SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5svc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 7 LEU A  47
TYR A  57
HIS A 270
ASN A 371
None
1.33A 1afsA-5svcA:
undetectable
1afsA-5svcA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 7 LEU A  47
TYR A  57
HIS A 270
ASN A 371
None
1.33A 1afsB-5svcA:
undetectable
1afsB-5svcA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
3 / 3 ALA A 129
VAL A 133
TRP A 127
None
0.87A 1bdwA-5svcA:
undetectable
1bdwB-5svcA:
undetectable
1bdwA-5svcA:
3.16
1bdwB-5svcA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 11 ARG A 524
LEU A 439
GLU A 457
PHE A 536
GLY A 557
None
1.25A 1cmaA-5svcA:
undetectable
1cmaB-5svcA:
undetectable
1cmaA-5svcA:
8.25
1cmaB-5svcA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 7 ILE A 599
ARG A 601
PHE A 536
PHE A 612
None
1.06A 1e71M-5svcA:
undetectable
1e71M-5svcA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 7 ILE A 599
ARG A 601
PHE A 536
PHE A 612
None
1.10A 1e72M-5svcA:
undetectable
1e72M-5svcA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 PHE A 652
PRO A 585
TYR A 621
GLN A 503
SER A 508
None
1.47A 1fm4A-5svcA:
undetectable
1fm4A-5svcA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 5 TRP A 162
ILE A 257
ASP A 135
ASN A 209
None
1.22A 1kiaD-5svcA:
undetectable
1kiaD-5svcA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 7 SER A 756
GLU A 747
GLU A 746
GLU A 748
None
1.15A 1knyA-5svcA:
undetectable
1knyB-5svcA:
undetectable
1knyA-5svcA:
14.60
1knyB-5svcA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 11 ARG A 524
LEU A 439
GLU A 457
PHE A 536
GLY A 557
None
1.22A 1mjqA-5svcA:
undetectable
1mjqB-5svcA:
undetectable
1mjqA-5svcA:
8.76
1mjqB-5svcA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 9 GLY A 464
PRO A 553
GLY A 510
GLY A 629
GLY A 550
None
0.94A 1mxdA-5svcA:
undetectable
1mxdA-5svcA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA442_1
(ALPHA AMYLASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 11 GLY A 464
PRO A 553
GLY A 510
GLY A 629
GLY A 550
None
0.97A 1mxgA-5svcA:
undetectable
1mxgA-5svcA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 HIS A 474
THR A 463
GLY A 517
GLY A 519
ASP A 470
None
1.16A 1n2xA-5svcA:
undetectable
1n2xA-5svcA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 517
GLY A 464
ALA A 433
SER A 508
SER A 473
None
1.14A 1ri4A-5svcA:
undetectable
1ri4A-5svcA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 6 TRP A 742
LEU A 738
TRP A 736
PHE A 732
None
1.05A 1ru9H-5svcA:
undetectable
1ru9L-5svcA:
undetectable
1ru9H-5svcA:
13.73
1ru9L-5svcA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 6 TRP A 742
LEU A 738
TRP A 736
PHE A 732
None
1.03A 1rukH-5svcA:
undetectable
1rukL-5svcA:
undetectable
1rukH-5svcA:
13.73
1rukL-5svcA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 PRO A 626
GLY A 629
GLY A 551
GLY A 547
ASP A 633
None
1.12A 1wg8A-5svcA:
undetectable
1wg8A-5svcA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 PRO A 553
GLY A 629
GLY A 550
GLY A 547
ASP A 633
None
1.13A 1wg8B-5svcA:
undetectable
1wg8B-5svcA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 PRO A 626
GLY A 629
GLY A 551
GLY A 547
ASP A 633
None
1.07A 1wg8B-5svcA:
undetectable
1wg8B-5svcA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLN A 191
ASP A 295
VAL A 296
ALA A 396
PHE A 397
None
1.36A 2g70A-5svcA:
undetectable
2g70A-5svcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLN A 191
ASP A 295
VAL A 296
ALA A 396
PHE A 397
None
1.32A 2g70B-5svcA:
undetectable
2g70B-5svcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 PHE A 456
ALA A  75
ALA A  79
GLY A 172
GLY A 240
None
0.97A 2igtA-5svcA:
undetectable
2igtA-5svcA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
3 / 3 TRP A 401
ALA A 347
VAL A 149
None
0.77A 2izqA-5svcA:
undetectable
2izqB-5svcA:
undetectable
2izqA-5svcA:
3.16
2izqB-5svcA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 624
GLY A 547
GLY A 627
GLY A 509
ASP A 545
None
1.05A 2oxtA-5svcA:
undetectable
2oxtA-5svcA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 11 HIS A 150
HIS A 111
ASP A 153
GLU A  89
HIS A 175
MN  A 801 (-2.9A)
None
MN  A 801 (-2.0A)
None
MN  A 801 (-3.1A)
1.20A 2q0jB-5svcA:
undetectable
2q0jB-5svcA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QK8_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 LEU A 744
