SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5sva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GM7_B_PNNB1577_0 (PENICILLIN G ACYLASE ALPHA SUBUNIT PENICILLIN G ACYLASE BETA SUBUNIT)	5sva	DNA REPAIR HELICASE RAD3 (Saccharomyces cerevisiae)	4 / 8	SER Y 702 ALA Y 698 PHE Y 686 ILE Y 697	None	1.09A	1gm7A-5svaY: undetectable 1gm7B-5svaY: undetectable	1gm7A-5svaY: 14.93 1gm7B-5svaY: 21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_B_CHDB2501_0 (FERROCHELATASE)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	LEU X 85 LEU X 58 ILE X 36 PRO U 17 VAL U 20	None	1.34A	1hrkB-5svaX: undetectable	1hrkB-5svaX: 18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NP1_A_HSMA303_1 (NITROPHORIN 1)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 (Saccharomyces cerevisiae)	4 / 5	GLU U 180 LEU U 178 LEU U 177 LEU U 182	None	1.14A	1np1A-5svaU: undetectable	1np1A-5svaU: 21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WG8_A_SAMA3142_0 (PREDICTED S-ADENOSYLMETHIONINE -DEPENDENT METHYLTRANSFERASE)	5sva	DNA REPAIR HELICASE RAD3 (Saccharomyces cerevisiae)	5 / 12	GLY Y 36 GLY Y 35 PHE Y 234 SER Y 454 ARG Y 67	None	1.16A	1wg8A-5svaY: 2.0	1wg8A-5svaY: 17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_D_TFPD205_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 (Saccharomyces cerevisiae)	5 / 10	GLU U 172 ALA W 87 LEU W 91 GLN W 90 GLU U 179	None	1.48A	1wrlC-5svaU: undetectable 1wrlD-5svaU: undetectable	1wrlC-5svaU: 17.22 1wrlD-5svaU: 17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AB2_A_SNLA502_2 (MINERALOCORTICOID RECEPTOR)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 (Saccharomyces cerevisiae)	4 / 6	LEU U 155 LEU U 122 LEU U 123 LEU U 162	None	0.95A	2ab2A-5svaU: undetectable	2ab2A-5svaU: 22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACL_A_REAA502_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 (Saccharomyces cerevisiae)	5 / 12	GLN W 7 ASN W 74 LEU W 76 LEU W 5 LEU U 122	None	1.03A	2aclA-5svaW: undetectable 2aclE-5svaW: undetectable	2aclA-5svaW: 22.27 2aclE-5svaW: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F78_A_BEZA1001_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	LEU W 80 ILE W 73 LEU U 119 ARG U 120 ILE U 116	None	1.09A	2f78A-5svaW: undetectable	2f78A-5svaW: 23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F78_B_BEZB1002_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	LEU W 80 ILE W 73 LEU U 119 ARG U 120 ILE U 116	None	1.12A	2f78B-5svaW: undetectable	2f78B-5svaW: 23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F7A_A_BEZA1003_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 9	LEU W 80 ILE W 73 LEU U 119 ARG U 120 ILE U 116	None	1.03A	2f7aA-5svaW: undetectable	2f7aA-5svaW: 23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2F8D_A_BEZA1002_0 (HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 10	LEU W 80 ILE W 73 LEU U 119 ARG U 120 ILE U 116	None	1.08A	2f8dA-5svaW: undetectable	2f8dA-5svaW: 23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OPX_A_DXCA1002_0 (ALDEHYDE DEHYDROGENASE A)	5sva	DNA REPAIR HELICASE RAD3 (Saccharomyces cerevisiae)	3 / 3	GLY Y 536 ARG Y 618 TYR Y 586	None	0.87A	