SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5opz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)
5opz CHIX
(Serratia
marcescens)
4 / 7 LEU A  26
VAL A  22
GLY A  72
ASP A  76
None
None
None
ZN  A 201 (-2.2A)
0.87A 1t88A-5opzA:
undetectable
1t88A-5opzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)
5opz CHIX
(Serratia
marcescens)
4 / 8 LEU A  26
VAL A  22
GLY A  72
ASP A  76
None
None
None
ZN  A 201 (-2.2A)
0.79A 2a1oA-5opzA:
undetectable
2a1oA-5opzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5opz CHIX
(Serratia
marcescens)
4 / 7 ALA A  93
ILE A  95
TRP A 112
GLY A 122
None
0.99A 3v4tH-5opzA:
undetectable
3v4tH-5opzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RUJ_A_VDXA501_1
(VITAMIN D3 RECEPTOR
A)
5opz CHIX
(Serratia
marcescens)
5 / 12 VAL A  39
SER A  37
ILE A  95
SER A  15
VAL A  85
None
1.16A 4rujA-5opzA:
undetectable
4rujA-5opzA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)
5opz CHIX
(Serratia
marcescens)
3 / 3 ARG A  52
HIS A  69
ARG A  48
None
ZN  A 201 (-3.3A)
ZN  A 201 ( 4.5A)
1.16A 5iaoC-5opzA:
undetectable
5iaoC-5opzA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)
5opz CHIX
(Serratia
marcescens)
3 / 3 ARG A  52
HIS A  69
ARG A  48
None
ZN  A 201 (-3.3A)
ZN  A 201 ( 4.5A)
1.15A 5iaoF-5opzA:
undetectable
5iaoF-5opzA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)
5opz CHIX
(Serratia
marcescens)
4 / 8 SER A  44
ASP A  76
PRO A 123
TYR A  92
None
ZN  A 201 (-2.2A)
None
None
0.94A 5l1fA-5opzA:
undetectable
5l1fB-5opzA:
undetectable
5l1fA-5opzA:
7.64
5l1fB-5opzA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')
5opz CHIX
(Serratia
marcescens)
4 / 8 ILE A   9
ARG A  35
GLU A  16
SER A  15
None
1.00A 6c06C-5opzA:
undetectable
6c06C-5opzA:
undetectable