SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5or4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EVE_A_E20A2001_1
(ACETYLCHOLINESTERASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 GLY A 304
TYR A  95
LEU A 130
PHE A 122
HIS A 102
 None
None
None
None
CU  A2001 (-3.3A)
 1.50A 1eveA-5or4A:
undetectable		 1eveA-5or4A:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 12 LEU A 260
ALA A  10
LEU A  24
ALA A  28
ILE A 321
 None
 1.03A 1fk6A-5or4A:
undetectable		 1fk6A-5or4A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 12 PHE A 126
THR A 114
ILE A 365
GLN A 105
ALA A 360
 None
 1.40A 1fm4A-5or4A:
undetectable		 1fm4A-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 LEU A 351
ILE A 109
THR A 114
GLN A 105
 None
 1.13A 1kglA-5or4A:
undetectable		 1kglA-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 12 GLY A 287
GLY A 285
GLY A 282
GLY A 146
ASN A 151
 None
 0.84A 1n2xB-5or4A:
undetectable		 1n2xB-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 ARG A 239
TRP A  58
TRP A 143
PHE A 158
 None
 1.37A 1om5A-5or4A:
undetectable
1om5B-5or4A:
undetectable		 1om5A-5or4A:
10.39
1om5B-5or4A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.32A 1rs6A-5or4A:
undetectable
1rs6B-5or4A:
undetectable		 1rs6A-5or4A:
10.39
1rs6B-5or4A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 ASN A 324
TRP A 320
GLN A 331
 None
 1.43A 1xoqA-5or4A:
undetectable		 1xoqA-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1436_1
(CHITINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 ASP A 139
PHE A  61
ARG A  56
 None
 0.89A 2a3aA-5or4A:
undetectable		 2a3aA-5or4A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 ARG A 239
TRP A  58
TRP A 143
PHE A 158
 None
 1.38A 2g6hA-5or4A:
undetectable
2g6hB-5or4A:
undetectable		 2g6hA-5or4A:
10.44
2g6hB-5or4A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 THR A  93
TYR A  69
PHE A 204
LEU A 130
 None
 1.15A 2hzqA-5or4A:
undetectable		 2hzqA-5or4A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 GLY A 195
TYR A 171
SER A 194
 None
 0.66A 2xatA-5or4A:
undetectable		 2xatA-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 6 SER A  81
ARG A  92
PRO A  89
GLY A  90
 None
 0.94A 2y7pA-5or4A:
undetectable		 2y7pA-5or4A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.59A 2zweA-5or4A:
26.6
2zweB-5or4A:
undetectable		 2zweA-5or4A:
15.04
2zweB-5or4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 312
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.1A)
CU  A2002 (-3.2A)
None
 1.46A 2zweA-5or4A:
26.6
2zweB-5or4A:
undetectable		 2zweA-5or4A:
15.04
2zweB-5or4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.42A 2zweA-5or4A:
26.6
2zweB-5or4A:
undetectable		 2zweA-5or4A:
15.04
2zweB-5or4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.63A 2zwfA-5or4A:
26.7
2zwfB-5or4A:
undetectable		 2zwfA-5or4A:
15.04
2zwfB-5or4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 102
HIS A 288
HIS A 284
ASP A 316
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.45A 2zwfA-5or4A:
26.7
2zwfB-5or4A:
undetectable		 2zwfA-5or4A:
15.04
2zwfB-5or4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.49A 2zwfA-5or4A:
26.7
2zwfB-5or4A:
undetectable		 2zwfA-5or4A:
15.04
2zwfB-5or4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
None
 1.27A 2zwfA-5or4A:
26.7
2zwfB-5or4A:
undetectable		 2zwfA-5or4A:
15.04
2zwfB-5or4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.64A 2zwgA-5or4A:
26.7
2zwgB-5or4A:
undetectable		 2zwgA-5or4A:
15.04
2zwgB-5or4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.50A 2zwgA-5or4A:
26.7
2zwgB-5or4A:
undetectable		 2zwgA-5or4A:
15.04
2zwgB-5or4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_D_H4BD3902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.39A 3e7gC-5or4A:
0.3
3e7gD-5or4A:
0.4		 3e7gC-5or4A:
15.38
3e7gD-5or4A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 311
HIS A 110
HIS A 119
HIS A 102
 None
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
 1.10A 3likA-5or4A:
undetectable		 3likA-5or4A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 ILE A 109
HIS A 284
HIS A 288
HIS A 312
 None
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2002 (-3.1A)
 0.95A 3ljgA-5or4A:
undetectable		 3ljgA-5or4A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 311
HIS A 110
HIS A 119
HIS A 102
 None
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
 1.09A 3lkaA-5or4A:
undetectable		 3lkaA-5or4A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 ILE A 123