2opxA-5svaY: undetectable	2opxA-5svaY: 21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PNJ_B_CHDB501_0 (FERROCHELATASE, MITOCHONDRIAL)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	LEU X 85 LEU X 58 ILE X 36 PRO U 17 VAL U 20	None	1.35A	2pnjB-5svaX: undetectable	2pnjB-5svaX: 18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO5_B_CHDB501_0 (FERROCHELATASE, MITOCHONDRIAL)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 11	MET X 89 LEU X 85 LEU X 58 PRO U 16 VAL U 20	None	1.31A	2po5B-5svaX: undetectable	2po5B-5svaX: 18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ADS_A_IMNA1_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	5sva	DNA REPAIR HELICASE RAD3 (Saccharomyces cerevisiae)	5 / 10	GLU Y 640 GLY Y 415 CYH Y 439 ARG Y 436 ILE Y 634	None	1.45A	3adsA-5svaY: undetectable	3adsA-5svaY: 16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G4L_D_ROFD904_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5sva	DNA REPAIR HELICASE RAD3 (Saccharomyces cerevisiae)	3 / 3	ASN Y 707 MET Y 537 PHE Y 529	None	1.11A	3g4lD-5svaY: undetectable	3g4lD-5svaY: 18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GN8_A_DEXA247_2 (GLUCOCORTICOID RECEPTOR 2)	5sva	DNA REPAIR HELICASE RAD3 (Saccharomyces cerevisiae)	3 / 3	MET Y 679 MET Y 525 PHE Y 540	None	1.21A	3gn8A-5svaY: undetectable	3gn8A-5svaY: 16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H5G_C_LEIC16_0 (COIL SER L16D-PEN)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 (Saccharomyces cerevisiae)	4 / 6	LEU U 122 GLN U 117 LEU U 119 GLU U 118	None	1.11A	3h5gB-5svaU: undetectable 3h5gC-5svaU: undetectable	3h5gB-5svaU: 9.81 3h5gC-5svaU: 9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K37_A_BCZA468_1 (NEURAMINIDASE)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9 (Saccharomyces cerevisiae)	3 / 3	ASP V 141 ARG V 137 ARG V 149	None	0.96A	3k37A-5svaV: undetectable	3k37A-5svaV: 14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RV5_A_DXCA91_0 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae)	3 / 3	PHE X 54 GLN X 46 PHE X 29	None	0.82A	3rv5A-5svaX: undetectable	3rv5A-5svaX: 18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UJ7_B_SAMB302_1 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 5	TYR k 17 SER k 11 ASP X 97 ASP X 104	None	1.24A	3uj7B-5svak: undetectable	3uj7B-5svak: 4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_A_CHDA1502_0 (FERROCHELATASE, MITOCHONDRIAL)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	LEU X 85 LEU X 58 ILE X 36 PRO U 17 VAL U 20	None	1.33A	3w1wA-5svaX: undetectable	3w1wA-5svaX: 17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_B_CHDB504_0 (FERROCHELATASE, MITOCHONDRIAL)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	LEU X 85 LEU X 58 ILE X 36 PRO U 17 VAL U 20	None	1.31A	3w1wB-5svaX: undetectable	3w1wB-5svaX: 17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F8Y_D_VK3D202_1 (NADPH QUINONE OXIDOREDUCTASE)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae)	4 / 5	ARG X 22 TYR X 63 TYR X 60 LEU X 61	None	1.44A	4f8yC-5svaX: undetectable 4f8yD-5svaX: undetectable	4f8yC-5svaX: 22.22 4f8yD-5svaX: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_C_SAMC401_1 (METHYLTRANSFERASE NSUN4)	5sva	DNA REPAIR HELICASE RAD3 (Saccharomyces cerevisiae)	3 / 3	ASP Y 102 ARG Y 104 ASP Y 91	None	0.51A	4fp9C-5svaY: undetectable	4fp9C-5svaY: 18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_F_SAMF401_1 (METHYLTRANSFERASE NSUN4)	5sva	DNA REPAIR HELICASE RAD3 (Saccharomyces cerevisiae)	3 / 3	ASP Y 102 ARG Y 104 ASP Y 91	None	0.59A	4fp9F-5svaY: undetectable	4fp9F-5svaY: 18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G10_A_ACTA301_0 (GLUTATHIONE S-TRANSFERASE HOMOLOG)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 6	PRO U 17 TYR X 57 TYR X 60 PHE U 23	None	1.21A	4g10A-5svaU: undetectable	4g10A-5svaU: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MMC_A_29JA604_1 (TRANSPORTER)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 (Saccharomyces cerevisiae)	4 / 7	ARG U 152 ILE U 158 LEU W 12 ASP W 13	None	0.87A	4mmcA-5svaU: 3.2	4mmcA-5svaU: 15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVP_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5sva	DNA REPAIR HELICASE RAD3 (Saccharomyces cerevisiae)	5 / 10	THR Y 31 ALA Y 58 THR Y 477 GLY Y 35 GLY Y 36	None	0.98A	4qvpK-5svaY: undetectable 4qvpL-5svaY: undetectable	4qvpK-5svaY: 13.72 4qvpL-5svaY: 15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVP_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5sva	DNA REPAIR HELICASE RAD3 (Saccharomyces cerevisiae)	5 / 10	THR Y 31 ALA Y 58 THR Y 477 GLY Y 35 GLY Y 36	None	0.97A	4qvpY-5svaY: undetectable 4qvpZ-5svaY: undetectable	4qvpY-5svaY: 13.72 4qvpZ-5svaY: 15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_C_377C401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae)	4 / 6	TYR X 63 TYR X 57 LEU X 58 PHE X 29	None	1.00A	4twdB-5svaX: undetectable 4twdC-5svaX: undetectable	4twdB-5svaX: 16.27 4twdC-5svaX: 16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_E_377E401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae)	4 / 6	TYR X 63 TYR X 57 LEU X 58 PHE X 29	None	0.92A	4twdD-5svaX: undetectable 4twdE-5svaX: undetectable	4twdD-5svaX: 16.27 4twdE-5svaX: 16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_F_377F401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae)	4 / 7	TYR X 57 LEU X 58 PHE X 29 TYR X 63	None	1.02A	4twdF-5svaX: 2.1 4twdJ-5svaX: undetectable	4twdF-5svaX: 16.27 4twdJ-5svaX: 16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_G_377G401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae)	4 / 6	TYR X 63 TYR X 57 LEU X 58 PHE X 29	None	0.96A	4twdF-5svaX: 2.1 4twdG-5svaX: undetectable	4twdF-5svaX: 16.27 4twdG-5svaX: 16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_J_377J401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31 (Saccharomyces cerevisiae)	4 / 6	TYR X 63 TYR X 57 LEU X 58 PHE X 29	None	1.05A	4twdI-5svaX: undetectable 4twdJ-5svaX: undetectable	4twdI-5svaX: 16.27 4twdJ-5svaX: 16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UMJ_A_BFQA1297_1 (GERANYLTRANSTRANSFER ASE)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 (Saccharomyces cerevisiae)	4 / 8	LEU W 68 ASP W 65 MET W 15 GLN W 18	None	1.03A	4umjA-5svaW: undetectable	4umjA-5svaW: 