SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5p60'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BU5_B_RBFB302_1
(PROTEIN (FLAVODOXIN))		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 8 THR A 135
ASN A 134
ASP A  81
GLY A 127
 None
 1.02A 1bu5B-5p60A:
undetectable		 1bu5B-5p60A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 12 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.22A 1hvyA-5p60A:
undetectable		 1hvyA-5p60A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 12 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.22A 1hvyB-5p60A:
undetectable		 1hvyB-5p60A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 11 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.17A 1hvyC-5p60A:
undetectable		 1hvyC-5p60A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_A_D16A315_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 9 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.16A 1i00A-5p60A:
undetectable		 1i00A-5p60A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I00_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 9 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.16A 1i00B-5p60A:
undetectable		 1i00B-5p60A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA8_0
(GRAMICIDIN B)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 4 GLY A 326
VAL A 316
TRP A 197
TRP A 195
 None
 1.27A 1jo3A-5p60A:
undetectable		 1jo3A-5p60A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB8_0
(GRAMICIDIN B)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 4 GLY A 326
VAL A 316
TRP A 197
TRP A 195
 None
 1.27A 1jo3B-5p60A:
undetectable		 1jo3B-5p60A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 8 SER A 199
ILE A 273
PHE A 262
VAL A 231
 None
 0.93A 1kb9A-5p60A:
undetectable
1kb9C-5p60A:
undetectable
1kb9D-5p60A:
undetectable
1kb9E-5p60A:
undetectable		 1kb9A-5p60A:
23.87
1kb9C-5p60A:
21.80
1kb9D-5p60A:
20.96
1kb9E-5p60A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA8_0
(GRAMICIDIN A)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 4 GLY A 326
VAL A 316
TRP A 197
TRP A 195
 None
 1.09A 1nt5A-5p60A:
undetectable		 1nt5A-5p60A:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB8_0
(GRAMICIDIN A)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 4 GLY A 326
VAL A 316
TRP A 197
TRP A 195
 None
 1.09A 1nt5B-5p60A:
undetectable		 1nt5B-5p60A:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 8 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.14A 1rtsA-5p60A:
undetectable		 1rtsA-5p60A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 7 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.18A 1rtsB-5p60A:
undetectable		 1rtsB-5p60A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 5 LEU A 161
ASP A 307
GLY A  37
ALA A 159
 None
 0.88A 2aohA-5p60A:
7.3		 2aohA-5p60A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 7 SER A 113
SER A  83
SER A 115
GLN A  56
 None
 1.11A 2cmlA-5p60A:
undetectable		 2cmlA-5p60A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 8 SER A 113
SER A  83
SER A 115
GLN A  56
 None
 1.05A 2cmlD-5p60A:
undetectable		 2cmlD-5p60A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 4 SER A  38
TRP A  42
ASP A  11
ILE A  10
 None
 1.30A 2oxtD-5p60A:
undetectable		 2oxtD-5p60A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 7 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.11A 2tsrA-5p60A:
undetectable		 2tsrA-5p60A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 10 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.07A 2tsrC-5p60A:
undetectable		 2tsrC-5p60A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 9 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.15A 2tsrD-5p60A:
undetectable		 2tsrD-5p60A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		6 / 12 ASP A  35
GLY A  37
SER A  38
TYR A  79
ASP A 219
GLY A 221
 None
 0.38A 2v0zC-5p60A:
38.1		 2v0zC-5p60A:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 12 ASP A  35
GLY A  37
ASP A 219
GLY A 221
ILE A 302
 None
 0.59A 2v0zO-5p60A:
37.7		 2v0zO-5p60A:
28.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 12 TRP A 197
ALA A 218
LEU A 310
ALA A 313
GLY A 267
 None
 1.10A 2ve3A-5p60A:
undetectable		 2ve3A-5p60A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 10 THR A  48
PHE A 116
SER A  84
SER A  78
GLY A  87
 None
 1.50A 2x2iD-5p60A:
undetectable		 2x2iD-5p60A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 11 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
 None
 0.95A 2y7kA-5p60A:
undetectable		 2y7kA-5p60A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_B_SALB1304_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 10 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
 None
 1.02A 2y7kB-5p60A:
