SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5sup'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 368
LEU A 221
ASP A 218
LEU A 250
 None
 1.15A 1n13B-5supA:
undetectable
1n13C-5supA:
undetectable		 1n13B-5supA:
15.72
1n13C-5supA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		4 / 5 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 1.08A 1rs7A-5supA:
undetectable		 1rs7A-5supA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		6 / 10 GLY A 111
PHE A 246
SER A 247
ALA A 248
SER A 108
GLY A 109
 ADP  A1000 ( 3.3A)
None
None
BEF  A1001 ( 3.9A)
BEF  A1001 ( 4.2A)
ADP  A1000 ( 3.2A)
 0.95A 1stfE-5supA:
undetectable
1stfI-5supA:
undetectable		 1stfE-5supA:
18.27
1stfI-5supA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TD7_A_NFLA2001_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 121
ILE A  77
PHE A  64
TYR A 150
PHE A  82
 None
None
ADP  A1000 ( 4.6A)
None
ADP  A1000 ( 3.7A)
 1.48A 1td7A-5supA:
undetectable		 1td7A-5supA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		4 / 4 ARG A 368
GLY A 367
GLU A 216
SER A 408
 None
None
BEF  A1001 ( 4.0A)
None
 1.23A 2xctS-5supA:
undetectable
2xctU-5supA:
undetectable		 2xctS-5supA:
21.41
2xctU-5supA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OSH_A_OINA5811_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 121
PHE A 153
ILE A  77
PHE A  64
TYR A 150
 None
None
None
ADP  A1000 ( 4.6A)
None
 1.47A 3oshA-5supA:
undetectable		 3oshA-5supA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 227
ARG A 228
ILE A 257
 None
 0.84A 4b7qA-5supA:
undetectable		 4b7qA-5supA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 227
ARG A 228
ILE A 257
 None
 0.80A 4b7qC-5supA:
undetectable		 4b7qC-5supA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		4 / 5 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 0.98A 4d33A-5supA:
undetectable		 4d33A-5supA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		4 / 5 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 0.97A 4d33B-5supA:
undetectable		 4d33B-5supA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		4 / 6 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 0.95A 4d39B-5supA:
undetectable		 4d39B-5supA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 131
VAL A 209
MET A 244
VAL A 243
 None
 1.00A 4e1gB-5supA:
undetectable		 4e1gB-5supA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		4 / 6 GLY A  99
ILE A  97
VAL A 102
SER A 119
 None
 1.09A 4kcnA-5supA:
undetectable		 4kcnA-5supA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 157
VAL A 160
VAL A 117
LEU A 121
VAL A 189
 None
 1.41A 4m11C-5supA:
undetectable		 4m11C-5supA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		5 / 12 MET A 157
VAL A 160
VAL A 117
LEU A 121
VAL A 189
 None
 1.40A 4m11D-5supA:
undetectable		 4m11D-5supA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 273
ALA A 274
PHE A 426
 None
 0.67A 4v1fC-5supA:
undetectable		 4v1fC-5supA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 5sup ATP-DEPENDENT RNA
HELICASE SUB2
(Saccharomyces
cerevisiae) 		5 / 9 ASP A 371
ILE A 370
GLY A 367
VAL A 309
ILE A 375
 ADP  A1000 ( 2.5A)
None
None
None
None
 1.13A 5kr0A-5supA:
undetectable		 5kr0A-5supA:
14.62