SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ouo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5ouo PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		5 / 12 VAL A 931
LEU A 848
PHE A 927
PHE A 941
MET A1026
 None
 1.36A 1fdsA-5ouoA:
undetectable		 1fdsA-5ouoA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 5ouo PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 4 HIS A1061
ALA A 993
PHE A1058
GLY A 991
 None
 1.20A 1mj2B-5ouoA:
undetectable		 1mj2B-5ouoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))		 5ouo PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 4 HIS A1061
ALA A 993
PHE A1058
GLY A 991
 None
 1.12A 1mj2D-5ouoA:
undetectable		 1mj2D-5ouoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 5ouo PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 4 HIS A1061
ALA A 993
PHE A1058
GLY A 991
 None
 1.17A 1mjoB-5ouoA:
undetectable		 1mjoB-5ouoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 5ouo PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 4 HIS A1061
ALA A 993
PHE A1058
GLY A 991
 None
 1.13A 1mjoA-5ouoA:
undetectable		 1mjoA-5ouoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 5ouo PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 4 HIS A1061
ALA A 993
PHE A1058
GLY A 991
 None
 1.18A 1mjoD-5ouoA:
undetectable		 1mjoD-5ouoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 5ouo PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		5 / 11 GLY A 933
ASP A 936
ASP A 939
THR A 958
PRO A 957
 None
 0.89A 1ohrA-5ouoA:
undetectable		 1ohrA-5ouoA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_2
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5ouo PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		5 / 11 LEU A 987
VAL A 931
GLY A 937
ARG A1060
HIS A 990
 None
None
None
CL  A1103 (-3.6A)
None
 1.33A 1y4lB-5ouoA:
undetectable		 1y4lB-5ouoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5ouo PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 5 GLY A 933
HIS A 990
ASP A1001
ASP A 936
 None
 1.15A 2oxtB-5ouoA:
undetectable		 2oxtB-5ouoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 5ouo PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 8 TYR A 975
LEU A 816
LEU A 981
THR A1071
 None
 1.17A 5hs6A-5ouoA:
undetectable		 5hs6A-5ouoA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5ouo PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 7 THR A 958
ARG A1060
HIS A1023
ASP A 939
 None
CL  A1103 (-3.6A)
None
None
 0.92A 6mn4E-5ouoA:
undetectable		 6mn4E-5ouoA:
undetectable