SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5swi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 11 PRO B 343
ASP B 289
HIS B 287
PHE B 276
ASP B 338
 None
 1.47A 1c3sA-5swiB:
undetectable		 1c3sA-5swiB:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN B  36
PHE B  38
VAL B  31
GLY B  30
 None
 0.80A 1e7bB-5swiB:
undetectable		 1e7bB-5swiB:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 THR B 214
ALA B 182
THR B 208
LEU B 134
LEU B 146
 None
 1.34A 1eiiA-5swiB:
1.0		 1eiiA-5swiB:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 GLN B 452
TYR B 454
VAL B 499
GLY B 505
 None
None
GOL  B 704 (-4.4A)
None
 1.26A 1ekjC-5swiB:
undetectable
1ekjD-5swiB:
undetectable		 1ekjC-5swiB:
14.74
1ekjD-5swiB:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 4 ARG B 311
ALA B 606
SER B 603
TYR B 616
 GOL  B 704 (-3.0A)
None
None
None
 1.49A 1j36A-5swiB:
0.0		 1j36A-5swiB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 4 ARG B 311
ALA B 606
SER B 603
TYR B 616
 GOL  B 704 (-3.0A)
None
None
None
 1.49A 1j36B-5swiB:
0.0		 1j36B-5swiB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 TYR B 519
PHE B 458
LEU B 422
VAL B 418
ALA B 492
 None
 1.42A 1q23D-5swiB:
undetectable
1q23E-5swiB:
undetectable		 1q23D-5swiB:
15.20
1q23E-5swiB:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 TRP B 242
VAL B  31
PRO B  32
 None
 0.86A 1rg1A-5swiB:
undetectable		 1rg1A-5swiB:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 TRP B 242
VAL B  31
PRO B  32
 None
 0.84A 1rh0A-5swiB:
undetectable		 1rh0A-5swiB:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 4 LEU B 684
ILE B 320
ARG B 248
TYR B 625
 None
 1.35A 1rk3A-5swiB:
undetectable		 1rk3A-5swiB:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_B_ADNB1502_1
(CLASS B ACID
PHOSPHATASE)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 PHE B 516
LEU B 506
THR B 515
TYR B 519
 None
 1.19A 1rmtB-5swiB:
undetectable		 1rmtB-5swiB:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 TRP B 483
TYR B 535
GLY B 597
SER B  21
 None
 1.10A 2a3cB-5swiB:
undetectable		 2a3cB-5swiB:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 LEU B 212
GLY B  34
PRO B 125
ALA B 130
 None
 0.91A 2aohA-5swiB:
undetectable		 2aohA-5swiB:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 9 LEU B  63
THR B 214
ALA B 213
LEU B 123
LEU B 226
 None
 1.31A 2npnA-5swiB:
undetectable		 2npnA-5swiB:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 LEU B 342
PRO B 343
LEU B 359
ILE B 363
 None
 0.53A 2qd4A-5swiB:
undetectable		 2qd4A-5swiB:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 10 TYR B 625
ILE B 673
LEU B 646
VAL B 637
LEU B 639
 None
 1.46A 2w98A-5swiB:
undetectable		 2w98A-5swiB:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 LEU B 684
ILE B 320
ARG B 248
TYR B 625
 None
 1.34A 2zlcA-5swiB:
undetectable		 2zlcA-5swiB:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASP B 158
LEU B 162
ASP B 188
LEU B 190
 None
 1.24A 3bj8C-5swiB:
undetectable
3bj8D-5swiB:
undetectable		 3bj8C-5swiB:
13.42
3bj8D-5swiB:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 ILE B 224
SER B 220
PHE B 180
PRO B 219
 None
 1.21A 3bjwC-5swiB:
undetectable		 3bjwC-5swiB:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 TYR B 638
GLU B 323
ASP B 374
 None
 0.78A 3bxoA-5swiB:
2.6		 3bxoA-5swiB:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 TYR B 638
GLU B 323
ASP B 374
 None
 0.81A 3bxoB-5swiB:
3.6		 3bxoB-5swiB:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 GLU B 489
GLU B 541
TRP B 483
 BMA  B 706 (-4.3A)
BMA  B 706 ( 2.8A)
None
 1.32A 3hrdA-5swiB:
undetectable
3hrdE-5swiB:
undetectable
3hrdF-5swiB:
undetectable		 3hrdA-5swiB:
19.22
3hrdE-5swiB:
19.22
3hrdF-5swiB:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 SER B 624
ASP B 626
ASP B 677
 None
 0.84A 3iv6C-5swiB:
undetectable		 3iv6C-5swiB:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 9 GLY B 298
