SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ovk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 161
ILE A  35
GLY A 147
ALA A 166
GLY A 192
 None
NDP  A 301 ( 4.5A)
None
None
None
 1.09A 1kiaA-5ovkA:
5.7		 1kiaA-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 161
ILE A  35
GLY A 147
ALA A 166
GLY A 192
 None
NDP  A 301 ( 4.5A)
None
None
None
 1.10A 1kiaB-5ovkA:
5.9		 1kiaB-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 161
ILE A  35
GLY A 147
ALA A 166
GLY A 192
 None
NDP  A 301 ( 4.5A)
None
None
None
 1.10A 1kiaC-5ovkA:
6.1		 1kiaC-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 161
ILE A  35
GLY A 147
ALA A 166
GLY A 192
 None
NDP  A 301 ( 4.5A)
None
None
None
 1.09A 1nbhB-5ovkA:
6.2		 1nbhB-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 161
ILE A  35
GLY A 147
ALA A 166
GLY A 192
 None
NDP  A 301 ( 4.5A)
None
None
None
 1.06A 1nbiA-5ovkA:
6.4		 1nbiA-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 161
ILE A  35
GLY A 147
ALA A 166
GLY A 192
 None
NDP  A 301 ( 4.5A)
None
None
None
 1.07A 1nbiB-5ovkA:
6.5		 1nbiB-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY A 250
ILE A 214
TRP A 153
VAL A 149
 None
 1.21A 1rs7A-5ovkA:
undetectable		 1rs7A-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 123
ALA A 124
ILE A 146
GLY A  98
ILE A  99
 None
None
None
NDP  A 301 (-4.5A)
NDP  A 301 ( 4.9A)
 0.86A 2aquB-5ovkA:
undetectable		 2aquB-5ovkA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A  30
ARG A  55
ASP A  69
ASN A  96
ALA A  97
 NDP  A 301 (-3.3A)
NDP  A 301 (-3.3A)
NDP  A 301 (-3.4A)
NDP  A 301 ( 4.4A)
NDP  A 301 (-3.6A)
 1.00A 2bm9E-5ovkA:
4.5		 2bm9E-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		4 / 7 VAL A  76
SER A  73
ARG A 126
THR A 122
 None
 1.11A 2f78B-5ovkA:
undetectable		 2f78B-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 123
ALA A 124
ILE A 146
GLY A  98
ILE A  99
 None
None
None
NDP  A 301 (-4.5A)
NDP  A 301 ( 4.9A)
 0.89A 2fxeB-5ovkA:
undetectable		 2fxeB-5ovkA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 123
ALA A 124
ILE A 146
GLY A  98
ILE A  99
 None
None
None
NDP  A 301 (-4.5A)
NDP  A 301 ( 4.9A)
 0.88A 2nnpA-5ovkA:
undetectable		 2nnpA-5ovkA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLY A 123
ALA A 124
ILE A 146
GLY A  98
ILE A  99
 None
None
None
NDP  A 301 (-4.5A)
NDP  A 301 ( 4.9A)
 0.90A 3el4A-5ovkA:
undetectable		 3el4A-5ovkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLY A 123
ALA A 124
ILE A 146
GLY A  98
ILE A  99
 None
None
None
NDP  A 301 (-4.5A)
NDP  A 301 ( 4.9A)
 0.89A 3el9B-5ovkA:
undetectable		 3el9B-5ovkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ASN A  96
VAL A  94
ILE A  39
GLY A 227
ILE A 144
 NDP  A 301 ( 4.4A)
None
None
None
None
 1.00A 3lzvB-5ovkA:
undetectable		 3lzvB-5ovkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 123
ALA A 124
ILE A 146
GLY A  98
ILE A  99
 None
None
None
NDP  A 301 (-4.5A)
NDP  A 301 ( 4.9A)
 0.90A 3ndxB-5ovkA:
undetectable		 3ndxB-5ovkA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		4 / 5 SER A 148
ILE A  35
TYR A 161
GLY A 192
 None
NDP  A 301 ( 4.5A)
None
None
 0.96A 3uboB-5ovkA:
6.3		 3uboB-5ovkA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		4 / 5 TYR A 161
VAL A 116
SER A 100
GLY A  98
 None
None
None
NDP  A 301 (-4.5A)
 1.28A 3v4tA-5ovkA:
undetectable
3v4tD-5ovkA:
undetectable		 3v4tA-5ovkA:
undetectable
3v4tD-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY A 250
ILE A 214
TRP A 153
VAL A 149
 None
 1.24A 4d33A-5ovkA:
undetectable		 4d33A-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		4 / 5 GLY A 250
ILE A 214
TRP A 153
VAL A 149
 None
 1.25A 4d33B-5ovkA:
undetectable		 4d33B-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLN A  87
LEU A  43
GLU A  84
ILE A 144
ARG A 130
 None
 0.95A 4hytA-5ovkA:
3.4		 4hytA-5ovkA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLN A  87
LEU A  43
GLU A  84
ILE A 144
ARG A 130
 None
 0.96A 4hytC-5ovkA:
undetectable		 4hytC-5ovkA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ILE A 117
MET A 108
ARG A 112
 None
 0.87A 4lnwA-5ovkA:
undetectable		 4lnwA-5ovkA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ILE A 117
MET A 108
ARG A 112
 None
 0.87A 4lnxA-5ovkA:
undetectable		 4lnxA-5ovkA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLY A 123
ALA A 124
ILE A 146
GLY A  98
ILE A  99
 None
None
None
NDP  A 301 (-4.5A)
NDP  A 301 ( 4.9A)
 0.86A 4qgiA-5ovkA:
undetectable		 4qgiA-5ovkA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A  63
LEU A  27
VAL A  28
PHE A  64
 None
 1.26A 4uswA-5ovkA:
undetectable		 4uswA-5ovkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 9 LEU A 168
GLY A  98
ALA A  97
GLY A  36
ILE A  35
 None
NDP  A 301 (-4.5A)
NDP  A 301 (-3.6A)
None
NDP  A 301 ( 4.5A)
 1.05A 5kr0B-5ovkA:
undetectable		 5kr0B-5ovkA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5ovk 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE FABG
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A  50
LEU A  63
VAL A  28
GLY A  36
ILE A  39
 None
 0.96A 5vopA-5ovkA:
3.0		 5vopA-5ovkA:
undetectable