ILE A 315
SER A 302
HIS A 102
HIS A 110
 None
None
None
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
 1.24A 3o1cA-5or4A:
undetectable		 3o1cA-5or4A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 ILE A 123
ILE A 315
SER A 302
HIS A 102
HIS A 110
 None
None
None
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
 1.27A 3o1xA-5or4A:
undetectable		 3o1xA-5or4A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 ILE A 123
ILE A 315
SER A 302
HIS A 102
HIS A 110
 None
None
None
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
 1.20A 3qgzA-5or4A:
undetectable		 3qgzA-5or4A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 HIS A 110
HIS A 119
HIS A 102
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
 0.35A 3qpkA-5or4A:
undetectable		 3qpkA-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 HIS A 110
HIS A 119
HIS A 102
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
 0.35A 3qpkB-5or4A:
undetectable		 3qpkB-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 THR A 231
GLY A  90
GLY A 212
PRO A 213
ASP A  96
 None
 1.34A 3t8nD-5or4A:
undetectable
3t8nF-5or4A:
undetectable		 3t8nD-5or4A:
undetectable
3t8nF-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 12 LEU A 180
GLY A 292
ILE A 178
ILE A 245
LEU A 216
 None
 0.96A 3uj6A-5or4A:
undetectable		 3uj6A-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 LEU A  49
LEU A  52
THR A  32
TRP A 320
 None
 1.32A 4do3A-5or4A:
undetectable		 4do3A-5or4A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 12 GLN A 175
GLY A 292
ILE A 245
LYS A 238
PRO A 219
 None
 0.91A 4gc9A-5or4A:
undetectable		 4gc9A-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 102
HIS A 110
HIS A 284
HIS A 288
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
 0.34A 4p6sA-5or4A:
28.1		 4p6sA-5or4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 110
HIS A 284
HIS A 288
VAL A 299
 CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.72A 4p6sA-5or4A:
28.1		 4p6sA-5or4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 102
HIS A 110
HIS A 284
HIS A 288
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
 0.44A 4p6sB-5or4A:
28.0		 4p6sB-5or4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 110
HIS A 284
HIS A 288
VAL A 299
 CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.73A 4p6sB-5or4A:
28.0		 4p6sB-5or4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 LEU A 258
MET A 314
TYR A 249
 None
 0.95A 4p6xG-5or4A:
undetectable		 4p6xG-5or4A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.30A 4uchA-5or4A:
0.2
4uchB-5or4A:
undetectable		 4uchA-5or4A:
10.39
4uchB-5or4A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.41A 4v3wA-5or4A:
undetectable
4v3wB-5or4A:
undetectable		 4v3wA-5or4A:
10.39
4v3wB-5or4A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 9 HIS A 284
TYR A 249
GLY A 286
GLY A 287
HIS A 311
 CU  A2002 (-3.2A)
None
None
None
None
 1.45A 5f8yA-5or4A:
undetectable		 5f8yA-5or4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 9 HIS A 284
TYR A 249
GLY A 286
GLY A 287
HIS A 311
 CU  A2002 (-3.2A)
None
None
None
None
 1.42A 5f8yB-5or4A:
undetectable		 5f8yB-5or4A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 102
HIS A 110
HIS A 284
HIS A 288
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
 0.34A 5i3aA-5or4A:
27.8		 5i3aA-5or4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 110
HIS A 284
HIS A 288
VAL A 299
 CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.66A 5i3aA-5or4A:
27.8		 5i3aA-5or4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 102
HIS A 110
HIS A 284
HIS A 288
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
 0.38A 5i3aB-5or4A:
28.0		 5i3aB-5or4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 110
HIS A 284
HIS A 288
VAL A 299
 CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.64A 5i3aB-5or4A:
28.0		 5i3aB-5or4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 102
HIS A 110
HIS A 284
HIS A 288
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
 0.38A 5i3bA-5or4A:
27.9		 5i3bA-5or4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 HIS A 110
HIS A 284
HIS A 288
VAL A 299
 CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.70A 5i3bA-5or4A:
27.9		 5i3bA-5or4A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.38A 5m8nA-5or4A:
26.4		 5m8nA-5or4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 HIS A 102
HIS A 110
HIS A 312
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.1A)
