
40S RIBOSOMAL
PROTEIN SA
(Trypanosoma
cruzi) 		5 / 12 VAL f  22
LEU k 164
SER k 162
PHE k 161
HIS k 155
 None
 1.29A 1mmkA-5optf:
undetectable		 1mmkA-5optf:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5opt 40S RIBOSOMAL
PROTEIN S26
40S RIBOSOMAL
PROTEIN S3A-2
(Trypanosoma
cruzi;
Trypanosoma
cruzi) 		5 / 12 TYR T  62
GLY T  65
ALA T  56
SER T  59
TYR W  83
 None
 1.26A 1nbhA-5optT:
undetectable		 1nbhA-5optT:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5opt 40S RIBOSOMAL
PROTEIN S26
40S RIBOSOMAL
PROTEIN S3A-2
(Trypanosoma
cruzi;
Trypanosoma
cruzi) 		5 / 12 TYR T  62
GLY T  65
ALA T  56
SER T  59
TYR W  83
 None
 1.25A 1nbhC-5optT:
undetectable		 1nbhC-5optT:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5opt 40S RIBOSOMAL
PROTEIN S26
40S RIBOSOMAL
PROTEIN S3A-2
(Trypanosoma
cruzi;
Trypanosoma
cruzi) 		5 / 12 TYR T  62
GLY T  65
ALA T  56
SER T  59
TYR W  83
 None
 1.25A 1nbhD-5optT:
undetectable		 1nbhD-5optT:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 5opt 40S RIBOSOMAL
PROTEIN S4
(Trypanosoma
cruzi) 		3 / 3 ASP L 140
LEU L 120
LEU L 121
 None
 0.79A 1np1B-5optL:
undetectable		 1np1B-5optL:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 5opt RIBOSOMAL PROTEIN
S7, PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 PHE Q  67
LEU Q 134
VAL Q 177
THR Q 182
 A  E 764 ( 4.5A)
None
None
None
 1.11A 1o76B-5optQ:
undetectable		 1o76B-5optQ:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 5opt RIBOSOMAL PROTEIN
S25, PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 LYS a  84
LEU a  81
ALA a  83
SER a  72
 A  E2065 ( 3.4A)
None
None
None
 0.95A 1tt6B-5opta:
undetectable		 1tt6B-5opta:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 5opt RIBOSOMAL PROTEIN
S7, PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 PHE Q  67
LEU Q 134
VAL Q 177
THR Q 182
 A  E 764 ( 4.5A)
None
None
None
 1.18A 1uyuB-5optQ:
undetectable		 1uyuB-5optQ:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 5opt 40S RIBOSOMAL
PROTEIN S16,
PUTATIVE
40S RIBOSOMAL
PROTEIN S5, PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 ARG r  64
ILE r  91
ALA r  57
ALA O   3
 None
 0.79A 1w0gA-5optr:
undetectable		 1w0gA-5optr:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5opt 40S RIBOSOMAL
PROTEIN S5, PUTATIVE
(Trypanosoma
cruzi) 		5 / 11 THR O  33
VAL O  55
THR O  59
VAL O  76
VAL O  79
 None
 1.24A 2a1nA-5optO:
undetectable		 2a1nA-5optO:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5opt 40S RIBOSOMAL
PROTEIN S21,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 ILE g  41
ALA g  40
GLN g  38
PHE g  57
ILE g  83
 None
 1.13A 2aclC-5optg:
undetectable		 2aclC-5optg:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5opt 40S RIBOSOMAL
PROTEIN S10,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 PHE n  18
PHE n  17
ASN n  96
ILE n  23
ILE n  62
 None
 1.24A 2bjfA-5optn:
undetectable		 2bjfA-5optn:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 ASP p  72
ILE p  24
ASN p  77
PHE p 117
 None
 1.21A 2jc9A-5optp:
undetectable		 2jc9A-5optp:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5opt RIBOSOMAL PROTEIN
S7, PUTATIVE
(Trypanosoma
cruzi) 		4 / 4 LEU Q  54
THR Q  53
ILE Q 173
HIS Q 176
 None
A  E 765 ( 4.9A)
None
None
 1.10A 2jfaB-5optQ:
undetectable		 2jfaB-5optQ:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 TRP p 312
ARG p 261
ALA p 275
LEU p 274
 None
 0.89A 2o01A-5optp:
undetectable		 2o01A-5optp:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 5opt 40S RIBOSOMAL
PROTEIN S2, PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 ALA d 220
THR d 221
ALA d 224
PRO d 191
 None
 0.80A 2ql8A-5optd:
undetectable
2ql8B-5optd:
undetectable		 2ql8A-5optd:
21.48
2ql8B-5optd:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5opt 40S RIBOSOMAL
PROTEIN S12
(Trypanosoma
cruzi) 		4 / 7 LEU i  61
LEU i  34
ILE i  32
GLU i 134
 None
 0.95A 2qqdA-5opti:
undetectable
2qqdE-5opti:
undetectable		 2qqdA-5opti:
16.90
2qqdE-5opti:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 5opt 40S RIBOSOMAL
PROTEIN S12
UBIQUITIN/RIBOSOMAL
PROTEIN S27A,
PUTATIVE
(Trypanosoma
cruzi;
Trypanosoma
cruzi) 		3 / 3 LYS j 142
ARG i  52
VAL j 129
 U  E1721 ( 3.5A)
C  E1722 ( 2.9A)
U  E1721 ( 3.7A)
 1.08A 2r2vC-5optj:
undetectable
2r2vD-5optj:
undetectable		 2r2vC-5optj:
17.39
2r2vD-5optj:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 SER p  45
VAL p 311
TYR p 301
ASP p  48
 None
 1.48A 2x45A-5optp:
undetectable		 2x45A-5optp:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 5opt 40S RIBOSOMAL
PROTEIN SA
(Trypanosoma
cruzi) 		4 / 6 GLY f  29
SER f 173
ILE f  51
ILE f  41
 None
 0.99A 3a7eA-5optf:
undetectable		 3a7eA-5optf:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 5opt 40S RIBOSOMAL
PROTEIN S2, PUTATIVE
40S RIBOSOMAL
PROTEIN S21,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 VAL d 144
ILE d 161
PRO d 178
ILE d 146
THR g  30
 None
 1.11A 3clbD-5optd:
undetectable		 3clbD-5optd:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 THR p  27
SER p  76
LEU p  75
THR p  25
 None
 0.85A 3deuB-5optp:
undetectable		 3deuB-5optp:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5opt 40S RIBOSOMAL
PROTEIN S2, PUTATIVE
40S RIBOSOMAL
PROTEIN S21,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 10 VAL d 144
ILE d 161
PRO d 178
ILE d 146
THR g  30
 None
 1.15A 3hbbD-5optd:
undetectable		 3hbbD-5optd:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_A_AZMA263_1
(CARBONIC ANHYDRASE 9)		 5opt 40S RIBOSOMAL
PROTEIN S4
(Trypanosoma
cruzi) 		5 / 11 HIS L 139
GLU L  37
HIS L  33
VAL L 234
THR L 181
 None
 1.34A 3iaiA-5optL:
undetectable		 3iaiA-5optL:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_B_AZMB263_1
(CARBONIC ANHYDRASE 9)		 5opt 40S RIBOSOMAL
PROTEIN S4
(Trypanosoma
cruzi) 		5 / 11 HIS L 139
GLU L  37
HIS L  33
VAL L 234
THR L 181
 None
 1.34A 3iaiB-5optL:
undetectable		 3iaiB-5optL:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5opt 40S RIBOSOMAL
PROTEIN S6
(Trypanosoma
cruzi) 		3 / 3 ALA P 186
ARG P 190
LYS P 194
 None
C  E 318 ( 3.1A)
A  E 315 ( 3.0A)
 0.76A 3kp3B-5optP:
undetectable		 3kp3B-5optP:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5opt 40S RIBOSOMAL
PROTEIN S6
(Trypanosoma
cruzi) 		3 / 3 ALA P 186
ARG P 190
LYS P 194
 None
C  E 318 ( 3.1A)
A  E 315 ( 3.0A)
 0.49A 3kp5B-5optP:
undetectable		 3kp5B-5optP:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 LEU p 265
LEU p 210
SER p 213
ASP p 224
 None
 1.05A 3lm8A-5optp:
undetectable
3lm8C-5optp:
undetectable		 3lm8A-5optp:
22.16
