SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ot1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 TYR A 698
GLU A 732
PHE A 708
ARG A 696
None
1.42A 1b2iA-5ot1A:
undetectable
1b2iA-5ot1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA1001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
6 / 12 TYR A 383
LEU A 471
ASP A 503
HIS A 600
ASP A 601
ARG A 661
None
0.86A 1dedA-5ot1A:
35.3
1dedA-5ot1A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
7 / 12 HIS A 381
TYR A 383
ARG A 501
ASP A 503
GLU A 534
HIS A 600
ARG A 661
None
0.80A 1dedB-5ot1A:
34.3
1dedB-5ot1A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
7 / 12 TYR A 383
LEU A 471
ARG A 501
ASP A 503
GLU A 534
HIS A 600
ARG A 661
None
0.82A 1dedB-5ot1A:
34.3
1dedB-5ot1A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_B_QPSB1501_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
7 / 12 TYR A 383
LEU A 471
ARG A 501
ASP A 503
HIS A 600
ASP A 601
ARG A 661
None
0.78A 1dedB-5ot1A:
34.3
1dedB-5ot1A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 6 GLN A 284
ASP A 200
VAL A 204
HIS A 711
None
1.19A 1ekjG-5ot1A:
undetectable
1ekjH-5ot1A:
undetectable
1ekjG-5ot1A:
undetectable
1ekjH-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 4 ILE A 416
LEU A 518
VAL A 522
ILE A 493
None
0.82A 1fm6D-5ot1A:
undetectable
1fm6D-5ot1A:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 TYR A 346
LYS A 394
LEU A 318
SER A 379
None
1.26A 1hk2A-5ot1A:
undetectable
1hk2A-5ot1A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 ARG A 558
ASN A 563
ASP A 608
LYS A 566
None
1.24A 1hwiB-5ot1A:
undetectable
1hwiB-5ot1A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_1
(HMG-COA REDUCTASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 ARG A 558
ASN A 563
ASP A 608
LYS A 566
None
1.10A 1hwiC-5ot1A:
undetectable
1hwiC-5ot1A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_2
(HMG-COA REDUCTASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 ARG A 558
ASN A 563
ASP A 608
LYS A 566
None
1.10A 1hwiD-5ot1A:
undetectable
1hwiD-5ot1A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 ARG A 558
ASN A 563
ASP A 608
LYS A 566
None
1.12A 1hwkA-5ot1A:
undetectable
1hwkA-5ot1A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 ARG A 558
ASN A 563
ASP A 608
LYS A 566
None
1.11A 1hwkC-5ot1A:
undetectable
1hwkC-5ot1A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 ARG A 558
ASN A 563
ASP A 608
LYS A 566
None
1.11A 1hwkD-5ot1A:
undetectable
1hwkD-5ot1A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
3 / 3 ARG A 501
ILE A 535
TRP A 536
None
1.22A 1m8eB-5ot1A:
undetectable
1m8eB-5ot1A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA735_1
(ALPHA AMYLASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
7 / 12 TYR A 383
HIS A 423
ARG A 501
ASP A 503
GLU A 534
HIS A 600
ASP A 601
None
0.40A 1mxdA-5ot1A:
26.2
1mxdA-5ot1A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 6 ARG A 501
ILE A 535
TRP A 536
GLU A 507
None
1.19A 1nsiA-5ot1A:
undetectable
1nsiB-5ot1A:
undetectable
1nsiA-5ot1A:
13.54
1nsiB-5ot1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 6 GLU A 507
ARG A 501
ILE A 535
TRP A 536
None
1.24A 1nsiA-5ot1A:
undetectable
1nsiB-5ot1A:
undetectable
1nsiA-5ot1A:
13.54
1nsiB-5ot1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 6 GLU A 507
ARG A 501
ILE A 535
TRP A 536
None
1.31A 1nsiC-5ot1A:
undetectable
1nsiD-5ot1A:
undetectable
1nsiC-5ot1A:
13.54
1nsiD-5ot1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OM5_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 ARG A 501
TRP A 536
TRP A 465
GLU A 507
None
1.38A 1om5A-5ot1A:
undetectable
1om5B-5ot1A:
undetectable
1om5A-5ot1A:
14.43
1om5B-5ot1A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
6 / 12 PHE A 419
VAL A 508
PHE A 514
VAL A 502