CU  A2002 (-3.2A)
None
 1.42A 5m8nA-5or4A:
26.4		 5m8nA-5or4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 HIS A 102
TYR A 111
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
None
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.20A 5m8nA-5or4A:
26.4		 5m8nA-5or4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_A_MMSA514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 HIS A 288
HIS A 312
HIS A 110
HIS A 102
SER A 302
 CU  A2002 (-3.2A)
CU  A2002 (-3.1A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
None
 1.50A 5m8nA-5or4A:
26.4		 5m8nA-5or4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.40A 5m8nB-5or4A:
26.4		 5m8nB-5or4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_B_MMSB515_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 10 HIS A 102
TYR A 111
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
None
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.23A 5m8nB-5or4A:
26.4		 5m8nB-5or4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 9 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.39A 5m8nC-5or4A:
26.3		 5m8nC-5or4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8N_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 9 HIS A 102
TYR A 111
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
None
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.20A 5m8nC-5or4A:
26.3		 5m8nC-5or4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 7 HIS A 110
HIS A 284
HIS A 288
VAL A 299
SER A 302
 CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
None
 0.69A 5m8rA-5or4A:
26.5		 5m8rA-5or4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 7 HIS A 110
HIS A 312
HIS A 288
VAL A 299
SER A 302
 CU  A2001 (-3.3A)
CU  A2002 (-3.1A)
CU  A2002 (-3.2A)
None
None
 1.37A 5m8rA-5or4A:
26.5		 5m8rA-5or4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 8 HIS A 110
HIS A 284
HIS A 288
VAL A 299
SER A 302
 CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
None
 0.70A 5m8rB-5or4A:
26.4		 5m8rB-5or4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 8 HIS A 110
HIS A 284
HIS A 288
VAL A 299
SER A 302
 CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
None
 0.73A 5m8rC-5or4A:
26.5		 5m8rC-5or4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 8 HIS A 110
HIS A 284
HIS A 288
VAL A 299
SER A 302
 CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
None
 0.71A 5m8rD-5or4A:
26.5		 5m8rD-5or4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 8 HIS A 110
HIS A 312
VAL A 299
SER A 302
 CU  A2001 (-3.3A)
CU  A2002 (-3.1A)
None
None
 1.00A 5m8rD-5or4A:
26.5		 5m8rD-5or4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 HIS A 110
HIS A 119
HIS A 102
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
 0.38A 5migA-5or4A:
undetectable		 5migA-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 ILE A 109
HIS A 284
HIS A 288
HIS A 312
 None
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2002 (-3.1A)
 0.99A 5n5kA-5or4A:
undetectable		 5n5kA-5or4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 PHE A 308
GLY A 304
GLY A 296
HIS A 288
 None
None
None
CU  A2002 (-3.2A)
 0.99A 5n9xA-5or4A:
undetectable		 5n9xA-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 4 LEU A  52
LEU A  49
SER A  35
ALA A  37
 None
 0.91A 5uunA-5or4A:
undetectable		 5uunA-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.66A 5z0fA-5or4A:
26.7
5z0fB-5or4A:
undetectable		 5z0fA-5or4A:
16.25
5z0fB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
None
 1.28A 5z0fA-5or4A:
26.7
5z0fB-5or4A:
undetectable		 5z0fA-5or4A:
16.25
5z0fB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.62A 5z0gA-5or4A:
26.7
5z0gB-5or4A:
undetectable		 5z0gA-5or4A:
16.25
5z0gB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 102
HIS A 288
HIS A 284
ASP A 316
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.49A 5z0gA-5or4A:
26.7
5z0gB-5or4A:
undetectable		 5z0gA-5or4A:
16.25
5z0gB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
None
 1.30A 5z0gA-5or4A:
26.7
5z0gB-5or4A:
undetectable		 5z0gA-5or4A:
16.25
5z0gB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.63A 5z0hA-5or4A:
26.7
5z0hB-5or4A:
undetectable		 5z0hA-5or4A:
16.25
5z0hB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.63A 5z0iA-5or4A:
26.8
5z0iB-5or4A:
undetectable		 5z0iA-5or4A:
16.25
5z0iB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.49A 5z0iA-5or4A:
26.8
5z0iB-5or4A:
undetectable		 5z0iA-5or4A:
16.25
5z0iB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