3lm8C-5optp:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 ASP p 224
LEU p 265
LEU p 210
SER p 213
 None
 0.92A 3lm8A-5optp:
undetectable
3lm8C-5optp:
undetectable		 3lm8A-5optp:
22.16
3lm8C-5optp:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5opt RIBOSOMAL PROTEIN
S7, PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 ARG Q  81
ASP Q 139
ASP Q 163
ASP Q 160
 None
 1.49A 3naiA-5optQ:
undetectable		 3naiA-5optQ:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 5opt RIBOSOMAL PROTEIN
S25, PUTATIVE
40S RIBOSOMAL
PROTEIN S18,
PUTATIVE
(Trypanosoma
cruzi;
Trypanosoma
cruzi) 		3 / 3 ALA a  45
VAL a  46
GLN u  11
 None
 0.71A 3of4B-5opta:
undetectable		 3of4B-5opta:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 5opt 40S RIBOSOMAL
PROTEIN S18,
PUTATIVE
RIBOSOMAL PROTEIN
S25, PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 ARG u  25
LEU a  81
THR a  52
 C  E2067 ( 4.2A)
None
None
 0.89A 3oxcA-5optu:
undetectable		 3oxcA-5optu:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P73_A_ACTA275_0
(MHC RFP-Y CLASS I
ALPHA CHAIN)		 5opt 40S RIBOSOMAL
PROTEIN SA
(Trypanosoma
cruzi) 		3 / 3 ILE f  68
VAL f 185
ARG f 189
 None
 0.72A 3p73A-5optf:
undetectable		 3p73A-5optf:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 5opt RIBOSOMAL PROTEIN
S19, PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 LEU o 116
ARG o  73
ILE o 108
ARG o 111
 None
U  E2028 ( 3.0A)
None
A  E2031 ( 3.4A)
 1.43A 3ticA-5opto:
undetectable		 3ticA-5opto:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 5opt 40S RIBOSOMAL
PROTEIN S11,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 VAL X 100
HIS X  91
SER X 121
THR X 123
 C  E 396 ( 4.9A)
None
G  E 397 ( 3.4A)
None
 0.96A 3tj7A-5optX:
undetectable
3tj7B-5optX:
undetectable		 3tj7A-5optX:
16.75
3tj7B-5optX:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 5opt 40S RIBOSOMAL
PROTEIN S23,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 LYS M 121
VAL M 123
HIS M  46
 U  E 652 ( 3.3A)
None
A  E 653 ( 4.4A)
 1.04A 3tj7A-5optM:
undetectable		 3tj7A-5optM:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 5opt 40S RIBOSOMAL
PROTEIN S11,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 VAL X 100
HIS X  91
SER X 121
THR X 123
 C  E 396 ( 4.9A)
None
G  E 397 ( 3.4A)
None
 0.91A 3tj7C-5optX:
undetectable
3tj7D-5optX:
undetectable		 3tj7C-5optX:
16.75
3tj7D-5optX:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 5opt 40S RIBOSOMAL
PROTEIN S11,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 VAL X 100
HIS X  91
SER X 121
THR X 123
 C  E 396 ( 4.9A)
None
G  E 397 ( 3.4A)
None
 0.94A 3tj7C-5optX:
undetectable
3tj7D-5optX:
undetectable		 3tj7C-5optX:
16.75
3tj7D-5optX:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5opt RIBOSOMAL PROTEIN
S7, PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 PRO Q  44
VAL Q  76
LEU Q  98
ASN Q  49
 None
 0.94A 3u5kB-5optQ:
undetectable		 3u5kB-5optQ:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5opt 40S RIBOSOMAL
PROTEIN S2, PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 PHE d 217
SER d 207
LEU d 195
VAL d 203
ALA d 224
 None
C  E   4 ( 3.4A)
None
None
None
 1.38A 3u9fD-5optd:
undetectable
3u9fE-5optd:
undetectable		 3u9fD-5optd:
20.33