VAL A 481
HIS A 423
None
1.48A 1q23H-5ot1A:
undetectable
1q23I-5ot1A:
undetectable
1q23H-5ot1A:
17.56
1q23I-5ot1A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 TRP A 465
GLU A 507
ARG A 501
TRP A 536
None
1.35A 1rs6A-5ot1A:
undetectable
1rs6B-5ot1A:
undetectable
1rs6A-5ot1A:
14.43
1rs6B-5ot1A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 10 LEU A 485
ALA A 489
ILE A 486
VAL A 502
PHE A 514
None
0.96A 1xp0A-5ot1A:
undetectable
1xp0A-5ot1A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G6H_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 ARG A 501
TRP A 536
TRP A 465
GLU A 507
None
1.32A 2g6hA-5ot1A:
undetectable
2g6hB-5ot1A:
undetectable
2g6hA-5ot1A:
11.19
2g6hB-5ot1A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 HIS A 676
MET A 705
ALA A 679
LEU A 683
ALA A 681
None
1.09A 2jjpA-5ot1A:
undetectable
2jjpA-5ot1A:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 ARG A 501
ILE A 535
TRP A 536
GLU A 507
None
1.18A 2nsiA-5ot1A:
undetectable
2nsiB-5ot1A:
undetectable
2nsiA-5ot1A:
13.54
2nsiB-5ot1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 GLU A 507
ARG A 501
ILE A 535
TRP A 536
None
1.21A 2nsiA-5ot1A:
undetectable
2nsiB-5ot1A:
undetectable
2nsiA-5ot1A:
13.54
2nsiB-5ot1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 ARG A 501
ILE A 535
TRP A 536
GLU A 507
None
1.23A 2nsiC-5ot1A:
undetectable
2nsiD-5ot1A:
undetectable
2nsiC-5ot1A:
13.54
2nsiD-5ot1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 GLU A 507
ARG A 501
ILE A 535
TRP A 536
None
1.22A 2nsiC-5ot1A:
undetectable
2nsiD-5ot1A:
undetectable
2nsiC-5ot1A:
13.54
2nsiD-5ot1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_2
(MINERALOCORTICOID
RECEPTOR)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 4 LEU A 632
LEU A 562
MET A 705
MET A 577
None
1.27A 2oaxB-5ot1A:
undetectable
2oaxB-5ot1A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 TYR A 346
ASP A 384
TYR A 386
HIS A 315
None
1.39A 2pncA-5ot1A:
undetectable
2pncA-5ot1A:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_4
(PROTEASE RETROPEPSIN)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
3 / 3 ASP A 498
THR A 639
PRO A 640
None
0.65A 2q64B-5ot1A:
undetectable
2q64B-5ot1A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 4 ALA A 583
TYR A 581
ALA A 194
TYR A 585
None
1.27A 2wlkA-5ot1A:
3.6
2wlkB-5ot1A:
3.3
2wlkA-5ot1A:
16.42
2wlkB-5ot1A:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 ILE A 371
PHE A 404
ARG A 414
THR A 367
None
1.05A 3ag2N-5ot1A:
undetectable
3ag2W-5ot1A:
undetectable
3ag2N-5ot1A:
undetectable
3ag2W-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
6 / 12 ARG A 501
ASP A 503
ASN A 506
GLU A 534
HIS A 600
ASP A 601
None
1.43A 3aicA-5ot1A:
8.3
3aicA-5ot1A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
6 / 12 ARG A 501
ASP A 503
ASN A 506
GLU A 534
HIS A 600
ASP A 601
None
1.48A 3aicB-5ot1A:
8.6
3aicB-5ot1A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_C_ACRC5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
6 / 12 ARG A 501
ASP A 503
GLU A 534
HIS A 600
ASP A 601
TYR A 383
None
0.78A 3aicC-5ot1A:
8.0
3aicC-5ot1A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_D_ACRD5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
6 / 12 ARG A 501
ASP A 503
ASN A 506
GLU A 534
HIS A 600
ASP A 601
None
1.47A 3aicD-5ot1A:
8.1
3aicD-5ot1A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
6 / 12 ARG A 501
ASP A 503
ASN A 506
GLU A 534
HIS A 600
ASP A 601
None
1.48A 3aicE-5ot1A:
8.1
3aicE-5ot1A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
6 / 12 ARG A 501
ASP A 503
ASN A 506
GLU A 534
HIS A 600
ASP A 601
None
1.47A 3aicF-5ot1A:
8.5
3aicF-5ot1A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
6 / 12 ARG A 501
ASP A 503
ASN A 506
GLU A 534
HIS A 600
ASP A 601
None