undetectable		 2y7kB-5p60A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 12 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
 None
 1.09A 2y7kC-5p60A:
undetectable		 2y7kC-5p60A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 12 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
 None
 1.12A 2y7kD-5p60A:
undetectable		 2y7kD-5p60A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 10 THR A 212
ILE A 214
GLY A 201
PHE A 262
PRO A 228
 None
 1.02A 2y7pA-5p60A:
undetectable		 2y7pA-5p60A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 12 GLY A 205
GLY A 275
ASP A 279
ALA A 234
TRP A 236
 None
 1.13A 3ou6A-5p60A:
undetectable		 3ou6A-5p60A:
20.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		10 / 10 ILE A  10
ASP A  11
ALA A  16
ILE A  77
TYR A  79
LEU A 125
THR A 135
ILE A 217
THR A 223
ILE A 300
 None
 0.31A 3prsA-5p60A:
58.1		 3prsA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 10 ILE A  77
TYR A  79
LEU A 125
THR A 135
ILE A 302
 None
 1.03A 3prsA-5p60A:
58.1		 3prsA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 10 ILE A  77
TYR A  79
THR A 135
ILE A 302
THR A 223
 None
 0.96A 3prsA-5p60A:
58.1		 3prsA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PRS_A_RITA1001_2
(ENDOTHIAPEPSIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		12 / 12 ASP A  15
ASP A  33
ASP A  35
GLY A  37
GLY A  80
ASP A  81
ASP A 119
PHE A 194
ASP A 219
THR A 222
TYR A 226
ILE A 304
 None
 0.46A 3prsA-5p60A:
58.1		 3prsA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		12 / 12 ILE A  10
ASP A  15
ASP A  33
ASP A  35
GLY A  80
PHE A 116
LEU A 125
PHE A 194
ILE A 217
THR A 222
TYR A 226
ILE A 304
 None
 0.24A 3pwwA-5p60A:
57.9		 3pwwA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		6 / 12 ILE A  10
ASP A  15
ASP A  33
GLY A  82
PHE A 116
LEU A 125
 None
 1.04A 3pwwA-5p60A:
57.9		 3pwwA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 12 ILE A 122
ILE A 217
THR A 222
TYR A 226
ILE A 304
 None
 1.03A 3pwwA-5p60A:
57.9		 3pwwA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		8 / 8 GLY A  37
SER A  38
ILE A  77
TYR A  79
ASP A  81
SER A  83
ASP A 219
THR A 223
 None
 0.45A 3pwwA-5p60A:
57.9		 3pwwA-5p60A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		7 / 12 ASP A  35
GLY A  37
GLY A  80
ASP A 219
THR A 222
TYR A 226
ILE A 304
 None
 0.42A 3q70A-5p60A:
10.3		 3q70A-5p60A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		7 / 12 ASP A  35
GLY A  37
ILE A 122
ASP A 219
THR A 222
TYR A 226
ILE A 304
 None
 1.05A 3q70A-5p60A:
10.3		 3q70A-5p60A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 6 SER A  38
ILE A  77
TYR A  79
ASP A 119
 None
 0.84A 3q70A-5p60A:
10.3		 3q70A-5p60A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 6 SER A  38
ILE A  77
TYR A  79
THR A 223
 None
 0.28A 3q70A-5p60A:
10.3		 3q70A-5p60A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 12 LEU A 310
ALA A 159
LEU A 325
ILE A 217
GLY A  37
 None
 1.09A 3q95A-5p60A:
undetectable		 3q95A-5p60A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 5 LEU A  99
GLY A   3
PHE A 171
PHE A 144
 None
 1.15A 3smtA-5p60A:
undetectable		 3smtA-5p60A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 6 GLY A 205
VAL A 272
SER A 261
THR A 263
 None
 0.76A 3tj7A-5p60A:
undetectable
3tj7B-5p60A:
undetectable		 3tj7A-5p60A:
18.15
3tj7B-5p60A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 6 GLY A 205
VAL A 272
SER A 261
THR A 263
 None
 0.77A 3tj7C-5p60A:
undetectable
3tj7D-5p60A:
undetectable		 3tj7C-5p60A:
18.15
3tj7D-5p60A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 6 VAL A 272
SER A 261
THR A 263
GLY A 205
 None
 0.74A 3tj7C-5p60A:
undetectable
3tj7D-5p60A:
undetectable		 3tj7C-5p60A:
18.15
3tj7D-5p60A:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		9 / 12 ASP A  35
GLY A  37
ILE A  77
GLY A  80
ASP A  81
ASP A 119
ASP A 219
TYR A 226
ILE A 304
 None
 0.86A 3tneA-5p60A:
36.7		 3tneA-5p60A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		9 / 12 ASP A  35
GLY A  37
ILE A  77
GLY A  80
ASP A  81
SER A  83
ASP A 219
TYR A 226
ILE A 304
 None
 0.43A 3tneA-5p60A:
36.7		 3tneA-5p60A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 6 SER A  38
TYR A  79
THR A 222
THR A 223
 None
 0.26A 3tneA-5p60A:
36.7		 3tneA-5p60A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		8 / 12 ASP A  35
GLY A  37
ILE A  77
GLY A  80
ASP A  81
ASP A 119
ASP A 219
ILE A 304
 None
 0.83A 3tneB-5p60A:
36.8		 3tneB-5p60A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		8 / 12 ASP A  35
GLY A  37
ILE A  77
GLY A  80
ASP A  81
SER A  83
ASP A 219
ILE A 304
 None
 0.37A 3tneB-5p60A:
36.8		 3tneB-5p60A:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 7 SER A  38
TYR A  79
THR A 222
