SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ot4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		5 / 12 ILE A 505
ALA A 488
LEU A 460
ILE A 475
LEU A 467
 None
 1.15A 1ddsB-5ot4A:
undetectable		 1ddsB-5ot4A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		5 / 9 LYS A 500
ALA A 502
LYS A 471
LEU A 467
GLU A 474
 None
 1.46A 1sn0A-5ot4A:
undetectable
1sn0C-5ot4A:
undetectable		 1sn0A-5ot4A:
19.47
1sn0C-5ot4A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		4 / 8 PRO A  48
SER A  49
VAL A 181
GLY A 180
 None
 0.91A 2qd3A-5ot4A:
undetectable		 2qd3A-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		4 / 8 PRO A  48
SER A  49
VAL A 181
GLY A 180
 None
 0.96A 2qd5A-5ot4A:
undetectable		 2qd5A-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		4 / 6 LEU A 128
THR A 125
LEU A 202
ASP A 196
 None
 1.04A 2wm3A-5ot4A:
undetectable		 2wm3A-5ot4A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		5 / 12 ASP A  41
HIS A 108
GLY A 160
SER A 178
GLY A 151
 None
 1.34A 2y6rC-5ot4A:
undetectable		 2y6rC-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		5 / 10 ILE A 574
ALA A 550
GLN A 549
LEU A 551
ILE A 537
 None
 1.05A 3falC-5ot4A:
undetectable		 3falC-5ot4A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		5 / 11 ASP A  41
HIS A 108
GLY A 160
SER A 178
GLY A 151
 None
 1.27A 3v3oC-5ot4A:
undetectable		 3v3oC-5ot4A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		3 / 3 LEU A 725
MET A 719
ASP A 712
 None
 0.90A 3v5wA-5ot4A:
2.1		 3v5wA-5ot4A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		4 / 4 LEU A 417
GLY A 418
MET A 379
PHE A 410
 None
 1.41A 3vaqB-5ot4A:
undetectable		 3vaqB-5ot4A:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		4 / 6 GLY A 293
ASN A 296
ASN A 284
GLU A 287
 None
 0.96A 3zqtA-5ot4A:
undetectable		 3zqtA-5ot4A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		5 / 12 ILE A 505
ALA A 488
LEU A 460
ILE A 475
LEU A 467
 None
 1.12A 4gh8A-5ot4A:
undetectable		 4gh8A-5ot4A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		4 / 7 ASN A 523
ALA A 524
VAL A 529
ARG A 528
 None
 1.03A 4ijiH-5ot4A:
undetectable		 4ijiH-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		3 / 3 ASP A 429
LYS A 375
LEU A 371
 None
 1.07A 4ptjA-5ot4A:
undetectable		 4ptjA-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		5 / 11 LEU A  40
GLY A 119
LEU A 120
LEU A  36
ALA A  23
 None
 1.20A 4wnuA-5ot4A:
undetectable		 4wnuA-5ot4A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		3 / 3 GLU A 443
TRP A 436
ASN A 385
 None
 1.04A 5dv4A-5ot4A:
undetectable		 5dv4A-5ot4A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		3 / 3 GLU A 622
HIS A 618
VAL A 652
 None
 0.76A 5trqB-5ot4A:
undetectable		 5trqB-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		5 / 10 ALA A 743
LEU A 791
ASP A 841
VAL A 787
GLY A 785
 None
 1.31A 5zbdA-5ot4A:
undetectable		 5zbdA-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_B_TRPB501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		5 / 10 ALA A 743
LEU A 791
ASP A 841
VAL A 787
GLY A 785
 None
 1.30A 5zbdB-5ot4A:
undetectable		 5zbdB-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		5 / 12 ILE A 571
LEU A 592
PHE A 586
SER A 578
MET A 609
 None
 1.12A 6b52A-5ot4A:
undetectable		 6b52A-5ot4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		3 / 3 LEU A 711
GLN A 708
LYS A 807
 None
 0.90A 6exiB-5ot4A:
undetectable		 6exiB-5ot4A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 5ot4 INTERAPTIN
(Legionella
pneumophila) 		3 / 3 LEU A 711
GLN A 708
LYS A 807
 None
 0.90A 6exiA-5ot4A:
undetectable		 6exiA-5ot4A:
19.77