3u9fE-5optd:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5opt 40S RIBOSOMAL
PROTEIN SA
(Trypanosoma
cruzi) 		5 / 10 VAL f 127
ASP f 133
THR f  99
ILE f  90
TYR f 178
 None
 1.38A 3um5A-5optf:
undetectable		 3um5A-5optf:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 5opt 40S RIBOSOMAL
PROTEIN SA
(Trypanosoma
cruzi) 		5 / 12 LEU f 126
ALA f 149
ALA f 140
ALA f 136
ILE f 145
 None
 1.15A 3ut5D-5optf:
3.7		 3ut5D-5optf:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_SALA1505_1
(FERROCHELATASE,
MITOCHONDRIAL)		 5opt 40S RIBOSOMAL
PROTEIN S2, PUTATIVE
(Trypanosoma
cruzi) 		5 / 9 VAL d 203
SER d 207
LEU d 176
PRO d 191
LEU d 195
 None
C  E   4 ( 3.4A)
None
None
None
 1.49A 3w1wA-5optd:
undetectable
3w1wB-5optd:
undetectable		 3w1wA-5optd:
22.77
3w1wB-5optd:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 5opt 40S RIBOSOMAL
PROTEIN S4
(Trypanosoma
cruzi) 		4 / 5 ASP L 140
GLU L  37
GLY L  82
ASP L  70
 None
 1.12A 3w9tD-5optL:
undetectable		 3w9tD-5optL:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 ASP p 217
LYS p 216
ASP p 215
 None
 0.74A 4a7tA-5optp:
undetectable		 4a7tA-5optp:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5opt 40S RIBOSOMAL
PROTEIN S6
(Trypanosoma
cruzi) 		5 / 12 PHE P  16
PHE P  42
LEU P 105
ILE P 109
GLN P  54
 None
None
None
None
A  E 168 ( 4.1A)
 1.36A 4a83A-5optP:
undetectable		 4a83A-5optP:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 5opt RIBOSOMAL PROTEIN
S7, PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 VAL Q  76
LEU Q  83
LEU Q  98
ASN Q  49
 None
 0.77A 4a9jA-5optQ:
undetectable		 4a9jA-5optQ:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_B_TYLB1187_1
(BROMODOMAIN
CONTAINING 2)		 5opt RIBOSOMAL PROTEIN
S7, PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 VAL Q  76
LEU Q  83
LEU Q  98
ASN Q  49
 None
 0.71A 4a9jB-5optQ:
undetectable		 4a9jB-5optQ:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 5opt RIBOSOMAL PROTEIN
S7, PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 VAL Q  76
LEU Q  83
LEU Q  98
ASN Q  49
 None
 0.77A 4a9jC-5optQ:
undetectable		 4a9jC-5optQ:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5opt 40S RIBOSOMAL
PROTEIN S5, PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 VAL O  55
CYH O 141
VAL O  98
ILE O 137
 None
 1.08A 4aftD-5optO:
undetectable
4aftE-5optO:
undetectable		 4aftD-5optO:
21.72
4aftE-5optO:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5opt RIBOSOMAL PROTEIN
S25, PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 LYS a  84
LEU a  81
ALA a  83
SER a  72
 A  E2065 ( 3.4A)
None
None
None
 0.92A 4d7bB-5opta:
undetectable		 4d7bB-5opta:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5opt 40S RIBOSOMAL
PROTEIN S33,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 ASN U  88
ALA U 108
VAL U  70
ARG U  69
 None
 0.96A 4ijiH-5optU:
undetectable		 4ijiH-5optU:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 ASP p  88
SER p  84
HIS p  66
SER p  86
 None
 1.27A 4k7gB-5optp:
undetectable		 4k7gB-5optp:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 5opt RIBOSOMAL PROTEIN
S7, PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 ARG Q  77
ARG Q  81
ASP Q 160
ARG Q 166
 None
 1.35A 4kr4C-5optQ:
undetectable		 4kr4C-5optQ:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5opt 40S RIBOSOMAL