1.44A 3aicG-5ot1A:
8.0
3aicG-5ot1A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_1
(GLUCOSYLTRANSFERASE-
SI)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
6 / 12 ARG A 501
ASP A 503
ASN A 506
GLU A 534
HIS A 600
ASP A 601
None
1.45A 3aicH-5ot1A:
8.0
3aicH-5ot1A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 LEU A 485
ALA A 489
ILE A 486
VAL A 502
PHE A 514
None
0.97A 3b2rA-5ot1A:
undetectable
3b2rA-5ot1A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 11 LEU A 485
ALA A 489
ILE A 486
VAL A 502
PHE A 514
None
0.93A 3b2rB-5ot1A:
undetectable
3b2rB-5ot1A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B3P_B_H4BB760_1
(NITRIC-OXIDE
SYNTHASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 TRP A 465
GLU A 507
ARG A 501
TRP A 536
None
1.41A 3b3pA-5ot1A:
undetectable
3b3pB-5ot1A:
undetectable
3b3pA-5ot1A:
11.14
3b3pB-5ot1A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 GLU A 587
GLN A 231
VAL A 717
ARG A 709
None
1.14A 3b9lA-5ot1A:
undetectable
3b9lA-5ot1A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 LEU A 633
LEU A 632
MET A 695
LEU A 556
MET A 578
None
1.30A 3d90B-5ot1A:
undetectable
3d90B-5ot1A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
3 / 3 TYR A 386
ASP A 314
HIS A 344
None
0.83A 3e23A-5ot1A:
undetectable
3e23A-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
3 / 3 ARG A 501
ILE A 535
TRP A 536
None
1.12A 3e68A-5ot1A:
undetectable
3e68A-5ot1A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
3 / 3 ARG A 501
ILE A 535
TRP A 536
None
1.19A 3e6tB-5ot1A:
undetectable
3e6tB-5ot1A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 ARG A 501
ILE A 535
TRP A 536
GLU A 507
None
1.26A 3e7gA-5ot1A:
undetectable
3e7gB-5ot1A:
undetectable
3e7gA-5ot1A:
13.54
3e7gB-5ot1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 GLY A 611
ILE A 623
ASP A 608
LEU A 606
ARG A 604
None
1.08A 3iv6B-5ot1A:
undetectable
3iv6B-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 GLY A 611
ILE A 623
ASP A 608
LEU A 606
ARG A 604
None
1.03A 3iv6D-5ot1A:
undetectable
3iv6D-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_2
(CYTOCHROME P450 3A4)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 PHE A 514
ARG A 501
ILE A 416
THR A 385
None
1.27A 3nxuA-5ot1A:
undetectable
3nxuA-5ot1A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 PHE A 707
MET A 705
ILE A 761
VAL A 715
None
1.00A 3p6hA-5ot1A:
undetectable
3p6hA-5ot1A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_3
(PROTEASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
3 / 3 ASP A 498
THR A 639
PRO A 640
None
0.65A 3tkgD-5ot1A:
undetectable
3tkgD-5ot1A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 TRP A 492
VAL A 415
LEU A 405
ILE A 374
None
0.83A 3u5kA-5ot1A:
undetectable
3u5kA-5ot1A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 TRP A 492
VAL A 415
LEU A 405
ILE A 374
None
0.84A 3u5kC-5ot1A:
undetectable
3u5kC-5ot1A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 TRP A 492
VAL A 415
LEU A 405
ILE A 374
None
0.87A 3u5kD-5ot1A:
undetectable
3u5kD-5ot1A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 PHE A 419
VAL A 508
PHE A 514
VAL A 502
HIS A 423
None
1.12A 3u9fJ-5ot1A:
undetectable
3u9fK-5ot1A:
undetectable
3u9fJ-5ot1A:
undetectable
3u9fK-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A84_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 ILE A 368
VAL A 641
ASN A 553
SER A 550
LEU A 285
None
1.08A 4a84A-5ot1A:
undetectable
4a84A-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 ARG A 501
ILE A 535
TRP A 536
GLU A 507
None
1.27A 4cx7A-5ot1A:
undetectable
4cx7B-5ot1A:
undetectable
4cx7A-5ot1A:
13.54
4cx7B-5ot1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 GLU A 507
ARG A 501
ILE A 535
TRP A 536
None
1.31A 4cx7A-5ot1A:
undetectable
4cx7B-5ot1A:
undetectable
4cx7A-5ot1A:
13.54
4cx7B-5ot1A:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 LEU A 401
ILE A 371
LEU A 361
ALA A 408
LEU A 405
None
1.34A 4m11A-5ot1A:
undetectable
4m11A-5ot1A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 TYR A 564
VAL A 754
ALA A 726
SER A 721
GLY A 703
None
1.26A 4mm4A-5ot1A:
undetectable
4mm4A-5ot1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 TYR A 564
VAL A 754
ALA A 726
SER A 721
GLY A 703
None
1.26A 4mm4B-5ot1A:
undetectable
4mm4B-5ot1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 11 TYR A 564
VAL A 754
ALA A 726
SER A 721
GLY A 703
None
1.26A 4mm9A-5ot1A:
undetectable
4mm9A-5ot1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 HIS A 600
SER A 550
PHE A 594
ASP A 418
None
1.14A 4odjA-5ot1A:
undetectable
4odjA-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCH_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 8 TRP A 465
GLU A 507
ARG A 501
TRP A 536
None
1.42A 4uchA-5ot1A:
undetectable
4uchB-5ot1A:
undetectable
4uchA-5ot1A:
11.37
4uchB-5ot1A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 HIS A 344
CYH A 343
GLY A 378
HIS A 381
None
0.67A 5a5zC-5ot1A:
undetectable
5a5zC-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_1
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 ARG A 501
ASP A 503
GLU A 534
HIS A 600
ASP A 601
None
0.42A 5csyB-5ot1A:
19.6
5csyB-5ot1A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 6 PHE A 417
SER A 289
VAL A 288
ASP A 549
None
1.30A 5hesA-5ot1A:
undetectable
5hesA-5ot1A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
3 / 3 THR A 602
SER A 599
ASP A 503
None
0.71A 5kvaB-5ot1A:
undetectable
5kvaB-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 10 SER A 197
GLY A 593
ALA A 591
ASP A 200
SER A 693
None
1.40A 5l66K-5ot1A:
undetectable
5l66L-5ot1A:
undetectable
5l66K-5ot1A:
19.89
5l66L-5ot1A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 10 SER A 197
GLY A 593
ALA A 591
ASP A 200
SER A 693
None
1.40A 5l66Y-5ot1A:
undetectable
5l66Z-5ot1A:
undetectable
5l66Y-5ot1A:
19.89
5l66Z-5ot1A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 THR A 367
THR A 639
VAL A 532
TYR A 530
None
1.05A 5ov9A-5ot1A:
undetectable
5ov9A-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 7 THR A 602
LEU A 629
VAL A 673
GLN A 624
GLU A 621
None
1.38A 5tudA-5ot1A:
undetectable
5tudA-5ot1A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YN6_A_SAMA401_0
(NSP16 PROTEIN)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 GLY A 427
GLY A 457
ASN A 428
LEU A 376
ASP A 387
None
1.39A 5yn6A-5ot1A:
undetectable
5yn6A-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 5 HIS A 344
SER A 379
GLY A 378
TYR A 386
None
1.28A 5yodB-5ot1A:
undetectable
5yodB-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 5 HIS A 344
SER A 379
GLY A 378
TYR A 386
None
1.28A 5yodD-5ot1A:
undetectable
5yodD-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 5 ILE A 371
PHE A 404
ARG A 414
THR A 367
None
1.19A 5z84N-5ot1A:
undetectable
5z84W-5ot1A:
undetectable
5z84N-5ot1A:
undetectable
5z84W-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA610_0
(ALPHA-AMYLASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 12 TYR A 383
HIS A 423
ASP A 503
HIS A 600
ASP A 601
None
0.57A 6ag0A-5ot1A:
22.3
6ag0A-5ot1A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 7 ARG A 501
TRP A 536
TRP A 465
GLU A 507
None
1.47A 6auuA-5ot1A:
undetectable
6auuB-5ot1A:
undetectable
6auuA-5ot1A:
12.50
6auuB-5ot1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
4 / 6 VAL A 420
ASN A 506
PRO A 505
GLU A 507
None
1.21A 6h7uA-5ot1A:
undetectable
6h7uA-5ot1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis)
5 / 8 GLY A 487
LEU A 490
ALA A 521
LYS A 520
GLU A 517
None
1.22A 6mdqA-5ot1A:
undetectable
6mdqA-5ot1A:
19.78