THR A 223
TYR A 226
 None
 0.37A 3tneB-5p60A:
36.8		 3tneB-5p60A:
30.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 8 LEU A  41
VAL A  96
VAL A 101
LEU A  32
 None
 0.89A 3v81C-5p60A:
undetectable		 3v81C-5p60A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 5 SER A 108
GLY A  87
TRP A  42
ASP A  40
 None
 1.15A 3w9tB-5p60A:
undetectable		 3w9tB-5p60A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 5 SER A 108
GLY A  87
TRP A  42
ASP A  40
 None
 1.15A 3w9tC-5p60A:
undetectable		 3w9tC-5p60A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 5 SER A 108
GLY A  87
TRP A  42
ASP A  40
 None
 1.16A 3w9tD-5p60A:
0.0		 3w9tD-5p60A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 7 ASP A  35
GLY A 124
ILE A 122
THR A 220
 None
 0.73A 4acaC-5p60A:
undetectable		 4acaC-5p60A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		3 / 3 GLY A 265
SER A 199
TRP A 197
 None
 0.93A 4e7cD-5p60A:
undetectable		 4e7cD-5p60A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 12 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.17A 4eb4A-5p60A:
undetectable		 4eb4A-5p60A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 12 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.19A 4eb4B-5p60A:
undetectable		 4eb4B-5p60A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 9 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.11A 4eb4C-5p60A:
undetectable		 4eb4C-5p60A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 10 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.15A 4eb4D-5p60A:
undetectable		 4eb4D-5p60A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 7 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.16A 4iqqB-5p60A:
undetectable		 4iqqB-5p60A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 7 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.08A 4iqqC-5p60A:
undetectable		 4iqqC-5p60A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 5 THR A  66
THR A  93
ASP A  92
TYR A  59
 None
 1.20A 4oltA-5p60A:
undetectable		 4oltA-5p60A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 8 LEU A  41
VAL A  96
VAL A 101
LEU A  32
 None
 0.90A 4pwdC-5p60A:
undetectable		 4pwdC-5p60A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 8 LEU A  41
VAL A  96
VAL A 101
LEU A  32
 None
 0.80A 4q0bA-5p60A:
undetectable		 4q0bA-5p60A:
18.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		6 / 6 LEU A  13
ASP A  15
LEU A 224
PHE A 280
ILE A 283
PHE A 291
 None
 0.09A 4y4dA-5p60A:
58.7		 4y4dA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		9 / 9 ASP A  33
ASP A  35
TYR A  79
ASP A  81
SER A  83
SER A 115
PHE A 116
ASP A 119
LEU A 125
 None
 0.28A 4y4jA-5p60A:
58.6		 4y4jA-5p60A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4Y4J_A_LNRA412_1
(ENDOTHIAPEPSIN)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		6 / 9 ASP A  35
TYR A  79
SER A  83
SER A 113
PHE A 116
LEU A 125
 None
 1.45A 4y4jA-5p60A:
58.6		 4y4jA-5p60A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 6 PHE A  34
SER A  38
LEU A 125
LEU A  32
 None
 1.34A 5dzke-5p60A:
undetectable
5dzks-5p60A:
undetectable		 5dzke-5p60A:
20.41
5dzks-5p60A:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 7 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.14A 5h3aB-5p60A:
undetectable		 5h3aB-5p60A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 7 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.16A 5nooA-5p60A:
undetectable		 5nooA-5p60A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 7 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.13A 5nooB-5p60A:
undetectable		 5nooB-5p60A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 6 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.12A 5nooC-5p60A:
undetectable		 5nooC-5p60A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 6 PHE A 130
LEU A 128
TRP A 195
GLY A  37
 None
 0.94A 5o4yA-5p60A:
undetectable		 5o4yA-5p60A:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		4 / 6 PHE A 130
LEU A 128
TRP A 195
GLY A  37
 None
 1.12A 5o4yF-5p60A:
undetectable		 5o4yF-5p60A:
3.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 12 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.18A 5x5qB-5p60A:
undetectable		 5x5qB-5p60A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 7 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.14A 5x5qC-5p60A:
undetectable		 5x5qC-5p60A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 8 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.13A 5x5qD-5p60A:
undetectable		 5x5qD-5p60A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 5p60 ENDOTHIAPEPSIN
(Cryphonectria
parasitica) 		5 / 8 ASP A 307
LEU A 310
GLY A 306
PHE A 305
TYR A  17
 None
 1.14A 5x5qF-5p60A:
undetectable		 5x5qF-5p60A:
18.77