SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5owx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 5owx GENOME POLYPROTEIN
(Foot-and-mouth
disease
virus) 		3 / 3 VAL 2 160
VAL 2 107
TRP 2 105
 None
 0.90A 1av2A-5owx2:
undetectable
1av2B-5owx2:
undetectable		 1av2A-5owx2:
8.05
1av2B-5owx2:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5owx GENOME POLYPROTEIN
(Foot-and-mouth
disease
virus) 		3 / 3 TYR 1  72
GLU 2 128
TYR 1 130
 None
 0.96A 3ug8A-5owx1:
undetectable		 3ug8A-5owx1:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWL_A_ASCA303_0
(DIOSCORIN 5)		 5owx GENOME POLYPROTEIN
GENOME POLYPROTEIN
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		5 / 10 ASP 1 131
VAL 2 126
VAL 2 180
PHE 2 132
ALA 2 131
 None
 1.45A 4twlA-5owx1:
undetectable		 4twlA-5owx1:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 5owx GENOME POLYPROTEIN
(Foot-and-mouth
disease
virus) 		4 / 4 VAL 2 109
ALA 2 156
ASN 2 153
GLN 2 146
 None
 1.36A 4zgfA-5owx2:
undetectable		 4zgfA-5owx2:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 5owx GENOME POLYPROTEIN
(Foot-and-mouth
disease
virus) 		4 / 6 VAL 2 109
ALA 2 156
GLN 2 146
VAL 2 123
 None
 0.93A 5i8fA-5owx2:
undetectable		 5i8fA-5owx2:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5owx GENOME POLYPROTEIN
(Foot-and-mouth
disease
virus) 		5 / 12 GLY 1 132
ALA 2 131
VAL 1 129
TYR 1 130
LYS 2  80
 None
 1.23A 5kbwB-5owx1:
undetectable		 5kbwB-5owx1:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5owx GENOME POLYPROTEIN
(Foot-and-mouth
disease
virus) 		3 / 3 ILE 2 158
THR 2 159
PRO 2 144
 None
 0.57A 6ncsA-5owx2:
undetectable		 6ncsA-5owx2:
18.57