SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ot0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		5 / 10 THR A 298
ALA A 295
ALA A  94
LEU A 108
ILE A 140
 None
 1.19A 1claA-5ot0A:
undetectable		 1claA-5ot0A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 8 LEU A 281
VAL A 269
GLY A 289
MET A 291
 None
 0.86A 1hrkA-5ot0A:
3.6		 1hrkA-5ot0A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 8 LEU A 281
VAL A 269
GLY A 289
MET A 291
 None
 0.87A 1hrkB-5ot0A:
3.4		 1hrkB-5ot0A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		5 / 10 LEU A   4
ALA A  27
ILE A  12
GLY A  10
GLY A   9
 None
None
None
PO4  A 401 (-3.5A)
None
 0.99A 1k6cA-5ot0A:
undetectable		 1k6cA-5ot0A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 8 LEU A 281
VAL A 269
GLY A 289
MET A 291
 None
 0.89A 2po5A-5ot0A:
4.9		 2po5A-5ot0A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 8 ALA A  94
SER A  96
GLY A 151
ALA A 295
 None
 0.75A 2vh3B-5ot0A:
undetectable		 2vh3B-5ot0A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_D_TOPD1158_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A  68
LEU A   6
LEU A  95
ILE A  99
PHE A  73
 None
 1.08A 2w9sD-5ot0A:
undetectable		 2w9sD-5ot0A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		5 / 10 ALA A  68
LEU A   6
LEU A  95
ILE A  99
PHE A  73
 None
 1.11A 2w9sF-5ot0A:
undetectable		 2w9sF-5ot0A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 6 ASP A 121
ARG A 124
ILE A 115
SER A  14
 None
 0.96A 3ckzA-5ot0A:
undetectable		 3ckzA-5ot0A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		5 / 9 THR A  82
VAL A 142
SER A 167
ILE A  12
GLY A  84
 None
None
None
None
PO4  A 401 (-3.0A)
 1.15A 3cv9A-5ot0A:
undetectable		 3cv9A-5ot0A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 5 ASP A  48
ILE A  30
VAL A  80
THR A  91
 None
 1.22A 3eigA-5ot0A:
undetectable		 3eigA-5ot0A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 7 PRO A 102
ILE A 140
LEU A 108
ILE A  79
 None
 0.85A 3p50A-5ot0A:
undetectable		 3p50A-5ot0A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 7 PRO A 102
ILE A 140
LEU A 108
ILE A  79
 None
 0.87A 3p50B-5ot0A:
undetectable		 3p50B-5ot0A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 7 PRO A 102
ILE A 140
LEU A 108
ILE A  79
 None
 0.84A 3p50C-5ot0A:
undetectable		 3p50C-5ot0A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 7 PRO A 102
ILE A 140
LEU A 108
ILE A  79
 None
 0.86A 3p50D-5ot0A:
undetectable		 3p50D-5ot0A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 7 PRO A 102
ILE A 140
LEU A 108
ILE A  79
 None
 0.86A 3p50E-5ot0A:
undetectable		 3p50E-5ot0A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_D_T1CD401_1
(TETX2 PROTEIN)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		5 / 10 ASP A 197
HIS A 306
ARG A 100
ASN A 101
GLY A 139
 None
 1.39A 3v3oD-5ot0A:
undetectable		 3v3oD-5ot0A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 8 THR A   8
ILE A  81
VAL A 106
GLY A  66
 None
 0.90A 4eq4B-5ot0A:
1.3		 4eq4B-5ot0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		5 / 12 ARG A 278
GLY A 284
ALA A 235
GLY A 237
GLU A 275
 None
 1.10A 4r29C-5ot0A:
undetectable		 4r29C-5ot0A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		5 / 12 ALA A 295
THR A 296
GLY A 151
SER A  92
ALA A  89
 None
 1.22A 4ypmA-5ot0A:
undetectable		 4ypmA-5ot0A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 8 THR A  82
SER A  14
ALA A 122
SER A 120
 None
 1.08A 5l5fY-5ot0A:
undetectable
5l5fZ-5ot0A:
undetectable		 5l5fY-5ot0A:
22.42
5l5fZ-5ot0A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		5 / 12 SER A 250
GLU A 251
LEU A 246
ILE A 238
VAL A 258
 None
 1.30A 5vlmB-5ot0A:
undetectable		 5vlmB-5ot0A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		5 / 12 GLY A 289
GLY A 236
VAL A 259
ALA A 235
TYR A 274
 None
 1.06A 5x7fA-5ot0A:
undetectable		 5x7fA-5ot0A:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 5ot0 L-ASPARAGINASE
(Thermococcus
kodakarensis) 		4 / 4 PHE A 137
LEU A 108
LEU A 150
VAL A 106
 None
 1.32A 5xxiA-5ot0A:
undetectable		 5xxiA-5ot0A:
21.10