PROTEIN S3A-2
(Trypanosoma
cruzi) 		4 / 7 GLN W 101
LEU W 137
THR W 131
MET W 107
 None
 1.14A 4mbsA-5optW:
undetectable		 4mbsA-5optW:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 TYR p 250
THR p 166
LEU p 168
THR p 203
 None
 1.48A 4mbsB-5optp:
undetectable		 4mbsB-5optp:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5opt 40S RIBOSOMAL
PROTEIN S4
40S RIBOSOMAL
PROTEIN S6
(Trypanosoma
cruzi) 		4 / 5 TYR P 212
THR L 151
PRO L 147
VAL L 123
 None
 1.44A 4mjqA-5optP:
undetectable		 4mjqA-5optP:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 5opt RIBOSOMAL PROTEIN
S19, PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 ASP o  68
TYR o  71
TRP o  29
 G  E1997 ( 4.3A)
None
None
 1.43A 4p7nA-5opto:
undetectable		 4p7nA-5opto:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 12 LEU p  91
CYH p 101
GLU p  60
ALA p  42
ALA p  82
 None
 1.21A 4pclA-5optp:
undetectable		 4pclA-5optp:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5opt RIBOSOMAL PROTEIN
S25, PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 LYS a  84
LEU a  81
ALA a  83
SER a  72
 A  E2065 ( 3.4A)
None
None
None
 0.93A 4pwjB-5opta:
undetectable		 4pwjB-5opta:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 5opt 40S RIBOSOMAL
PROTEIN S3A-2
(Trypanosoma
cruzi) 		4 / 4 ASN W  37
LEU W 230
PHE W 102
TYR W 135
 None
 1.45A 4u14A-5optW:
undetectable		 4u14A-5optW:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WAN_C_ACTC303_0
(BRANCHPOINT-BRIDGING
PROTEIN)		 5opt 40S RIBOSOMAL
PROTEIN S5, PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 ASP O  26
ARG O 132
PRO O 129
 None
 1.08A 4wanC-5optO:
undetectable		 4wanC-5optO:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 5opt 40S RIBOSOMAL
PROTEIN S23,
PUTATIVE
(Trypanosoma
cruzi) 		5 / 9 SER M 103
ALA M  83
PHE M 120
LEU M 101
VAL M 100
 A  E 653 ( 4.5A)
None
None
None
None
 1.17A 4z69A-5optM:
undetectable		 4z69A-5optM:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5opt 40S RIBOSOMAL
PROTEIN S12
(Trypanosoma
cruzi) 		4 / 7 ILE i  77
LEU i  64
ARG i  57
LEU i 140
 None
 1.01A 5b1bA-5opti:
undetectable
5b1bJ-5opti:
undetectable		 5b1bA-5opti:
13.81
5b1bJ-5opti:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5opt RIBOSOMAL PROTEIN
S25, PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 LYS a  84
LEU a  81
ALA a  83
SER a  72
 A  E2065 ( 3.4A)
None
None
None
 0.88A 5bojB-5opta:
undetectable		 5bojB-5opta:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 ASP p  88
TRP p  87
VAL p 112
ALA p  85
 None
 1.34A 5dl9A-5optp:
undetectable		 5dl9A-5optp:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 SER p  86
ALA p  85
HIS p  66
LEU p  40
 None
 1.44A 5dzkb-5optp:
undetectable
5dzkp-5optp:
undetectable		 5dzkb-5optp:
19.51
5dzkp-5optp:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 SER p  86
ALA p  85
HIS p  66
LEU p  40
 None
 1.42A 5dzkc-5optp:
undetectable
5dzkq-5optp:
undetectable		 5dzkc-5optp:
19.51
5dzkq-5optp:
1.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5opt 40S RIBOSOMAL
PROTEIN S11,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 5 ARG X  87
ILE X  85
GLY X  56
ILE X 139
 None
 0.73A 5dzki-5optX:
undetectable
5dzkj-5optX:
undetectable
5dzkx-5optX:
