SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5or7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 5or7 CAPSID PROTEIN
(Norwalk
virus) 		5 / 11 ILE A 458
PHE A 432
LEU A 232
PRO A 233
ILE A 497
 None
 1.01A 1dg5A-5or7A:
undetectable		 1dg5A-5or7A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5or7 CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 SER A 282
GLY A 283
ARG A 392
 None
 0.65A 1t9wA-5or7A:
undetectable		 1t9wA-5or7A:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 5or7 CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 PRO A 415
GLY A 320
TYR A 370
 None
 0.74A 2vouA-5or7A:
undetectable		 2vouA-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5or7 CAPSID PROTEIN
CMRF35-LIKE MOLECULE
1
(Mus
musculus;
Norwalk
virus) 		4 / 7 PRO A 361
SER C  43
ILE A 358
GLY A 400
 NA  A 601 (-4.6A)
None
None
None
 0.96A 2y7kA-5or7A:
undetectable		 2y7kA-5or7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5or7 CAPSID PROTEIN
(Norwalk
virus) 		4 / 8 GLU A 488
LEU A 474
PHE A 525
ALA A 528
 None
 1.01A 3ax9B-5or7A:
undetectable		 3ax9B-5or7A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5or7 CAPSID PROTEIN
(Norwalk
virus) 		5 / 12 LEU A 491
TYR A 492
GLY A 421
GLY A 495
LEU A 453
 None
 1.18A 3e23A-5or7A:
undetectable		 3e23A-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5or7 CAPSID PROTEIN
(Norwalk
virus) 		5 / 11 GLY A 411
THR A 363
GLY A 360
PRO A 361
ASP A 366
 None
None
None
NA  A 601 (-4.6A)
NA  C 401 (-3.7A)
 1.34A 3t8nD-5or7A:
undetectable
3t8nF-5or7A:
undetectable		 3t8nD-5or7A:
undetectable
3t8nF-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)		 5or7 CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 ASP A 450
THR A 279
PRO A 280
 None
 0.67A 3tkgD-5or7A:
undetectable		 3tkgD-5or7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5or7 CAPSID PROTEIN
CMRF35-LIKE MOLECULE
1
(Norwalk
virus;
Mus
musculus) 		4 / 6 GLY A 333
ILE A 358
GLN A 334
SER C  43
 None
 0.73A 4d39B-5or7A:
undetectable		 4d39B-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 5or7 CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 PRO A 319
TYR A 370
GLY A 372
 None
 0.59A 4g2zA-5or7A:
undetectable		 4g2zA-5or7A:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5or7 CAPSID PROTEIN
CMRF35-LIKE MOLECULE
1
(Norwalk
virus;
Mus
musculus) 		4 / 6 GLY A 333
ILE A 358
GLN A 334
SER C  43
 None
 0.92A 4kcnA-5or7A:
undetectable		 4kcnA-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5or7 CAPSID PROTEIN
(Norwalk
virus) 		4 / 8 THR A 279
PRO A 280
VAL A 286
SER A 287
 None
 1.14A 4qknA-5or7A:
undetectable		 4qknA-5or7A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 5or7 CAPSID PROTEIN
(Norwalk
virus) 		5 / 11 LEU A 429
VAL A 428
PHE A 487
LEU A 253
ARG A 431
 None
 1.20A 4zbqA-5or7A:
undetectable		 4zbqA-5or7A:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 5or7 CAPSID PROTEIN
CMRF35-LIKE MOLECULE
1
(Norwalk
virus;
Mus
musculus) 		3 / 3 THR A 363
ASP C  98
GLU C  49
 None
NA  C 401 (-2.9A)
None
 0.79A 5fa8A-5or7A:
undetectable		 5fa8A-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5or7 CAPSID PROTEIN
(Norwalk
virus) 		5 / 6 GLY A 327
ASP A 403
ILE A 420
ARG A 268
TYR A 408
 None
None
None
None
NA  A 600 (-4.5A)
 1.40A 5iwuA-5or7A:
undetectable		 5iwuA-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 5or7 CAPSID PROTEIN
(Norwalk
virus) 		3 / 3 ILE A 405
ASN A 266
CYH A 451
 None
NA  A 600 ( 4.2A)
None
 0.93A 6bp4A-5or7A:
undetectable		 6bp4A-5or7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_A_LLLA302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 5or7 CAPSID PROTEIN
CMRF35-LIKE MOLECULE
1
(Norwalk
virus;
Mus
musculus) 		5 / 10 TYR C  34
ASP C  98
ASP A 410
ASP C  51
THR C  50
 None
NA  C 401 (-2.9A)
None
None
NA  C 402 (-3.0A)
 1.48A 6mn1A-5or7C:
undetectable		 6mn1A-5or7C:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 5or7 CAPSID PROTEIN
CMRF35-LIKE MOLECULE
1
(Norwalk
virus;
Mus
musculus) 		5 / 10 TYR C  34
ASP C  98
ASP A 410
ASP C  51
THR C  50
 None
NA  C 401 (-2.9A)
None
None
NA  C 402 (-3.0A)
 1.46A 6mn1B-5or7C:
undetectable		 6mn1B-5or7C:
19.75