SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5swc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLY A 181
ALA A 152
TYR A 194
GLU A 153
 None
 1.04A 1dmaB-5swcA:
undetectable		 1dmaB-5swcA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		5 / 8 CYH A  39
ASP A  41
HIS A  98
CYH A 101
GLY A 102
 ZN  A 301 (-2.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.3A)
None
 0.18A 1ekjA-5swcA:
24.6
1ekjB-5swcA:
24.2		 1ekjA-5swcA:
29.51
1ekjB-5swcA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		5 / 8 CYH A  39
ASP A  41
HIS A  98
CYH A 101
GLY A 102
 ZN  A 301 (-2.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.3A)
None
 0.26A 1ekjA-5swcA:
24.6
1ekjB-5swcA:
24.2		 1ekjA-5swcA:
29.51
1ekjB-5swcA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 CYH A  39
ASP A  41
HIS A  98
GLY A 102
 ZN  A 301 (-2.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.3A)
None
 0.17A 1ekjE-5swcA:
24.1
1ekjF-5swcA:
23.8		 1ekjE-5swcA:
29.51
1ekjF-5swcA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		5 / 8 CYH A  39
ASP A  41
HIS A  98
CYH A 101
GLY A 102
 ZN  A 301 (-2.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.3A)
None
 0.15A 1ekjG-5swcA:
24.3
1ekjH-5swcA:
25.2		 1ekjG-5swcA:
29.51
1ekjH-5swcA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 CYH A  39
ASP A  41
HIS A  98
CYH A 101
 ZN  A 301 (-2.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.3A)
 0.16A 1ekjG-5swcA:
24.3
1ekjH-5swcA:
25.2		 1ekjG-5swcA:
29.51
1ekjH-5swcA:
29.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		5 / 10 ILE A  93
LEU A 124
THR A 127
ILE A  34
GLY A  97
 None
 1.20A 2v0mA-5swcA:
undetectable		 2v0mA-5swcA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_1
(CARBONIC ANHYDRASE)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		6 / 10 CYH A  39
ASP A  41
HIS A  98
CYH A 101
GLY A 102
ALA A 103
 ZN  A 301 (-2.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.3A)
None
None
 0.31A 3ucjA-5swcA:
22.1		 3ucjA-5swcA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLN A  30
PHE A  58
TYR A  83
 FMT  A 304 (-3.8A)
FMT  A 304 (-4.6A)
FMT  A 304 (-3.4A)
 0.26A 3ucjB-5swcA:
22.7		 3ucjB-5swcA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 GLN A  30
PHE A  58
TYR A  83
 FMT  A 304 (-3.8A)
FMT  A 304 (-4.6A)
FMT  A 304 (-3.4A)
 0.25A 3ucjA-5swcA:
22.0		 3ucjA-5swcA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_2
(CARBONIC ANHYDRASE)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		6 / 10 CYH A  39
ASP A  41
HIS A  98
CYH A 101
GLY A 102
ALA A 103
 ZN  A 301 (-2.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.3A)
ZN  A 301 (-2.3A)
None
None
 0.33A 3ucjB-5swcA:
22.7		 3ucjB-5swcA:
28.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 GLY A 181
ALA A 152
TYR A 194
GLU A 153
 None
 0.92A 4hyfA-5swcA:
undetectable		 4hyfA-5swcA:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		4 / 5 THR A 127
THR A 130
HIS A  98
ASN A  62
 None
None
ZN  A 301 (-3.3A)
None
 1.30A 4pgfB-5swcA:
undetectable		 4pgfB-5swcA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 5swc CARBONIC ANHYDRASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ILE A  34
LEU A 211
ALA A 210
LEU A 159
 None
 0.74A 5y7pE-5swcA:
undetectable		 5y7pE-5swcA:
19.10