SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5osq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		4 / 6 VAL A   9
VAL A  51
ILE A  61
ASN A 268
 None
 0.95A 1e06A-5osqA:
undetectable		 1e06A-5osqA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		5 / 11 THR A  94
GLN A 326
ALA A 325
ALA A 304
ALA A 302
 None
 1.07A 2f16H-5osqA:
undetectable
2f16I-5osqA:
undetectable		 2f16H-5osqA:
18.47
2f16I-5osqA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		5 / 11 THR A  94
GLN A 326
ALA A 325
ALA A 304
ALA A 302
 None
 1.06A 2f16V-5osqA:
undetectable
2f16W-5osqA:
undetectable		 2f16V-5osqA:
18.47
2f16W-5osqA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		4 / 6 PHE A 259
ALA A 163
LEU A 248
PRO A 160
 None
 0.95A 3bgdA-5osqA:
undetectable		 3bgdA-5osqA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		4 / 7 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.66A 3bjwC-5osqA:
undetectable		 3bjwC-5osqA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		4 / 8 VAL A 111
GLY A 301
PRO A 230
LYS A 306
 None
 0.89A 3bjwA-5osqA:
undetectable		 3bjwA-5osqA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		4 / 6 PRO A 127
LEU A 148
ALA A 224
PRO A 126
 None
 1.27A 3gv1A-5osqA:
undetectable
3gv1C-5osqA:
undetectable		 3gv1A-5osqA:
16.63
3gv1C-5osqA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		4 / 6 LEU A 148
ALA A 224
PRO A 126
PRO A 127
 None
 1.25A 3gv1A-5osqA:
undetectable
3gv1B-5osqA:
undetectable		 3gv1A-5osqA:
16.63
3gv1B-5osqA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		5 / 12 VAL A 344
GLY A 188
ALA A 189
LEU A 193
LEU A 161
 None
 1.05A 3hs6A-5osqA:
undetectable		 3hs6A-5osqA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		9 / 12 ASP A  15
LYS A  16
GLU A  45
GLU A  46
ALA A  64
ASP A  66
ARG A  67
GLU A 112
TRP A 231
 MAL  A 501 (-2.5A)
MAL  A 501 (-2.1A)
None
None
MAL  A 501 (-3.0A)
MAL  A 501 (-2.4A)
MAL  A 501 (-4.0A)
MAL  A 501 (-2.9A)
MAL  A 501 ( 3.3A)
 0.62A 3jyrA-5osqA:
56.7		 3jyrA-5osqA:
75.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		9 / 12 ASP A  15
LYS A  16
GLU A  45
GLU A  46
ALA A  64
ASP A  66
GLU A 112
PRO A 155
TRP A 231
 MAL  A 501 (-2.5A)
MAL  A 501 (-2.1A)
None
None
MAL  A 501 (-3.0A)
MAL  A 501 (-2.4A)
MAL  A 501 (-2.9A)
MAL  A 501 (-3.0A)
MAL  A 501 ( 3.3A)
 0.30A 3jyrA-5osqA:
56.7		 3jyrA-5osqA:
75.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		6 / 7 ASN A  13
TRP A  63
GLU A 154
TYR A 156
MET A 331
TRP A 341
 MAL  A 501 (-4.3A)
MAL  A 501 (-3.8A)
MAL  A 501 (-3.4A)
MAL  A 501 (-2.7A)
MAL  A 501 ( 3.5A)
MAL  A 501 (-2.6A)
 0.25A 3jyrA-5osqA:
56.7		 3jyrA-5osqA:
75.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		5 / 11 THR A  94
GLN A 326
ALA A 325
ALA A 304
ALA A 302
 None
 1.10A 3mg0V-5osqA:
undetectable
3mg0W-5osqA:
undetectable		 3mg0V-5osqA:
18.47
3mg0W-5osqA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		5 / 12 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.99A 3n8yB-5osqA:
undetectable		 3n8yB-5osqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 MAL  A 501 ( 4.4A)
None
None
MAL  A 501 (-2.9A)
None
 0.86A 3tbgB-5osqA:
undetectable		 3tbgB-5osqA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		5 / 12 PHE A 157
GLY A 301
LEU A 300
GLU A 112
ALA A 232
 MAL  A 501 ( 4.4A)
None
None
MAL  A 501 (-2.9A)
None
 0.85A 3tbgD-5osqA:
undetectable		 3tbgD-5osqA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		5 / 12 ALA A 232
TYR A  18
TYR A 211
ASN A 235
GLY A 229
 None
 1.36A 3vwqA-5osqA:
undetectable		 3vwqA-5osqA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		4 / 4 ILE A 117
VAL A 247
VAL A 245
ARG A 317
 None
 1.36A 4m6tA-5osqA:
undetectable		 4m6tA-5osqA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		4 / 5 ASN A 268
ALA A  52
GLY A  57
ASP A  15
 None
None
None
MAL  A 501 (-2.5A)
 0.99A 4n48A-5osqA:
undetectable		 4n48A-5osqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		5 / 9 ALA A 265
ALA A 106
LEU A 104
LEU A 263
VAL A 262
 None
 1.14A 4or0B-5osqA:
undetectable		 4or0B-5osqA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		4 / 4 VAL A 111
ALA A 113
ILE A 318
THR A 321
 None
 1.20A 5e4dB-5osqA:
undetectable		 5e4dB-5osqA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		3 / 3 TYR A 156
ASN A 228
LEU A 114
 MAL  A 501 (-2.7A)
None
None
 0.81A 6b58A-5osqA:
undetectable		 6b58A-5osqA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3
(Escherichia
coli;
Mus
musculus) 		5 / 11 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.36A 6bm5A-5osqA:
undetectable		 6bm5A-5osqA:
23.60