15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YIA_B_IMNB401_1 (THYROXINE-BINDING GLOBULIN)	5sva	DNA REPAIR HELICASE RAD3 (Saccharomyces cerevisiae)	5 / 10	LEU Y 171 LEU Y 181 SER Y 110 LEU Y 114 LEU Y 190	None	1.22A	4yiaA-5svaY: undetectable	4yiaA-5svaY: 18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IFU_A_GBMA801_1 (PROLINE--TRNA LIGASE)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 (Saccharomyces cerevisiae)	5 / 12	LEU U 126 THR W 70 ARG W 71 ILE W 73 ILE W 77	None	1.18A	5ifuA-5svaU: undetectable	5ifuA-5svaU: 19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGV_A_ZITA404_2 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	5sva	DNA REPAIR HELICASE RAD3 (Saccharomyces cerevisiae)	4 / 4	ASN Y 239 ILE Y 70 TYR Y 71 PHE Y 178	None	1.05A	5igvA-5svaY: undetectable	5igvA-5svaY: 15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IWU_A_ACTA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 6	PHE T 81 TYR T 49 ILE V 76 ASP V 79	None	1.26A	5iwuA-5svaT: undetectable	5iwuA-5svaT: 22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JS5_A_ASCA202_0 (CYTOCHROME C')	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 (Saccharomyces cerevisiae)	3 / 3	CYH U 196 LYS U 197 HIS U 200	None	1.05A	5js5A-5svaU: 3.2	5js5A-5svaU: 16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N0T_A_SAMA501_0 (PEPTIDE N-METHYLTRANSFERASE)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	ILE W 26 GLY W 31 TYR U 130 ILE U 151 VAL U 148	None	1.09A	5n0tA-5svaW: undetectable	5n0tA-5svaW: 15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N0X_A_SAMA501_0 (PEPTIDE N-METHYLTRANSFERASE)	5sva	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7 MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	ILE W 26 GLY W 31 TYR U 130 ILE U 151 VAL U 148	None	1.07A	5n0xA-5svaW: undetectable	5n0xA-5svaW: 15.61

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1GM7_B_PNNB1577_0","PENICILLIN G ACYLASE ALPHA SUBUNIT;PENICILLIN G ACYLASE BETA SUBUNIT","5sva","DNA REPAIR HELICASE RAD3","Saccharomyces cerevisiae",4,"SER Y 702;ALA Y 698;PHE Y 686;ILE Y 697","None","1.09A","1gm7A-5svaY:undetectable;1gm7B-5svaY:undetectable","1gm7A-5svaY:14.93;1gm7B-5svaY:21.59"],["1HRK_B_CHDB2501_0","FERROCHELATASE","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae;Saccharomyces cerevisiae",5,"LEU X  85;LEU X  58;ILE X  36;PRO U  17;VAL U  20","None","1.34A","1hrkB-5svaX:undetectable","1hrkB-5svaX:18.84"],["1NP1_A_HSMA303_1","NITROPHORIN 1","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7","Saccharomyces cerevisiae",4,"GLU U 180;LEU U 178;LEU U 177;LEU U 182","None","1.14A","1np1A-5svaU:undetectable","1np1A-5svaU:21.55"],["1WG8_A_SAMA3142_0","PREDICTED S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE","5sva","DNA REPAIR HELICASE RAD3","Saccharomyces cerevisiae",5,"GLY Y  36;GLY Y  35;PHE Y 234;SER Y 454;ARG Y  67","None","1.16A","1wg8A-5svaY:2.0","1wg8A-5svaY:17.41"],["1WRL_D_TFPD205_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES;TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7","Saccharomyces cerevisiae",5,"GLU U 172;ALA W  87;LEU W  91;GLN W  90;GLU U 