ILE A 705
LEU A 738
PRO A 739
PHE A 732
None
1.01A 2qk8A-5svcA:
undetectable
2qk8A-5svcA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 7 TYR A 298
TYR A 345
GLN A 191
HIS A 343
None
1.24A 2qmqA-5svcA:
undetectable
2qmqA-5svcA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 8 ALA A  97
TYR A 265
GLY A 168
ILE A 167
None
0.91A 2zm9A-5svcA:
undetectable
2zm9A-5svcA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 SER A 186
ASN A 454
PHE A 536
GLY A 538
ASP A 602
None
1.47A 3a27A-5svcA:
undetectable
3a27A-5svcA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 SER A 398
PHE A 536
GLY A 538
TYR A 399
ASP A 602
None
1.49A 3a27A-5svcA:
undetectable
3a27A-5svcA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 6 GLY A 464
GLY A 625
GLY A 624
GLY A 517
GLY A 519
None
1.31A 3bogA-5svcA:
undetectable
3bogC-5svcA:
undetectable
3bogA-5svcA:
undetectable
3bogC-5svcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
3 / 3 GLY A 627
GLY A 471
GLY A 516
None
0.40A 3bogD-5svcA:
undetectable
3bogD-5svcA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 8 HIS A 270
GLY A 271
ASN A 371
PHE A  61
None
1.26A 3ccfA-5svcA:
undetectable
3ccfA-5svcA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 8 GLY A 624
GLY A 625
GLY A 464
SER A 473
None
0.53A 3d41A-5svcA:
undetectable
3d41A-5svcA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 624
GLY A 547
GLY A 627
GLY A 509
ASP A 545
None
1.09A 3eluA-5svcA:
undetectable
3eluA-5svcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 624
GLY A 547
GLY A 627
GLY A 509
ASP A 545
None
1.07A 3embA-5svcA:
undetectable
3embA-5svcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
3 / 3 THR A  14
GLU A 128
HIS A 134
None
0.56A 3g1uB-5svcA:
undetectable
3g1uB-5svcA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 SER A 508
GLY A 519
GLY A 471
GLY A 516
GLY A 624
None
1.02A 3gczA-5svcA:
undetectable
3gczA-5svcA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
3 / 3 ASN A 539
ASP A 545
ARG A 651
None
0.90A 3k13C-5svcA:
undetectable
3k13C-5svcA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
3 / 3 ALA A 347
VAL A 149
TRP A 401
None
0.75A 3l8lA-5svcA:
undetectable
3l8lB-5svcA:
undetectable
3l8lA-5svcA:
3.16
3l8lB-5svcA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
3 / 3 ALA A 347
VAL A 149
TRP A 401
None
0.62A 3l8lC-5svcA:
undetectable
3l8lD-5svcA:
undetectable
3l8lC-5svcA:
3.16
3l8lD-5svcA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_A_ACTA601_0
(CHOLINE OXIDASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 5 ILE A 108
HIS A 111
VAL A 149
HIS A 150
None
None
None
MN  A 801 (-2.9A)
1.34A 3nneA-5svcA:
undetectable
3nneA-5svcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 6 ALA A 605
ILE A 606
HIS A 402
VAL A 294
None
1.07A 3nneG-5svcA:
1.8
3nneG-5svcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_A_SAMA263_0
(NON-STRUCTURAL
PROTEIN 5)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.87A 3p97A-5svcA:
undetectable
3p97A-5svcA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.89A 3p97C-5svcA:
undetectable
3p97C-5svcA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
3 / 3 LYS A 505
ARG A 601
LEU A 619
None
1.42A 3v4tE-5svcA:
undetectable
3v4tE-5svcA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
3 / 3 GLN A 668
ASP A 641
GLN A 637
None
0.76A 4aztA-5svcA:
undetectable
4aztA-5svcA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 10 GLY A 113
ALA A 118
GLY A 116
VAL A 350
HIS A 348
None
1.33A 4c5nB-5svcA:
undetectable
4c5nB-5svcA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTJ_C_SAMC1263_0
(NON-STRUCTURAL
PROTEIN 5)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.88A 4ctjC-5svcA:
undetectable
4ctjC-5svcA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_A_SAMA1263_0
(POLYPROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.85A 4ctkA-5svcA:
undetectable
4ctkA-5svcA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.88A 4ctkC-5svcA:
undetectable
4ctkC-5svcA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
3 / 3 ARG A 339
TRP A 342
GLY A 341
None
0.94A 4e7cA-5svcA:
undetectable
4e7cA-5svcA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 6 PRO A 636
ARG A 680
GLY A 675
GLU A 673
None
1.10A 4g0uA-5svcA:
undetectable
