SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ou3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 ASN A 173
GLY A 196
CYH A 201
THR A 203
GLY A 285
 AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
AUN  A 401 ( 3.2A)
 0.58A 1jr1A-5ou3A:
48.5		 1jr1A-5ou3A:
43.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 11 ASP A 143
ASN A 173
GLY A 196
CYH A 201
THR A 203
 AUN  A 401 (-3.5A)
AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
 0.86A 1jr1A-5ou3A:
48.5		 1jr1A-5ou3A:
43.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 ASN A 173
GLY A 196
THR A 203
GLY A 285
 AUN  A 401 ( 3.1A)
None
None
AUN  A 401 ( 3.2A)
 0.46A 1jr1B-5ou3A:
48.4		 1jr1B-5ou3A:
43.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU A 237
PHE A 361
ALA A 248
ALA A 246
LEU A  65
 None
 1.40A 1kt5A-5ou3A:
undetectable		 1kt5A-5ou3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 ASN A 173
GLY A 196
CYH A 201
GLY A 285
 AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
AUN  A 401 ( 3.2A)
 0.34A 1me7A-5ou3A:
47.0		 1me7A-5ou3A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 TYR A 281
VAL A  73
SER A  68
GLY A 198
ILE A 200
 IMP  A 400 (-4.6A)
None
IMP  A 400 (-2.8A)
IMP  A 400 (-3.5A)
None
 1.33A 2dcfA-5ou3A:
undetectable		 2dcfA-5ou3A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU A  65
GLY A  87
LEU A 256
ALA A  85
GLY A 340
 None
 1.06A 2vmyB-5ou3A:
2.0		 2vmyB-5ou3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 TYR A 281
VAL A  73
SER A  68
GLY A 198
ILE A 200
 IMP  A 400 (-4.6A)
None
IMP  A 400 (-2.8A)
IMP  A 400 (-3.5A)
None
 1.39A 3a65A-5ou3A:
undetectable		 3a65A-5ou3A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 4 SER A 199
TYR A 281
GLY A 235
PRO A 197
 IMP  A 400 (-2.6A)
IMP  A 400 (-4.6A)
IMP  A 400 (-3.5A)
None
 1.47A 4e3aA-5ou3A:
1.9		 4e3aA-5ou3A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_2
(SUGAR KINASE PROTEIN)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 4 SER A 199
TYR A 281
GLY A 236
PRO A 197
 IMP  A 400 (-2.6A)
IMP  A 400 (-4.6A)
IMP  A 400 (-3.6A)
None
 1.31A 4e3aA-5ou3A:
1.9		 4e3aA-5ou3A:
13.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 8 ASN A 173
CYH A 201
THR A 203
MET A 284
GLY A 285
 AUN  A 401 ( 3.1A)
IMP  A 400 (-3.2A)
None
None
AUN  A 401 ( 3.2A)
 0.24A 4fo4A-5ou3A:
53.0		 4fo4A-5ou3A:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 8 ASP A 143
CYH A 201
THR A 203
MET A 284
GLY A 285
 AUN  A 401 (-3.5A)
IMP  A 400 (-3.2A)
None
None
AUN  A 401 ( 3.2A)
 0.77A 4fo4A-5ou3A:
53.0		 4fo4A-5ou3A:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		6 / 8 ASN A 173
GLY A 196
CYH A 201
THR A 203
MET A 284
GLY A 285
 AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
None
AUN  A 401 ( 3.2A)
 0.32A 4fo4B-5ou3A:
51.9		 4fo4B-5ou3A:
51.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		6 / 9 ASP A 143
ASN A 173
GLY A 196
CYH A 201
THR A 203
ASP A 234
 AUN  A 401 (-3.5A)
AUN  A 401 ( 3.1A)
None
IMP  A 400 (-3.2A)
None
IMP  A 400 (-2.6A)
 0.42A 4fxsA-5ou3A:
52.5		 4fxsA-5ou3A:
48.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 LEU A 153
HIS A 146
ALA A 147
ALA A 188
 None
AUN  A 401 (-4.4A)
None
None
 0.82A 4g77A-5ou3A:
undetectable		 4g77A-5ou3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 5 GLY A 194
ALA A 175
GLY A 196
PRO A 197
 None
 0.96A 4u9uA-5ou3A:
undetectable		 4u9uA-5ou3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 5 GLY A 194
ALA A 175
GLY A 196
PRO A 197
 None
 0.98A 4u9uB-5ou3A:
undetectable		 4u9uB-5ou3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 ARG A  60
THR A 352
ASP A  50
 None
 0.86A 5g5gA-5ou3A:
undetectable
5g5gB-5ou3A:
undetectable		 5g5gA-5ou3A:
undetectable
5g5gB-5ou3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 GLY A 283
GLY A 285
GLY A 268
ASN A  94
ARG A 282
 IMP  A 400 (-3.3A)
AUN  A 401 ( 3.2A)
None
None
None
 1.11A 6gngB-5ou3A:
undetectable		 6gngB-5ou3A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 LEU A 113
VAL A 119
MET A  82
GLY A  86
 None
 1.06A 6hd4B-5ou3A:
undetectable		 6hd4B-5ou3A:
16.87