SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5sga'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_N_TRPN81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		5 / 10 GLY E 211
ALA E 130
ILE E 181
GLY E 202
THR E 208
 None
 1.19A 1c9sN-5sgaE:
undetectable
1c9sO-5sgaE:
undetectable		 1c9sN-5sgaE:
18.68
1c9sO-5sgaE:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_Q_TRPQ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		5 / 9 GLY E 211
ALA E 130
ILE E 181
GLY E 202
THR E 208
 None
 1.21A 1c9sQ-5sgaE:
undetectable
1c9sR-5sgaE:
undetectable		 1c9sQ-5sgaE:
18.68
1c9sR-5sgaE:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTF_R_TRPR81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN
(TRAP))		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		5 / 9 GLY E 211
ALA E 130
ILE E 181
GLY E 202
THR E 208
 None
 1.20A 1gtfR-5sgaE:
undetectable
1gtfS-5sgaE:
undetectable		 1gtfR-5sgaE:
18.68
1gtfS-5sgaE:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		5 / 10 GLY E 211
ALA E 130
ILE E 181
GLY E 202
THR E 208
 None
 1.20A 1utdU-5sgaE:
undetectable
1utdV-5sgaE:
undetectable		 1utdU-5sgaE:
18.68
1utdV-5sgaE:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		5 / 12 GLY E 196
GLY E 140
GLN E 229
ASP E 102
SER E 214
 None
 1.22A 1wg8A-5sgaE:
undetectable		 1wg8A-5sgaE:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		4 / 6 GLU E 233
GLY E 179
MET E 180
ASN E 100
 None
 1.10A 3e9rA-5sgaE:
undetectable		 3e9rA-5sgaE:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		5 / 12 ILE E 124
ALA E 127
LEU E 235
LEU E 212
LEU E  44
 None
 1.13A 3ix9A-5sgaE:
undetectable		 3ix9A-5sgaE:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IX9_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		5 / 12 ILE E 124
ALA E 127
LEU E 235
LEU E 212
LEU E  44
 None
 1.17A 3ix9B-5sgaE:
undetectable		 3ix9B-5sgaE:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		4 / 6 GLY E  18
GLY E  19
SER E 198
LEU E 157
 None
 0.80A 3o9mB-5sgaE:
undetectable		 3o9mB-5sgaE:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_2
(SECRETED ASPARTIC
PROTEASE)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		4 / 6 SER E 195
VAL E 177
THR E 226
THR E 225
 None
 0.84A 3tneA-5sgaE:
undetectable		 3tneA-5sgaE:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		4 / 7 SER E 195
VAL E 177
THR E 226
THR E 225
 None
 0.82A 3tneB-5sgaE:
undetectable		 3tneB-5sgaE:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		5 / 9 GLY E 197
GLY E  45
ASN E  47
SER E 141
GLY E 140
 None
 1.19A 3ztvA-5sgaE:
undetectable		 3ztvA-5sgaE:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		5 / 9 ASP E 123
ILE E 124
GLY E 116
VAL E 231
GLY E  45
 None
 1.37A 4acaB-5sgaE:
3.1
4acaC-5sgaE:
3.2		 4acaB-5sgaE:
18.31
4acaC-5sgaE:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		4 / 8 LEU E 235
ILE E 124
VAL E 118
GLY E 211
 None
 0.90A 4eq4B-5sgaE:
undetectable		 4eq4B-5sgaE:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		5 / 9 THR E  54
GLY E  45
ALA E  52
GLU E  29
SER E 141
 None
 0.91A 5vw4A-5sgaE:
undetectable		 5vw4A-5sgaE:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		5 / 12 VAL E 241
GLY E  18
GLY E  45
ALA E  17
TYR E 121
 None
 1.01A 5x7fA-5sgaE:
undetectable		 5x7fA-5sgaE:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		4 / 5 ALA E  30
SER E  43
GLY E 140
TYR E 120
 None
 1.20A 5yodB-5sgaE:
10.3		 5yodB-5sgaE:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 5sga PROTEINASE A (SGPA)
(Streptomyces
griseus) 		4 / 5 ALA E  30
SER E  43
GLY E 140
TYR E 120
 None
 1.11A 5yodD-5sgaE:
5.9		 5yodD-5sgaE:
23.67