4g0uA-5svcA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 7 THR A 314
SER A 338
PHE A 403
ASP A 545
None
1.37A 4iarA-5svcA:
undetectable
4iarA-5svcA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
3 / 3 HIS A 317
TRP A 546
SER A 721
None
1.18A 4lrhD-5svcA:
undetectable
4lrhD-5svcA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 6 ILE A 683
ARG A 684
ARG A 680
VAL A 639
None
1.29A 4mk4B-5svcA:
undetectable
4mk4B-5svcA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 471
ALA A 465
GLY A 517
GLY A 516
GLY A 462
None
0.91A 4o33A-5svcA:
undetectable
4o33A-5svcA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 471
ALA A 465
GLY A 517
GLY A 516
GLY A 462
None
0.87A 4o3fA-5svcA:
undetectable
4o3fA-5svcA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 7 GLY A 540
TYR A 621
SER A 556
ASN A 539
None
1.18A 4ws0A-5svcA:
undetectable
4ws0A-5svcA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 8 ASN A 389
PRO A 390
SER A 338
TRP A 387
None
1.12A 5amiB-5svcA:
undetectable
5amiB-5svcA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 ALA A 433
PRO A 626
GLY A 519
GLY A 624
GLY A 510
None
0.95A 5c0oE-5svcA:
undetectable
5c0oE-5svcA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 11 VAL A 248
VAL A 251
VAL A 252
PHE A 263
LEU A  64
None
0.93A 5e4dB-5svcA:
undetectable
5e4dB-5svcA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_A_SAMA301_0
(GENOME POLYPROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.87A 5e9qA-5svcA:
undetectable
5e9qA-5svcA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.89A 5e9qC-5svcA:
undetectable
5e9qC-5svcA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.87A 5ec8A-5svcA:
undetectable
5ec8A-5svcA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_C_SAMC4000_0
(GENOME POLYPROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.90A 5ec8C-5svcA:
undetectable
5ec8C-5svcA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.86A 5ehgA-5svcA:
undetectable
5ehgA-5svcA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.91A 5ehgC-5svcA:
undetectable
5ehgC-5svcA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_A_SAMA301_0
(GENOME POLYPROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.86A 5eifA-5svcA:
undetectable
5eifA-5svcA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIF_C_SAMC4000_0
(GENOME POLYPROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.89A 5eifC-5svcA:
undetectable
5eifC-5svcA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.86A 5ekxA-5svcA:
undetectable
5ekxA-5svcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.87A 5ekxB-5svcA:
undetectable
5ekxB-5svcA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 580
ILE A 177
GLY A 185
GLY A 441
LEU A 497
None
0.98A 5eqbA-5svcA:
undetectable
5eqbA-5svcA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 ALA A 259
LEU A  49
TYR A  41
TYR A 376
GLY A 116
None
1.10A 5eshA-5svcA:
undetectable
5eshA-5svcA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 5 GLY A 431
PRO A 481
THR A 463
GLN A 362
None
1.18A 5h5fA-5svcA:
undetectable
5h5fA-5svcA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 10 GLY A 274
GLY A 271
LEU A 273
LEU A  47
TYR A  57
None
1.31A 5hwkA-5svcA:
undetectable
5hwkA-5svcA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 10 GLY A 274
GLY A 271
LEU A 273
LEU A  47
TYR A  57
None
1.30A 5hwkB-5svcA:
undetectable
5hwkB-5svcA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKM_A_SAMA311_0
(NS5 METHYL
TRANSFERASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.92A 5ikmA-5svcA:
undetectable
5ikmA-5svcA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQS_A_SAMA307_0
(GENOME POLYPROTEIN)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.89A 5kqsA-5svcA:
undetectable
5kqsA-5svcA:
15.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M45_A_ACTA802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
6 / 6 HIS A 150
ASP A 153
HIS A 175
MET A 187
TRP A 401
TRP A 479
MN  A 801 (-2.9A)
MN  A 801 (-2.0A)
MN  A 801 (-3.1A)
None
None
None
0.37A 5m45A-5svcA:
59.4
5m45A-5svcA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 4 GLU A  53
PRO A  54
ILE A  55
LEU A  56
None
0.31A 5m45A-5svcA:
59.4
5m45A-5svcA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M45_D_ACTD802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
6 / 6 HIS A 150
