SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 5 GLY A 796
LEU A 797
THR A 798
VAL A 476
 None
 1.10A 1ekjF-5oupA:
undetectable
1ekjG-5oupA:
undetectable		 1ekjF-5oupA:
undetectable
1ekjG-5oupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 7 ASP A 474
SER A 565
SER A 563
ASN A 562
 None
 1.25A 1ig3A-5oupA:
undetectable
1ig3B-5oupA:
undetectable		 1ig3A-5oupA:
14.18
1ig3B-5oupA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		5 / 9 PHE A 784
VAL A 608
LEU A 497
PHE A 657
LEU A 775
 None
 1.41A 1wrkA-5oupA:
undetectable
1wrkB-5oupA:
undetectable		 1wrkA-5oupA:
19.75
1wrkB-5oupA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		3 / 3 TRP A 754
THR A 734
TYR A 677
 None
 0.89A 2a3aA-5oupA:
undetectable		 2a3aA-5oupA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		3 / 3 TRP A 754
THR A 734
TYR A 677
 None
 0.80A 2a3aB-5oupA:
undetectable		 2a3aB-5oupA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		3 / 3 TRP A 754
THR A 734
TYR A 677
 None
 0.89A 2a3bA-5oupA:
undetectable		 2a3bA-5oupA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		3 / 3 TYR A 677
VAL A 745
THR A 676
 None
 0.88A 2ygnA-5oupA:
undetectable		 2ygnA-5oupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFL_A_5CHA693_1
(LACTOTRANSFERRIN)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 4 THR A 609
VAL A 616
GLY A 662
THR A 663
 None
 1.04A 3cflA-5oupA:
undetectable		 3cflA-5oupA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 8 GLY A 478
ILE A 737
PHE A 670
PHE A 767
 None
 0.92A 3ko0B-5oupA:
undetectable
3ko0J-5oupA:
undetectable		 3ko0B-5oupA:
14.85
3ko0J-5oupA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_B_SAMB6735_0
(N-LYSINE
METHYLTRANSFERASE
SETD6
TRANSCRIPTION FACTOR
P65)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		5 / 11 VAL A 496
ALA A 471
TYR A 473
ALA A 596
PHE A 499
 None
 1.44A 3qxyB-5oupA:
undetectable
3qxyQ-5oupA:
undetectable		 3qxyB-5oupA:
undetectable
3qxyQ-5oupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		3 / 3 GLN A 641
THR A 647
ASN A 642
 None
 0.70A 3v4tE-5oupA:
undetectable		 3v4tE-5oupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVA_A_T3A1314_1
(THIOMORPHOLINE-CARBO
XYLATE DEHYDROGENASE)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		5 / 12 GLY A 672
VAL A 765
PHE A 670
SER A 531
ARG A 529
 None
 1.32A 4bvaA-5oupA:
undetectable		 4bvaA-5oupA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 5 GLY A 738
VAL A 758
PRO A 762
TYR A 468
 None
 1.05A 4grkA-5oupA:
undetectable		 4grkA-5oupA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		5 / 9 LEU A 619
VAL A 616
GLY A 615
VAL A 496
VAL A 608
 None
 1.40A 5cp4A-5oupA:
undetectable		 5cp4A-5oupA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 7 GLN A 554
GLY A 472
GLY A 470
VAL A 496
 None
 0.65A 6ekzA-5oupA:
undetectable		 6ekzA-5oupA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 5oup PERFORIN-LIKE
PROTEIN 1
(Toxoplasma
gondii) 		4 / 7 GLN A 618
GLY A 615
VAL A 496
LYS A 780
 None
 0.82A 6hu9S-5oupA:
undetectable
6hu9q-5oupA:
undetectable		 6hu9S-5oupA:
undetectable
6hu9q-5oupA:
undetectable