None
 1.27A 5z0iA-5or4A:
26.8
5z0iB-5or4A:
undetectable		 5z0iA-5or4A:
16.25
5z0iB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.61A 5z0jA-5or4A:
26.7
5z0jB-5or4A:
undetectable		 5z0jA-5or4A:
16.25
5z0jB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 102
HIS A 288
HIS A 284
ASP A 316
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.47A 5z0jA-5or4A:
26.7
5z0jB-5or4A:
undetectable		 5z0jA-5or4A:
16.25
5z0jB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.46A 5z0jA-5or4A:
26.7
5z0jB-5or4A:
undetectable		 5z0jA-5or4A:
16.25
5z0jB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
None
 1.29A 5z0jA-5or4A:
26.7
5z0jB-5or4A:
undetectable		 5z0jA-5or4A:
16.25
5z0jB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.61A 5z0kA-5or4A:
26.7
5z0kB-5or4A:
undetectable		 5z0kA-5or4A:
16.25
5z0kB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.45A 5z0kA-5or4A:
26.7
5z0kB-5or4A:
undetectable		 5z0kA-5or4A:
16.25
5z0kB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.66A 5z0lA-5or4A:
26.7
5z0lB-5or4A:
undetectable		 5z0lA-5or4A:
16.25
5z0lB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 110
HIS A 119
HIS A 288
HIS A 284
VAL A 283
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.50A 5z0lA-5or4A:
26.7
5z0lB-5or4A:
undetectable		 5z0lA-5or4A:
16.25
5z0lB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 288
HIS A 284
HIS A 110
HIS A 102
SER A 302
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
None
 1.29A 5z0lA-5or4A:
26.7
5z0lB-5or4A:
undetectable		 5z0lA-5or4A:
16.25
5z0lB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 110
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 0.69A 5z0mA-5or4A:
26.7
5z0mB-5or4A:
undetectable		 5z0mA-5or4A:
16.25
5z0mB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 11 HIS A 102
HIS A 119
HIS A 284
HIS A 288
SER A 302
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
 1.47A 5z0mA-5or4A:
26.7
5z0mB-5or4A:
undetectable		 5z0mA-5or4A:
16.25
5z0mB-5or4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		3 / 3 HIS A 284
HIS A 288
HIS A 312
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2002 (-3.1A)
 0.26A 5zrdA-5or4A:
2.9		 5zrdA-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		5 / 5 HIS A 284
HIS A 288
PHE A 308
HIS A 311
HIS A 312
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
None
CU  A2002 (-3.1A)
 0.43A 5zrdB-5or4A:
20.5		 5zrdB-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 102
HIS A 110
HIS A 119
PHE A 308
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
None
 0.53A 5zrdB-5or4A:
20.5		 5zrdB-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 284
HIS A 288
HIS A 312
PHE A 115
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2002 (-3.1A)
None
 0.98A 5zrdB-5or4A:
20.5		 5zrdB-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 4 HIS A 284
HIS A 288
HIS A 311
HIS A 312
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
CU  A2002 (-3.1A)
 0.43A 5zrdC-5or4A:
3.3		 5zrdC-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 102
HIS A 110
HIS A 119
PHE A 308
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
None
 0.57A 5zrdC-5or4A:
3.3		 5zrdC-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 284
HIS A 288
HIS A 312
PHE A 115
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2002 (-3.1A)
None
 1.03A 5zrdC-5or4A:
3.3		 5zrdC-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 102
HIS A 110
HIS A 119
PHE A 308
 CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
CU  A2001 (-3.3A)
None
 0.55A 5zrdD-5or4A:
4.0		 5zrdD-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 5 HIS A 284
HIS A 288
HIS A 312
PHE A 115
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
CU  A2002 (-3.1A)
None
 1.00A 5zrdD-5or4A:
4.0		 5zrdD-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 4 HIS A 284
HIS A 288
HIS A 311
HIS A 312
 CU  A2002 (-3.2A)
CU  A2002 (-3.2A)
None
CU  A2002 (-3.1A)
 0.45A 5zrdD-5or4A:
4.0		 5zrdD-5or4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 ARG A 239
TRP A  58
TRP A 143
PHE A 158
 None
 1.36A 6auuA-5or4A:
undetectable
6auuB-5or4A:
undetectable		 6auuA-5or4A:
17.07
6auuB-5or4A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV6_B_H4BB503_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5or4 CATECHOL OXIDASE
(Aspergillus
oryzae) 		4 / 7 TRP A  58
TRP A 143
PHE A 158
ARG A 239
 None
 1.37A 6av6A-5or4A:
undetectable
6av6B-5or4A:
undetectable		 6av6A-5or4A:
22.47
6av6B-5or4A:
22.47