ASP A 153
HIS A 175
MET A 187
TRP A 401
TRP A 479
MN  A 801 (-2.9A)
MN  A 801 (-2.0A)
MN  A 801 (-3.1A)
None
None
None
0.37A 5m45D-5svcA:
59.4
5m45D-5svcA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 4 GLU A  53
PRO A  54
ILE A  55
LEU A  56
None
0.36A 5m45D-5svcA:
59.4
5m45D-5svcA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M45_G_ACTG802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
6 / 6 HIS A 150
ASP A 153
HIS A 175
MET A 187
TRP A 401
TRP A 479
MN  A 801 (-2.9A)
MN  A 801 (-2.0A)
MN  A 801 (-3.1A)
None
None
None
0.36A 5m45G-5svcA:
59.5
5m45G-5svcA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 4 GLU A  53
PRO A  54
ILE A  55
LEU A  56
None
0.29A 5m45G-5svcA:
59.5
5m45G-5svcA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M45_J_ACTJ802_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
6 / 6 HIS A 150
ASP A 153
HIS A 175
MET A 187
TRP A 401
TRP A 479
MN  A 801 (-2.9A)
MN  A 801 (-2.0A)
MN  A 801 (-3.1A)
None
None
None
0.37A 5m45J-5svcA:
59.4
5m45J-5svcA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 4 GLU A  53
PRO A  54
ILE A  55
LEU A  56
None
0.38A 5m45J-5svcA:
59.4
5m45J-5svcA:
99.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.86A 5njvA-5svcA:
undetectable
5njvA-5svcA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_B_SAMB301_0
(NS5)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.87A 5njvB-5svcA:
undetectable
5njvB-5svcA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 431
GLY A 509
GLY A 624
HIS A 474
VAL A 648
None
0.89A 5njvC-5svcA:
undetectable
5njvC-5svcA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.88A 5njvC-5svcA:
undetectable
5njvC-5svcA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH8_A_ACTA302_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
3 / 3 CYH A 203
MET A 122
ASN A 125
None
1.24A 5qh8A-5svcA:
undetectable
5qh8A-5svcA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 ILE A 123
LEU A 166
VAL A  18
GLY A 373
TYR A 376
None
1.03A 5uxdB-5svcA:
undetectable
5uxdB-5svcA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 7 ASP A 178
THR A 179
TYR A 199
HIS A 111
None
1.07A 5w97C-5svcA:
undetectable
5w97a-5svcA:
undetectable
5w97c-5svcA:
undetectable
5w97C-5svcA:
14.42
5w97a-5svcA:
20.03
5w97c-5svcA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 5 LEU A  60
LYS A 262
LEU A  56
GLU A  53
None
1.34A 5weaA-5svcA:
undetectable
5weaA-5svcA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_A_SAMA601_0
(NS5 MTASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.91A 5wz2A-5svcA:
undetectable
5wz2A-5svcA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_B_SAMB601_0
(NS5 MTASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.87A 5wz2B-5svcA:
undetectable
5wz2B-5svcA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ2_C_SAMC601_0
(NS5 MTASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 12 GLY A 510
GLY A 431
GLY A 464
GLY A 627
ASP A 545
None
0.91A 5wz2C-5svcA:
undetectable
5wz2C-5svcA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 8 GLU A 321
PHE A 732
PHE A 718
MET A 717
None
0.85A 5y2tB-5svcA:
undetectable
5y2tB-5svcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 10 ALA A 605
ASP A 295
HIS A 541
THR A 189
VAL A 303
None
1.40A 6aogA-5svcA:
undetectable
6aogA-5svcA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
5 / 10 ALA A 605
ASP A 295
HIS A 541
THR A 189
VAL A 303
None
1.43A 6aogB-5svcA:
undetectable
6aogB-5svcA:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 5 TYR A 288
GLN A 290
GLY A 423
ILE A 284
None
1.27A 6debB-5svcA:
undetectable
6debB-5svcA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 5 ILE A 238
THR A 156
THR A 211
LEU A 217
None
1.13A 6f3mD-5svcA:
undetectable
6f3mD-5svcA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 5 ASN A 644
TYR A 657
GLY A 658
ASP A 642
None
1.22A 6gh9A-5svcA:
undetectable
6gh9A-5svcA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 8 ASP A 178
THR A 179
TYR A 199
HIS A 111
None
1.08A 6nknC-5svcA:
undetectable
6nknN-5svcA:
undetectable
6nknP-5svcA:
undetectable
6nknC-5svcA:
14.42
6nknN-5svcA:
20.03
6nknP-5svcA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus)
4 / 7 ASP A 178
THR A 179
TYR A 199
HIS A 111
None
1.09A 6nmpN-5svcA:
undetectable
6nmpP-5svcA:
undetectable
6nmpN-5svcA:
20.03
6nmpP-5svcA:
14.42