SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5oyj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)		 5oyj VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 GLU C 540
VAL C 542
ILE C 543
ILE C 497
ILE C 519
 None
 1.00A 1fapA-5oyjC:
undetectable		 1fapA-5oyjC:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 5oyj VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		5 / 12 GLU C 540
VAL C 542
ILE C 543
ILE C 497
ILE C 519
 None
 0.95A 1fklA-5oyjC:
undetectable		 1fklA-5oyjC:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 5oyj VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		3 / 3 VAL C 499
VAL C 518
TRP C 458
 None
 0.97A 1w5uA-5oyjC:
undetectable
1w5uB-5oyjC:
undetectable		 1w5uA-5oyjC:
undetectable
1w5uB-5oyjC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 5oyj DARPIN D4B
(synthetic
construct) 		4 / 7 VAL A 106
VAL A 139
ASN A 135
GLY A 136
 None
 1.03A 3kmoB-5oyjA:
undetectable		 3kmoB-5oyjA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5oyj VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		3 / 3 ARG C 541
ILE C 456
TRP C 458
 None
 1.12A 3nw2A-5oyjC:
undetectable		 3nw2A-5oyjC:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 5oyj DARPIN D4B
(synthetic
construct) 		5 / 12 VAL A  30
LEU A  18
LEU A  51
ILE A  62
ALA A  71
 None
 0.98A 4p65B-5oyjA:
undetectable
4p65D-5oyjA:
undetectable
4p65I-5oyjA:
undetectable
4p65J-5oyjA:
undetectable		 4p65B-5oyjA:
undetectable
4p65D-5oyjA:
undetectable
4p65I-5oyjA:
undetectable
4p65J-5oyjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 5oyj DARPIN D4B
(synthetic
construct) 		5 / 12 LEU A  51
VAL A  30
LEU A  18
ILE A  62
ALA A  71
 None
 1.05A 4p65F-5oyjA:
undetectable
4p65H-5oyjA:
undetectable
4p65K-5oyjA:
undetectable
4p65L-5oyjA:
undetectable		 4p65F-5oyjA:
undetectable
4p65H-5oyjA:
undetectable
4p65K-5oyjA:
undetectable
4p65L-5oyjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5oyj VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 6 GLU C 463
PHE C 545
TYR C 435
HIS C 546
 ACT  C 611 (-4.4A)
None
None
None
 1.06A 4uciA-5oyjC:
undetectable		 4uciA-5oyjC:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 5oyj VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens) 		4 / 7 GLU C 463
PHE C 545
TYR C 435
HIS C 546
 ACT  C 611 (-4.4A)
None
None
None
 1.19A 4uciB-5oyjC:
undetectable		 4uciB-5oyjC:
11.08