179","None","1.48A","1wrlC-5svaU:undetectable;1wrlD-5svaU:undetectable","1wrlC-5svaU:17.22;1wrlD-5svaU:17.22"],["2AB2_A_SNLA502_2","MINERALOCORTICOID RECEPTOR","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7","Saccharomyces cerevisiae",4,"LEU U 155;LEU U 122;LEU U 123;LEU U 162","None","0.95A","2ab2A-5svaU:undetectable","2ab2A-5svaU:22.60"],["2ACL_A_REAA502_1","RETINOIC ACID RECEPTOR RXR-ALPHA;RETINOIC ACID RECEPTOR RXR-ALPHA","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7","Saccharomyces cerevisiae",5,"GLN W   7;ASN W  74;LEU W  76;LEU W   5;LEU U 122","None","1.03A","2aclA-5svaW:undetectable;2aclE-5svaW:undetectable","2aclA-5svaW:22.27;2aclE-5svaW:22.27"],["2F78_A_BEZA1001_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21","Saccharomyces cerevisiae;Saccharomyces cerevisiae",5,"LEU W  80;ILE W  73;LEU U 119;ARG U 120;ILE U 116","None","1.09A","2f78A-5svaW:undetectable","2f78A-5svaW:23.38"],["2F78_B_BEZB1002_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21","Saccharomyces cerevisiae;Saccharomyces cerevisiae",5,"LEU W  80;ILE W  73;LEU U 119;ARG U 120;ILE U 116","None","1.12A","2f78B-5svaW:undetectable","2f78B-5svaW:23.38"],["2F7A_A_BEZA1003_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21","Saccharomyces cerevisiae;Saccharomyces cerevisiae",5,"LEU W  80;ILE W  73;LEU U 119;ARG U 120;ILE U 116","None","1.03A","2f7aA-5svaW:undetectable","2f7aA-5svaW:23.38"],["2F8D_A_BEZA1002_0","HTH-TYPE TRANSCRIPTIONAL REGULATOR BENM","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21","Saccharomyces cerevisiae;Saccharomyces cerevisiae",5,"LEU W  80;ILE W  73;LEU U 119;ARG U 120;ILE U 116","None","1.08A","2f8dA-5svaW:undetectable","2f8dA-5svaW:23.38"],["2OPX_A_DXCA1002_0","ALDEHYDE DEHYDROGENASE A","5sva","DNA REPAIR HELICASE RAD3","Saccharomyces cerevisiae",3,"GLY Y 536;ARG Y 618;TYR Y 586","None","0.87A","2opxA-5svaY:undetectable","2opxA-5svaY:21.47"],["2PNJ_B_CHDB501_0","FERROCHELATASE, MITOCHONDRIAL","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae;Saccharomyces cerevisiae",5,"LEU X  85;LEU X  58;ILE X  36;PRO U  17;VAL U  20","None","1.35A","2pnjB-5svaX:undetectable","2pnjB-5svaX:18.55"],["2PO5_B_CHDB501_0","FERROCHELATASE, MITOCHONDRIAL","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae;Saccharomyces cerevisiae",5,"MET X  89;LEU X  85;LEU X  58;PRO U  16;VAL U  20","None","1.31A","2po5B-5svaX:undetectable","2po5B-5svaX:18.84"],["3ADS_A_IMNA1_1","PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA","5sva","DNA REPAIR HELICASE RAD3","Saccharomyces cerevisiae",5,"GLU Y 640;GLY Y 415;CYH Y 439;ARG Y 436;ILE Y 634","None","1.45A","3adsA-5svaY:undetectable","3adsA-5svaY:16.89"],["3G4L_D_ROFD904_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","5sva","DNA REPAIR HELICASE RAD3","Saccharomyces cerevisiae",3,"ASN Y 707;MET Y 537;PHE Y 529","None","1.11A","3g4lD-5svaY:undetectable","3g4lD-5svaY:18.60"],["3GN8_A_DEXA247_2","GLUCOCORTICOID RECEPTOR 2","5sva","DNA REPAIR HELICASE RAD3","Saccharomyces cerevisiae",3,"MET Y 679;MET Y 525;PHE Y 540","None","1.21A","3gn8A-5svaY:undetectable","3gn8A-5svaY:16.33"],["3H5G_C_LEIC16_0","COIL SER L16D-PEN","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7","Saccharomyces