SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5pfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CUT_A_TYLA2971_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5pfr BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B
(Homo
sapiens) 		4 / 4 VAL A1893
VAL A1898
ASN A1944
ILE A1950
 None
None
EDO  A2001 (-3.2A)
EDO  A2001 ( 4.6A)
 0.16A 4cutA-5pfrA:
22.0		 4cutA-5pfrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 5pfr BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B
(Homo
sapiens) 		4 / 8 GLU A1916
GLN A1922
GLY A1921
SER A1920
 None
 0.72A 4f93B-5pfrA:
undetectable		 4f93B-5pfrA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 5pfr BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B
(Homo
sapiens) 		3 / 3 TRP A1965
GLU A1927
ASP A1869
 None
 0.96A 5gqbA-5pfrA:
undetectable		 5gqbA-5pfrA:
13.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5pfr BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B
(Homo
sapiens) 		6 / 6 PRO A1888
VAL A1893
VAL A1898
TYR A1901
ASN A1944
ILE A1950
 None
None
None
None
EDO  A2001 (-3.2A)
EDO  A2001 ( 4.6A)
 0.16A 5pbeA-5pfrA:
22.1		 5pbeA-5pfrA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5pfr BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B
(Homo
sapiens) 		4 / 8 VAL A1893
CYH A1940
ASN A1944
ILE A1950
 None
None
EDO  A2001 (-3.2A)
EDO  A2001 ( 4.6A)
 0.57A 5y1yA-5pfrA:
15.6		 5y1yA-5pfrA:
29.50