SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5sv0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		3 / 3 TRP B 150
ALA B  19
VAL B  22
 None
 0.89A 1av2C-5sv0B:
undetectable
1av2D-5sv0B:
undetectable		 1av2C-5sv0B:
8.73
1av2D-5sv0B:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		4 / 7 GLY B 158
ILE B 157
ALA B 177
ILE B 174
 None
 0.75A 1n49A-5sv0B:
undetectable		 1n49A-5sv0B:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		3 / 3 TRP B 150
ALA B  19
VAL B  22
 None
 0.92A 1w5uA-5sv0B:
undetectable
1w5uB-5sv0B:
undetectable		 1w5uA-5sv0B:
8.73
1w5uB-5sv0B:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		3 / 3 ALA B  19
VAL B  22
TRP B 150
 None
 0.81A 2izqA-5sv0B:
undetectable
2izqB-5sv0B:
undetectable		 2izqA-5sv0B:
8.73
2izqB-5sv0B:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		3 / 3 LYS B 206
ARG B 124
VAL B 122
 None
 1.08A 2r2vC-5sv0B:
undetectable
2r2vD-5sv0B:
undetectable		 2r2vC-5sv0B:
10.81
2r2vD-5sv0B:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		3 / 3 TRP B 150
ALA B  19
VAL B  22
 None
 0.95A 3l8lA-5sv0B:
undetectable
3l8lB-5sv0B:
undetectable		 3l8lA-5sv0B:
8.73
3l8lB-5sv0B:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		4 / 5 GLU B  99
GLU B  94
THR B 111
LEU B  68
 None
None
MLY  B 108 ( 4.5A)
None
 1.26A 5hm8A-5sv0B:
undetectable		 5hm8A-5sv0B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		4 / 5 GLU B  99
GLU B  94
THR B 111
LEU B  68
 None
None
MLY  B 108 ( 4.5A)
None
 1.26A 5hm8C-5sv0B:
undetectable		 5hm8C-5sv0B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		4 / 5 GLU B  99
GLU B  94
THR B 111
LEU B  68
 None
None
MLY  B 108 ( 4.5A)
None
 1.26A 5hm8D-5sv0B:
undetectable		 5hm8D-5sv0B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		4 / 5 GLU B  99
GLU B  94
THR B 111
LEU B  68
 None
None
MLY  B 108 ( 4.5A)
None
 1.26A 5hm8E-5sv0B:
undetectable		 5hm8E-5sv0B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		4 / 5 GLU B  99
GLU B  94
THR B 111
LEU B  68
 None
None
MLY  B 108 ( 4.5A)
None
 1.26A 5hm8F-5sv0B:
undetectable		 5hm8F-5sv0B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		4 / 5 GLU B  99
GLU B  94
THR B 111
LEU B  68
 None
None
MLY  B 108 ( 4.5A)
None
 1.26A 5hm8H-5sv0B:
undetectable		 5hm8H-5sv0B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		3 / 3 MET B 126
GLN B 125
ARG B 124
 None
 1.10A 5m35B-5sv0B:
3.8		 5m35B-5sv0B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		3 / 3 MET B 126
GLN B 125
ARG B 124
 None
 1.11A 5m36A-5sv0B:
3.5		 5m36A-5sv0B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		4 / 8 GLY B 144
GLY B 184
LEU B 185
ALA B 188
 None
 0.68A 5vw5A-5sv0B:
undetectable		 5vw5A-5sv0B:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		3 / 3 LEU B 115
ASN B  72
LEU B  95
 None
 0.69A 6exiD-5sv0B:
undetectable		 6exiD-5sv0B:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		3 / 3 MET B 126
GLN B 125
ARG B 124
 None
 1.12A 6fn9A-5sv0B:
4.2		 6fn9A-5sv0B:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		3 / 3 MET B 126
GLN B 125
ARG B 124
 None
 1.09A 6fnaB-5sv0B:
4.2		 6fnaB-5sv0B:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB
(Escherichia
coli) 		3 / 3 MET B 126
GLN B 125
ARG B 124
 None
 1.12A 6fnbA-5sv0B:
4.0		 6fnbA-5sv0B:
22.47