cerevisiae",4,"LEU U 122;GLN U 117;LEU U 119;GLU U 118","None","1.11A","3h5gB-5svaU:undetectable;3h5gC-5svaU:undetectable","3h5gB-5svaU:9.81;3h5gC-5svaU:9.81"],["3K37_A_BCZA468_1","NEURAMINIDASE","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9","Saccharomyces cerevisiae",3,"ASP V 141;ARG V 137;ARG V 149","None","0.96A","3k37A-5svaV:undetectable","3k37A-5svaV:14.53"],["3RV5_A_DXCA91_0","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae",3,"PHE X  54;GLN X  46;PHE X  29","None","0.82A","3rv5A-5svaX:undetectable","3rv5A-5svaX:18.80"],["3UJ7_B_SAMB302_1","PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31;DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1","Saccharomyces cerevisiae;Saccharomyces cerevisiae",4,"TYR k  17;SER k  11;ASP X  97;ASP X 104","None","1.24A","3uj7B-5svak:undetectable","3uj7B-5svak:4.83"],["3W1W_A_CHDA1502_0","FERROCHELATASE, MITOCHONDRIAL","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae;Saccharomyces cerevisiae",5,"LEU X  85;LEU X  58;ILE X  36;PRO U  17;VAL U  20","None","1.33A","3w1wA-5svaX:undetectable","3w1wA-5svaX:17.81"],["3W1W_B_CHDB504_0","FERROCHELATASE, MITOCHONDRIAL","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae;Saccharomyces cerevisiae",5,"LEU X  85;LEU X  58;ILE X  36;PRO U  17;VAL U  20","None","1.31A","3w1wB-5svaX:undetectable","3w1wB-5svaX:17.81"],["4F8Y_D_VK3D202_1","NADPH QUINONE OXIDOREDUCTASE;NADPH QUINONE OXIDOREDUCTASE","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae",4,"ARG X  22;TYR X  63;TYR X  60;LEU X  61","None","1.44A","4f8yC-5svaX:undetectable;4f8yD-5svaX:undetectable","4f8yC-5svaX:22.22;4f8yD-5svaX:22.22"],["4FP9_C_SAMC401_1","METHYLTRANSFERASE NSUN4","5sva","DNA REPAIR HELICASE RAD3","Saccharomyces cerevisiae",3,"ASP Y 102;ARG Y 104;ASP Y  91","None","0.51A","4fp9C-5svaY:undetectable","4fp9C-5svaY:18.33"],["4FP9_F_SAMF401_1","METHYLTRANSFERASE NSUN4","5sva","DNA REPAIR HELICASE RAD3","Saccharomyces cerevisiae",3,"ASP Y 102;ARG Y 104;ASP Y  91","None","0.59A","4fp9F-5svaY:undetectable","4fp9F-5svaY:18.33"],["4G10_A_ACTA301_0","GLUTATHIONE S-TRANSFERASE HOMOLOG","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae;Saccharomyces cerevisiae",4,"PRO U  17;TYR X  57;TYR X  60;PHE U  23","None","1.21A","4g10A-5svaU:undetectable","4g10A-5svaU:20.59"],["4MMC_A_29JA604_1","TRANSPORTER","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7","Saccharomyces cerevisiae",4,"ARG U 152;ILE U 158;LEU W  12;ASP W  13","None","0.87A","4mmcA-5svaU:3.2","4mmcA-5svaU:15.46"],["4QVP_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5sva","DNA REPAIR HELICASE RAD3","Saccharomyces cerevisiae",5,"THR Y  31;ALA Y  58;THR Y 477;GLY Y  35;GLY Y  36","None","0.98A","4qvpK-5svaY:undetectable;4qvpL-5svaY:undetectable","4qvpK-5svaY:13.72;4qvpL-5svaY:15.60"],["4QVP_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5sva","DNA REPAIR HELICASE RAD3","Saccharomyces cerevisiae",5,"THR Y  31;ALA Y  58;THR Y 477;GLY Y  35;GLY Y  36","None","0.97A","4qvpY-5svaY:undetectable;4qvpZ-5svaY:undetectable","4qvpY-5svaY:13.72;4qvpZ-5svaY:15.60"],["4TWD_C_377C401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae",4,"TYR