undetectable		 5dzki-5optX:
20.59
5dzkj-5optX:
20.59
5dzkx-5optX:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 4 THR p 145
LEU p 133
HIS p 151
GLY p 127
 None
 1.34A 5gwyA-5optp:
undetectable		 5gwyA-5optp:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5opt 40S RIBOSOMAL
PROTEIN S2, PUTATIVE
40S RIBOSOMAL
PROTEIN S21,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 LYS d 154
ASP g  15
GLY g   5
ASP d 235
 None
 1.34A 5hp1A-5optd:
undetectable		 5hp1A-5optd:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5opt 40S RIBOSOMAL
PROTEIN S2, PUTATIVE
40S RIBOSOMAL
PROTEIN S21,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 LYS d 154
GLY g   5
ASP d 235
ASP g  15
 None
 1.12A 5hp1A-5optd:
undetectable		 5hp1A-5optd:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5opt 40S RIBOSOMAL
PROTEIN S33,
PUTATIVE
40S RIBOSOMAL
PROTEIN S5, PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 VAL U  49
SER O  25
MET O 130
 None
None
A  E2148 ( 4.7A)
 0.86A 5ikqA-5optU:
undetectable		 5ikqA-5optU:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5opt 40S RIBOSOMAL
PROTEIN S3A-2
(Trypanosoma
cruzi) 		3 / 3 VAL W 187
HIS W 103
VAL W 219
 None
C  E1256 ( 4.5A)
None
 0.66A 5jmnC-5optW:
undetectable		 5jmnC-5optW:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5opt 40S RIBOSOMAL
PROTEIN S3A-2
(Trypanosoma
cruzi) 		3 / 3 ARG W  41
PRO W 238
ASN W  97
 None
 0.99A 5jwaA-5optW:
undetectable
5jwaH-5optW:
undetectable		 5jwaA-5optW:
19.48
5jwaH-5optW:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5opt 40S RIBOSOMAL
PROTEIN S17,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 HIS k 145
ARG k 173
GLN k 148
HIS k 174
 U  E 731 ( 4.2A)
U  E 730 ( 3.3A)
U  E 731 ( 4.3A)
None
 1.48A 5kkzA-5optk:
undetectable
5kkzG-5optk:
undetectable		 5kkzA-5optk:
16.29
5kkzG-5optk:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5opt 40S RIBOSOMAL
PROTEIN S17,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 7 HIS k 145
ILE k 150
ARG k 173
HIS k 174
 U  E 731 ( 4.2A)
C  E 729 ( 4.8A)
U  E 730 ( 3.3A)
None
 1.17A 5kkzK-5optk:
undetectable
5kkzQ-5optk:
undetectable		 5kkzK-5optk:
16.29
5kkzQ-5optk:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5opt 40S RIBOSOMAL
PROTEIN S5, PUTATIVE
(Trypanosoma
cruzi) 		5 / 9 ASN O 134
VAL O 102
ILE O  28
ILE O  52
ILE O 137
 U  E2147 ( 3.1A)
None
None
None
None
 1.12A 5kqxB-5optO:
undetectable		 5kqxB-5optO:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 5opt RIBOSOMAL PROTEIN
S7, PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 GLU Q  86
LEU Q  83
ARG Q  81
ARG Q  40
 C  E1166 ( 3.3A)
None
None
C  E1167 ( 4.0A)
 1.21A 5l6eA-5optQ:
undetectable
5l6eB-5optQ:
undetectable		 5l6eA-5optQ:
21.46
5l6eB-5optQ:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5opt RIBOSOMAL PROTEIN
S19, PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 LEU o 127
LEU o 117
ILE o 108
GLN o  65
 None
 0.92A 5ljbA-5opto:
undetectable		 5ljbA-5opto:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5opt 40S RIBOSOMAL
PROTEIN SA
(Trypanosoma
cruzi) 		5 / 12 ASP f  17
PHE f 150
ARG f  66
ARG f 183
LEU f 181
 None
 1.50A 5m54B-5optf:
3.6		 5m54B-5optf:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5opt 40S RIBOSOMAL
PROTEIN S4
(Trypanosoma
