SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5svd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 461
LEU A 472
ILE A 518
ILE A 506
LEU A 510
 LEU  A 461 ( 0.6A)
LEU  A 472 ( 0.5A)
ILE  A 518 ( 0.7A)
ILE  A 506 ( 0.7A)
LEU  A 510 ( 0.6A)
 1.22A 1tw4B-5svdA:
undetectable		 1tw4B-5svdA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 517
MET A 509
LEU A 461
MET A 520
 LEU  A 517 ( 0.5A)
MET  A 509 ( 0.0A)
LEU  A 461 ( 0.6A)
MET  A 520 ( 0.0A)
 1.11A 2kuhA-5svdA:
undetectable		 2kuhA-5svdA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_2
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 351
PHE A 291
TRP A 321
GLN A 305
 PHE  A 351 ( 1.3A)
PHE  A 291 ( 1.3A)
TRP  A 321 ( 0.5A)
GLN  A 305 ( 0.6A)
 1.44A 4b9zA-5svdA:
0.0		 4b9zA-5svdA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 389
PHE A 338
GLY A 348
PHE A 325
 VAL  A 389 ( 0.6A)
PHE  A 338 ( 1.3A)
GLY  A 348 ( 0.0A)
PHE  A 325 ( 1.3A)
 0.94A 4ejjB-5svdA:
undetectable		 4ejjB-5svdA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 406
VAL A 409
LYS A 433
TYR A 497
 LEU  A 406 ( 0.5A)
VAL  A 409 ( 0.6A)
LYS  A 433 ( 0.0A)
TYR  A 497 ( 1.3A)
 1.13A 4lb2A-5svdA:
undetectable		 4lb2A-5svdA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 114
LEU A 115
ALA A 155
SER A 153
LEU A 149
 ILE  A 114 ( 0.7A)
LEU  A 115 ( 0.5A)
ALA  A 155 ( 0.0A)
SER  A 153 ( 0.0A)
LEU  A 149 ( 0.6A)
 1.29A 4m11C-5svdA:
undetectable		 4m11C-5svdA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 491
SER A 463
LEU A 466
LEU A 494
LEU A 465
 LEU  A 491 ( 0.6A)
SER  A 463 ( 0.0A)
LEU  A 466 ( 0.6A)
LEU  A 494 ( 0.6A)
LEU  A 465 ( 0.5A)
 1.46A 4or0A-5svdA:
undetectable		 4or0A-5svdA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		5 / 12 SER A 488
HIS A 523
LEU A 472
LEU A 467
LEU A 465
 SER  A 488 ( 0.0A)
HIS  A 523 ( 1.0A)
LEU  A 472 ( 0.5A)
LEU  A 467 ( 0.6A)
LEU  A 465 ( 0.5A)
 1.31A 4xumA-5svdA:
undetectable		 4xumA-5svdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 213
PHE A 258
SER A 257
PHE A 126
GLY A 131
 LEU  A 213 ( 0.6A)
PHE  A 258 ( 1.3A)
SER  A 257 ( 0.0A)
PHE  A 126 ( 1.3A)
GLY  A 131 ( 0.0A)
 1.08A 5f9zB-5svdA:
undetectable		 5f9zB-5svdA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 497
LEU A 494
PHE A 490
PHE A 501
GLY A 424
 TYR  A 497 ( 1.3A)
LEU  A 494 ( 0.6A)
PHE  A 490 ( 1.3A)
PHE  A 501 ( 1.3A)
GLY  A 424 ( 0.0A)
 1.11A 5fsaA-5svdA:
undetectable		 5fsaA-5svdA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		3 / 3 SER A 295
SER A 301
PHE A 325
 SER  A 295 ( 0.0A)
SER  A 301 ( 0.0A)
PHE  A 325 ( 1.3A)
 0.90A 5mugA-5svdA:
undetectable		 5mugA-5svdA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 211
LEU A 208
ARG A 207
HIS A 204
 LEU  A 211 ( 0.6A)
LEU  A 208 ( 0.5A)
ARG  A 207 ( 0.6A)
HIS  A 204 ( 1.0A)
 0.90A 6e43A-5svdA:
1.7		 6e43A-5svdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 211
LEU A 208
ARG A 207
HIS A 204
 LEU  A 211 ( 0.6A)
LEU  A 208 ( 0.5A)
ARG  A 207 ( 0.6A)
HIS  A 204 ( 1.0A)
 0.92A 6e43B-5svdA:
3.3		 6e43B-5svdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 211
LEU A 208
ARG A 207
HIS A 204
 LEU  A 211 ( 0.6A)
LEU  A 208 ( 0.5A)
ARG  A 207 ( 0.6A)
HIS  A 204 ( 1.0A)
 0.85A 6e43D-5svdA:
1.9		 6e43D-5svdA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 348
LEU A 352
PHE A 291
PHE A 273
 GLY  A 348 ( 0.0A)
LEU  A 352 ( 0.6A)
PHE  A 291 ( 1.3A)
PHE  A 273 ( 1.3A)
 1.04A 6h7lA-5svdA:
undetectable		 6h7lA-5svdA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5svd NUCLEOLAR PROTEIN 9
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 348
LEU A 352
PHE A 291
PHE A 273
 GLY  A 348 ( 0.0A)
LEU  A 352 ( 0.6A)
PHE  A 291 ( 1.3A)
PHE  A 273 ( 1.3A)
 1.04A 6h7lB-5svdA:
undetectable		 6h7lB-5svdA:
10.44