X  63;TYR X  57;LEU X  58;PHE X  29","None","1.00A","4twdB-5svaX:undetectable;4twdC-5svaX:undetectable","4twdB-5svaX:16.27;4twdC-5svaX:16.27"],["4TWD_E_377E401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae",4,"TYR X  63;TYR X  57;LEU X  58;PHE X  29","None","0.92A","4twdD-5svaX:undetectable;4twdE-5svaX:undetectable","4twdD-5svaX:16.27;4twdE-5svaX:16.27"],["4TWD_F_377F401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae",4,"TYR X  57;LEU X  58;PHE X  29;TYR X  63","None","1.02A","4twdF-5svaX:2.1;4twdJ-5svaX:undetectable","4twdF-5svaX:16.27;4twdJ-5svaX:16.27"],["4TWD_G_377G401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae",4,"TYR X  63;TYR X  57;LEU X  58;PHE X  29","None","0.96A","4twdF-5svaX:2.1;4twdG-5svaX:undetectable","4twdF-5svaX:16.27;4twdG-5svaX:16.27"],["4TWD_J_377J401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31","Saccharomyces cerevisiae",4,"TYR X  63;TYR X  57;LEU X  58;PHE X  29","None","1.05A","4twdI-5svaX:undetectable;4twdJ-5svaX:undetectable","4twdI-5svaX:16.27;4twdJ-5svaX:16.27"],["4UMJ_A_BFQA1297_1","GERANYLTRANSTRANSFERASE","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21","Saccharomyces cerevisiae",4,"LEU W  68;ASP W  65;MET W  15;GLN W  18","None","1.03A","4umjA-5svaW:undetectable","4umjA-5svaW:15.77"],["4YIA_B_IMNB401_1","THYROXINE-BINDING GLOBULIN;THYROXINE-BINDING GLOBULIN","5sva","DNA REPAIR HELICASE RAD3","Saccharomyces cerevisiae",5,"LEU Y 171;LEU Y 181;SER Y 110;LEU Y 114;LEU Y 190","None","1.22A","4yiaA-5svaY:undetectable","4yiaA-5svaY:18.86"],["5IFU_A_GBMA801_1","PROLINE--TRNA LIGASE","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7","Saccharomyces cerevisiae",5,"LEU U 126;THR W  70;ARG W  71;ILE W  73;ILE W  77","None","1.18A","5ifuA-5svaU:undetectable","5ifuA-5svaU:19.53"],["5IGV_A_ZITA404_2","MACROLIDE 2'-PHOSPHOTRANSFERASE II","5sva","DNA REPAIR HELICASE RAD3","Saccharomyces cerevisiae",4,"ASN Y 239;ILE Y  70;TYR Y  71;PHE Y 178","None","1.05A","5igvA-5svaY:undetectable","5igvA-5svaY:15.88"],["5IWU_A_ACTA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE II","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9","Saccharomyces cerevisiae;Saccharomyces cerevisiae",4,"PHE T  81;TYR T  49;ILE V  76;ASP V  79","None","1.26A","5iwuA-5svaT:undetectable","5iwuA-5svaT:22.49"],["5JS5_A_ASCA202_0","CYTOCHROME C'","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7","Saccharomyces cerevisiae",3,"CYH U 196;LYS U 197;HIS U 200","None","1.05A","5js5A-5svaU:3.2","5js5A-5svaU:16.51"],["5N0T_A_SAMA501_0","PEPTIDE N-METHYLTRANSFERASE","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21","Saccharomyces cerevisiae;Saccharomyces cerevisiae",5,"ILE W  26;GLY W  31;TYR U 130;ILE U 151;VAL U 148","None","1.09A","5n0tA-5svaW:undetectable","5n0tA-5svaW:15.61"],["5N0X_A_SAMA501_0","PEPTIDE N-METHYLTRANSFERASE","5sva","MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7;MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21","Saccharomyces cerevisiae;Saccharomyces cerevisiae",5,"ILE W  26;GLY W  31;TYR U 130;ILE U 151;VAL U 148","None","1.07A","5n0xA-5svaW:undetectable","5n0xA-5svaW:15.61"]]