cruzi) 		4 / 6 ASP L 140
HIS L  33
LEU L 121
HIS L 142
 None
None
None
C  E 120 ( 3.9A)
 0.93A 5nelB-5optL:
undetectable
5nelC-5optL:
undetectable		 5nelB-5optL:
21.74
5nelC-5optL:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5opt 40S RIBOSOMAL
PROTEIN S5, PUTATIVE
40S RIBOSOMAL
PROTEIN S16,
PUTATIVE
(Trypanosoma
cruzi;
Trypanosoma
cruzi) 		3 / 3 HIS r  65
SER r  63
LYS O   1
 None
 1.37A 5os7A-5optr:
undetectable		 5os7A-5optr:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5opt 40S RIBOSOMAL
PROTEIN S21,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 8 ARG g  65
THR g  30
ILE g  29
ALA g  60
 C  E1548 ( 3.4A)
None
None
None
 0.82A 5te8B-5optg:
undetectable		 5te8B-5optg:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5opt 40S RIBOSOMAL
PROTEIN SA
(Trypanosoma
cruzi) 		4 / 5 GLY f  29
THR f  30
ASN f  50
LYS f  31
 None
 1.23A 5x23A-5optf:
undetectable		 5x23A-5optf:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5opt 40S RIBOSOMAL
PROTEIN SA
(Trypanosoma
cruzi) 		4 / 6 PHE f 111
GLY f 109
THR f 110
ASN f 113
 None
A  E1789 ( 3.9A)
None
U  E1761 ( 2.8A)
 0.92A 5x24A-5optf:
undetectable		 5x24A-5optf:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5opt 40S RIBOSOMAL
PROTEIN S4
(Trypanosoma
cruzi) 		3 / 3 LYS L  72
PRO L  73
LYS L  75
 C  E 120 ( 3.2A)
None
G  E 335 ( 3.4A)
 0.72A 5y9yA-5optL:
undetectable		 5y9yA-5optL:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5opt ACTIVATED PROTEIN
KINASE C RECEPTOR,
PUTATIVE
(Trypanosoma
cruzi) 		4 / 6 GLN p 123
PHE p 105
LEU p  93
PHE p  81
 None
 1.14A 5z85P-5optp:
undetectable
5z85W-5optp:
undetectable		 5z85P-5optp:
19.02
5z85W-5optp:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5opt 40S RIBOSOMAL
PROTEIN S10,
PUTATIVE
40S RIBOSOMAL
PROTEIN S12
(Trypanosoma
cruzi) 		3 / 3 ARG i  52
ARG i 124
ARG n   8
 C  E1722 ( 2.9A)
None
G  E1723 ( 3.4A)
 0.90A 6bplA-5opti:
undetectable
6bplB-5opti:
undetectable		 6bplA-5opti:
22.14
6bplB-5opti:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5opt 40S RIBOSOMAL
PROTEIN S12
40S RIBOSOMAL
PROTEIN S10,
PUTATIVE
(Trypanosoma
cruzi;
Trypanosoma
cruzi) 		4 / 6 LEU i  43
TYR n  86
ASP n  11
GLN n  48
 None
None
U  E1725 ( 3.6A)
None
 1.40A 6djzC-5opti:
undetectable		 6djzC-5opti:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5opt 40S RIBOSOMAL
PROTEIN S2, PUTATIVE
40S RIBOSOMAL
PROTEIN S21,
PUTATIVE
(Trypanosoma
cruzi;
Trypanosoma
cruzi) 		3 / 3 LEU d  63
ASN g  13
LEU d 236
 None
 0.67A 6exiD-5optd:
undetectable		 6exiD-5optd:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5opt 40S RIBOSOMAL
PROTEIN SA
(Trypanosoma
cruzi) 		3 / 3 PHE f  91
ARG f  88
GLN f  95
 None
 1.13A 6g1pB-5optf:
undetectable		 6g1pB-5optf:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_B_ACTB403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5opt RIBOSOMAL PROTEIN
S19, PUTATIVE
(Trypanosoma
cruzi) 		3 / 3 PHE o  39
ARG o  62
GLN o  41
 None
None
A  E2031 ( 3.7A)
 1.10A 6g1pB-5opto:
undetectable		 6g1pB-5opto:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 5opt 40S RIBOSOMAL
PROTEIN S5, PUTATIVE
40S RIBOSOMAL
PROTEIN S16,
PUTATIVE
(Trypanosoma
cruzi;
Trypanosoma
cruzi) 		3 / 3 HIS r  65
SER r  63
LYS O   1
 None
 1.37A 6gmdB-5optr:
undetectable		 6gmdB-5optr:
18.26