PHE B 317
PHE B 314
PHE B 301
PHE B 332
 None
 1.43A 3ko0A-5swiB:
undetectable
3ko0C-5swiB:
undetectable		 3ko0A-5swiB:
10.84
3ko0C-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 GLY B 298
PHE B 314
PHE B 301
PHE B 332
 None
 0.95A 3ko0B-5swiB:
undetectable
3ko0J-5swiB:
undetectable		 3ko0B-5swiB:
10.84
3ko0J-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 9 PHE B 301
PHE B 332
GLY B 298
PHE B 317
PHE B 314
 None
 1.38A 3ko0A-5swiB:
undetectable
3ko0C-5swiB:
undetectable		 3ko0A-5swiB:
10.84
3ko0C-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 8 GLY B 298
PHE B 317
PHE B 314
PHE B 301
PHE B 332
 None
 1.37A 3ko0D-5swiB:
undetectable
3ko0E-5swiB:
undetectable		 3ko0D-5swiB:
10.84
3ko0E-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 GLY B 361
PHE B 270
PHE B  33
PHE B 328
 None
 1.07A 3ko0D-5swiB:
undetectable
3ko0E-5swiB:
undetectable		 3ko0D-5swiB:
10.84
3ko0E-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 PHE B 301
PHE B 332
PHE B 317
PHE B 314
 None
 1.06A 3ko0D-5swiB:
undetectable
3ko0E-5swiB:
undetectable		 3ko0D-5swiB:
10.84
3ko0E-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 PHE B 301
GLY B 331
PHE B 332
PHE B 314
 None
 0.99A 3ko0D-5swiB:
undetectable
3ko0E-5swiB:
undetectable		 3ko0D-5swiB:
10.84
3ko0E-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 PHE B 301
PHE B 332
PHE B 317
PHE B 314
 None
 1.06A 3ko0D-5swiB:
undetectable
3ko0E-5swiB:
undetectable		 3ko0D-5swiB:
10.84
3ko0E-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 PHE B 317
PHE B 314
PHE B 301
PHE B 332
 None
 1.12A 3ko0D-5swiB:
undetectable
3ko0E-5swiB:
undetectable		 3ko0D-5swiB:
10.84
3ko0E-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 PHE B 301
PHE B 332
PHE B 317
PHE B 314
 None
 1.08A 3ko0F-5swiB:
undetectable
3ko0G-5swiB:
0.0		 3ko0F-5swiB:
10.84
3ko0G-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 PHE B 317
PHE B 314
PHE B 301
PHE B 332
 None
 1.02A 3ko0F-5swiB:
undetectable
3ko0G-5swiB:
0.0		 3ko0F-5swiB:
10.84
3ko0G-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 8 PHE B 301
PHE B 332
GLY B 298
PHE B 317
PHE B 314
 None
 1.32A 3ko0B-5swiB:
undetectable
3ko0J-5swiB:
undetectable		 3ko0B-5swiB:
10.84
3ko0J-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 PHE B 317
PHE B 314
PHE B 301
PHE B 332
 None
 1.09A 3ko0B-5swiB:
undetectable
3ko0J-5swiB:
undetectable		 3ko0B-5swiB:
10.84
3ko0J-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 PHE B 328
GLY B 361
PHE B 270
PHE B  33
 None
 1.05A 3ko0B-5swiB:
undetectable
3ko0J-5swiB:
undetectable		 3ko0B-5swiB:
10.84
3ko0J-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 GLY B 298
PHE B 314
PHE B 301
PHE B 332
 None
 0.78A 3ko0K-5swiB:
undetectable
3ko0S-5swiB:
undetectable		 3ko0K-5swiB:
10.84
3ko0S-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 7 GLY B 298
PHE B 317
PHE B 314
PHE B 301
PHE B 332
 None
 1.43A 3ko0L-5swiB:
undetectable
3ko0N-5swiB:
undetectable		 3ko0L-5swiB:
10.84
3ko0N-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 GLY B 361
PHE B 270
PHE B  33
PHE B 328
 None
 1.08A 3ko0L-5swiB:
undetectable
3ko0N-5swiB:
undetectable		 3ko0L-5swiB:
10.84
3ko0N-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 GLY B 298
PHE B 314
PHE B 301
PHE B 332
 None
 0.99A 3ko0O-5swiB:
undetectable
3ko0Q-5swiB:
undetectable		 3ko0O-5swiB:
10.84
3ko0Q-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 PHE B 314
PHE B 301
GLY B 331
PHE B 332
 None
 0.86A 3ko0O-5swiB:
undetectable
3ko0Q-5swiB:
undetectable		 3ko0O-5swiB:
10.84
3ko0Q-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 10 GLY B 298
PHE B 317
PHE B 314
PHE B 301
PHE B 332
 None
 1.43A 3ko0R-5swiB:
undetectable
3ko0T-5swiB:
undetectable		 3ko0R-5swiB:
10.84
3ko0T-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 10 PHE B 317
PHE B 314
PHE B 301
GLY B 331
PHE B 332
 None
 1.49A 3ko0R-5swiB:
undetectable
3ko0T-5swiB:
undetectable		 3ko0R-5swiB:
10.84
3ko0T-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 7 PHE B 301
PHE B 332
GLY B 298
PHE B 317
PHE B 314
 None
 1.34A 3ko0K-5swiB:
undetectable
3ko0S-5swiB:
undetectable		 3ko0K-5swiB:
10.84
3ko0S-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 PHE B 306
GLY B 340
PHE B 328
PHE B 314
 None
 1.07A 3ko0K-5swiB:
undetectable
3ko0S-5swiB:
undetectable		 3ko0K-5swiB:
10.84
3ko0S-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 PHE B 317
PHE B 314
PHE B 301
PHE B 332
 None
 1.09A 3ko0K-5swiB:
undetectable
3ko0S-5swiB:
undetectable		 3ko0K-5swiB:
10.84
3ko0S-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 PHE B 328
GLY B 361
PHE B 270
PHE B  33
 None
 1.06A 3ko0K-5swiB:
undetectable
3ko0S-5swiB:
undetectable		 3ko0K-5swiB:
10.84
3ko0S-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 7 PHE B 301
PHE B 332
GLY B 298
PHE B 317
PHE B 314
 None
 1.30A 3ko0R-5swiB:
undetectable
3ko0T-5swiB:
undetectable		 3ko0R-5swiB:
10.84
3ko0T-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 PHE B 317
PHE B 314
PHE B 301
PHE B 332
 None
 1.11A 3ko0R-5swiB:
undetectable
3ko0T-5swiB:
undetectable		 3ko0R-5swiB:
10.84
3ko0T-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 PHE B 328
GLY B 361
PHE B 270
PHE B  33
 None
 1.02A 3ko0R-5swiB:
undetectable
3ko0T-5swiB:
undetectable		 3ko0R-5swiB:
10.84
3ko0T-5swiB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ARG B 584
LEU B 316
ILE B 673
PHE B 615
 None
 1.07A 3ln1C-5swiB:
undetectable		 3ln1C-5swiB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 5 ARG B 584
LEU B 316
ILE B 673
PHE B 615
 None
 1.07A 3ln1D-5swiB:
undetectable		 3ln1D-5swiB:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 ASP B 360
SER B 427
ARG B 398
 None
 0.89A 3loqA-5swiB:
undetectable		 3loqA-5swiB:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 LEU B 110
LEU B 123
SER B 131
GLN B 106
LEU B   5
 None
 1.33A 3m7rA-5swiB:
undetectable		 3m7rA-5swiB:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ASN B  36
HIS B  65
LEU B  77
ASP B 150
 None
 1.28A 3oi8A-5swiB:
undetectable		 3oi8A-5swiB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OI8_A_ADNA2_1
(UNCHARACTERIZED
PROTEIN)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ILE B 362
ASN B 304
PRO B 343
LEU B 359
 None
 1.29A 3oi8A-5swiB:
undetectable		 3oi8A-5swiB:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 9 PHE B  33
PHE B 317
GLY B 602
THR B 313
PHE B 328
 None
 1.38A 3t3rC-5swiB:
undetectable		 3t3rC-5swiB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 LEU B 269
TYR B 625
TRP B 610
THR B 312
 None
 1.31A 3wipF-5swiB:
undetectable
3wipJ-5swiB:
undetectable		 3wipF-5swiB:
15.21
3wipJ-5swiB:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 THR B  14
HIS B 264
TYR B 267
PHE B  51
 None
 1.05A 4awuA-5swiB:
undetectable		 4awuA-5swiB:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B53_B_ACTB1445_0
(IG GAMMA-4 CHAIN C
REGION)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 GLU B 416
GLY B 484
SER B 419
 GOL  B 705 (-4.4A)
None
None
 0.69A 4b53B-5swiB:
undetectable		 4b53B-5swiB:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 4 LEU B 342
PRO B 343
LEU B 359
ILE B 363
 None
 0.59A 4f4dB-5swiB:
undetectable		 4f4dB-5swiB:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 GLU B 278
GLN B 284
GLY B 283
SER B 282
 None
 1.01A 4f93B-5swiB:
undetectable		 4f93B-5swiB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 MET B 383
LEU B 342
GLU B 350
ILE B 363
ILE B 362
 None
 1.17A 4j24A-5swiB:
undetectable		 4j24A-5swiB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 MET B 383
LEU B 342
GLU B 350
ILE B 363
ILE B 362
 None
 1.17A 4j24B-5swiB:
undetectable		 4j24B-5swiB:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 PHE B 276
ASP B 349
TYR B  74
LEU B 177
 None
 1.36A 4paeA-5swiB:
undetectable		 4paeA-5swiB:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.44A 4v2yA-5swiB:
undetectable		 4v2yA-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.46A 4v2yB-5swiB:
undetectable		 4v2yB-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.44A 4v2zA-5swiB:
undetectable		 4v2zA-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.45A 4v2zB-5swiB:
undetectable		 4v2zB-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.47A 4v30A-5swiB:
undetectable		 4v30A-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.41A 4v30B-5swiB:
undetectable		 4v30B-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 11 LEU B  77
LEU B 152
GLU B 155
ALA B 163
LEU B 164
 None
 1.11A 4wg0J-5swiB:
undetectable
4wg0K-5swiB:
undetectable
4wg0L-5swiB:
undetectable		 4wg0J-5swiB:
1.85
4wg0K-5swiB:
1.85
4wg0L-5swiB:
1.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 SER B 603
PHE B 317
PHE B 272
THR B  14
GLY B  13
 None
 1.48A 4zjlA-5swiB:
undetectable		 4zjlA-5swiB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.49A 5amhA-5swiB:
undetectable		 5amhA-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.45A 5amiA-5swiB:
undetectable		 5amiA-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.43A 5amiB-5swiB:
undetectable		 5amiB-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.48A 5amjA-5swiB:
undetectable		 5amjA-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.44A 5amjB-5swiB:
undetectable		 5amjB-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		5 / 12 LEU B 316
ARG B 248
TYR B 638
TYR B 625
LEU B 613
 None
 1.38A 5czyA-5swiB:
0.7		 5czyA-5swiB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 ALA B 222
ASN B 225
LEU B 226
 None
 0.34A 5i1nB-5swiB:
undetectable		 5i1nB-5swiB:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 ALA B 222
ASN B 225
LEU B 226
 None
 0.32A 5i1oC-5swiB:
undetectable		 5i1oC-5swiB:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.43A 5oh1A-5swiB:
undetectable		 5oh1A-5swiB:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.41A 5oh1B-5swiB:
undetectable		 5oh1B-5swiB:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.43A 5oh3A-5swiB:
undetectable		 5oh3A-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_B_9V2B202_0
(CEREBLON ISOFORM 4)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ASN B 304
PRO B 273
PHE B 301
TYR B  74
 None
 1.41A 5oh3B-5swiB:
undetectable		 5oh3B-5swiB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 THR B  25
TYR B  28
THR B  10
ARG B  11
 None
 1.42A 5tzoA-5swiB:
undetectable		 5tzoA-5swiB:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 8 THR B  25
TYR B  28
THR B  10
ARG B  11
 None
 1.40A 5tzoB-5swiB:
undetectable		 5tzoB-5swiB:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		3 / 3 TYR B 128
ALA B 285
TYR B 277
 None
 0.84A 5uunB-5swiB:
undetectable		 5uunB-5swiB:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 ILE B 252
ILE B 609
LEU B 613
PHE B 317
 None
 1.05A 5vkqA-5swiB:
undetectable
5vkqB-5swiB:
undetectable		 5vkqA-5swiB:
18.50
5vkqB-5swiB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 PHE B 317
ILE B 252
ILE B 609
LEU B 613
 None
 1.02A 5vkqA-5swiB:
undetectable
5vkqD-5swiB:
2.6		 5vkqA-5swiB:
18.50
5vkqD-5swiB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 6 PHE B 272
SER B 605
HIS B 264
TYR B 267
 None
 1.43A 5ycnA-5swiB:
undetectable		 5ycnA-5swiB:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_A_EY4A502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 ALA B 577
THR B 576
TYR B 575
VAL B 660
 None
 0.92A 6cduA-5swiB:
1.7
6cduE-5swiB:
2.2		 6cduA-5swiB:
17.31
6cduE-5swiB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_H_EY4H500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5swi SUGAR HYDROLASE
(Streptococcus
pneumoniae) 		4 / 7 VAL B 660
ALA B 577
THR B 576
TYR B 575
 None
 0.86A 6cduH-5swiB:
2.2
6cduI-5swiB:
2.1		 6cduH-5swiB:
17.31
6cduI-5swiB:
17.31