SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ovo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		3 / 3 TRP A 149
ARG A 176
THR A 150
 None
 0.99A 1df7A-5ovoA:
undetectable		 1df7A-5ovoA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5ovo NITROGEN REGULATORY
PROTEIN P-II 1
(Azospirillum
brasilense) 		5 / 9 VAL B  63
VAL B  16
LEU B  20
ILE B  91
ALA B   6
 ADP  B 201 (-4.0A)
None
None
None
None
 0.93A 1eqgA-5ovoB:
undetectable		 1eqgA-5ovoB:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5ovo NITROGEN REGULATORY
PROTEIN P-II 1
(Azospirillum
brasilense) 		5 / 11 VAL B  63
VAL B  16
LEU B  20
ILE B  91
ALA B   6
 ADP  B 201 (-4.0A)
None
None
None
None
 0.94A 1eqgB-5ovoB:
undetectable		 1eqgB-5ovoB:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5ovo NITROGEN REGULATORY
PROTEIN P-II 1
(Azospirillum
brasilense) 		5 / 12 VAL B  63
VAL B  16
LEU B  20
ILE B  91
ALA B   6
 ADP  B 201 (-4.0A)
None
None
None
None
 0.93A 1eqhA-5ovoB:
undetectable		 1eqhA-5ovoB:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5ovo NITROGEN REGULATORY
PROTEIN P-II 1
(Azospirillum
brasilense) 		5 / 12 VAL B  63
VAL B  16
LEU B  20
ILE B  91
ALA B   6
 ADP  B 201 (-4.0A)
None
None
None
None
 0.93A 1eqhB-5ovoB:
undetectable		 1eqhB-5ovoB:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		3 / 3 GLU A  63
THR A  62
LEU A 272
 None
 0.65A 1v8bC-5ovoA:
undetectable		 1v8bC-5ovoA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		5 / 12 GLY A  12
VAL A 284
SER A   5
LEU A  11
LEU A 288
 None
 1.22A 1ya4B-5ovoA:
undetectable		 1ya4B-5ovoA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2001_1
(SERUM ALBUMIN)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		4 / 8 ALA A  88
PHE A  87
ALA A  83
LEU A  68
 None
 0.92A 2bxmA-5ovoA:
undetectable		 2bxmA-5ovoA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		5 / 12 ALA A  13
GLY A 256
LEU A  11
SER A   8
LEU A 287
 None
 1.26A 3bxoA-5ovoA:
undetectable		 3bxoA-5ovoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		3 / 3 GLU A 231
HIS A  42
HIS A  44
 None
 0.82A 3co4A-5ovoA:
undetectable		 3co4A-5ovoA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		4 / 4 LEU A 287
PRO A 134
LEU A 137
ARG A   7
 None
 1.36A 3hcoB-5ovoA:
undetectable		 3hcoB-5ovoA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		5 / 11 GLY A  69
LEU A 133
SER A  65
LEU A 137
LEU A 287
 None
 1.36A 3ndvA-5ovoA:
undetectable
3ndvB-5ovoA:
undetectable		 3ndvA-5ovoA:
22.47
3ndvB-5ovoA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		5 / 11 LEU A 137
LEU A 287
GLY A  69
LEU A 133
SER A  65
 None
 1.40A 3ndvA-5ovoA:
undetectable
3ndvB-5ovoA:
undetectable		 3ndvA-5ovoA:
22.47
3ndvB-5ovoA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		5 / 11 GLY A  69
LEU A 133
SER A  65
LEU A 137
LEU A 287
 None
 1.39A 3ndvC-5ovoA:
undetectable
3ndvD-5ovoA:
undetectable		 3ndvC-5ovoA:
22.47
3ndvD-5ovoA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		5 / 11 LEU A 137
LEU A 287
GLY A  69
LEU A 133
SER A  65
 None
 1.37A 3ndvC-5ovoA:
undetectable
3ndvD-5ovoA:
undetectable		 3ndvC-5ovoA:
22.47
3ndvD-5ovoA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		4 / 8 ASP A  61
ASP A  60
GLY A  99
GLN A  57
 MG  A 302 ( 4.1A)
MG  A 302 ( 3.7A)
ADP  A 301 (-3.4A)
None
 0.97A 3s3mA-5ovoA:
undetectable		 3s3mA-5ovoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		4 / 5 LEU A  51
PRO A  95
VAL A  96
ASP A  21
 None
 1.08A 3ufnA-5ovoA:
undetectable
3ufnB-5ovoA:
undetectable		 3ufnA-5ovoA:
16.90
3ufnB-5ovoA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		4 / 6 SER A 163
ASP A 164
ILE A 213
THR A 150
 None
 0.97A 4acbC-5ovoA:
undetectable		 4acbC-5ovoA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		4 / 5 GLY A 125
TYR A 122
TYR A 212
GLU A 121
 ADP  A 301 ( 3.3A)
None
ADP  A 301 (-3.4A)
None
 1.04A 4ae1B-5ovoA:
undetectable		 4ae1B-5ovoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		3 / 3 ASN A 126
ASP A  61
ASP A  97
 ADP  A 301 (-4.5A)
MG  A 302 ( 4.1A)
None
 0.80A 4obwD-5ovoA:
undetectable		 4obwD-5ovoA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		4 / 7 ILE A 156
HIS A  67
LEU A  68
ALA A  71
 None
 0.87A 5hrqE-5ovoA:
undetectable
5hrqF-5ovoA:
undetectable
5hrqJ-5ovoA:
undetectable		 5hrqE-5ovoA:
7.87
5hrqF-5ovoA:
10.99
5hrqJ-5ovoA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KSG_B_NIZB809_1
(CATALASE-PEROXIDASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		5 / 9 ARG A 206
GLY A 207
GLN A 218
LEU A 208
THR A 219
 None
 1.12A 5ksgB-5ovoA:
0.8		 5ksgB-5ovoA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KT8_B_NIZB809_1
(CATALASE-PEROXIDASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		5 / 9 ARG A 206
GLY A 207
GLN A 218
LEU A 208
THR A 219
 None
 1.11A 5kt8B-5ovoA:
0.9		 5kt8B-5ovoA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		3 / 3 THR A 157
HIS A 123
ASN A 160
 None
 0.93A 5n4tA-5ovoA:
undetectable		 5n4tA-5ovoA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_B_NIZB805_1
(CATALASE-PEROXIDASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		5 / 9 ARG A 206
GLY A 207
GLN A 218
LEU A 208
THR A 219
 None
 1.12A 5syiB-5ovoA:
0.6		 5syiB-5ovoA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CFQ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		5 / 9 ARG A 206
GLY A 207
GLN A 218
LEU A 208
THR A 219
 None
 1.10A 6cfqB-5ovoA:
0.8		 6cfqB-5ovoA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
(Azospirillum
brasilense) 		4 / 7 GLY A 127
ALA A 128
VAL A 135
LEU A  68
 ADP  A 301 (-3.0A)
None
None
None
 0.77A 6dwnB-5ovoA:
undetectable		 6dwnB-5ovoA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
NITROGEN REGULATORY
PROTEIN P-II 1
(Azospirillum
brasilense;
Azospirillum
brasilense) 		5 / 12 LEU B  20
ILE B  25
GLY B  24
ILE A 110
ILE B  77
 None
 0.85A 6emuB-5ovoB:
undetectable		 6emuB-5ovoB:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 5ovo ADP-RIBOSYL-(DINITRO
GEN REDUCTASE)
HYDROLASE
NITROGEN REGULATORY
PROTEIN P-II 1
(Azospirillum
brasilense;
Azospirillum
brasilense) 		5 / 12 LEU B  20
ILE B  25
GLY B  24
ILE A 110
ILE B  77
 None
 0.83A 6emuC-5ovoB:
undetectable		 6emuC-5ovoB:
21.32