SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5swj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 11 LEU A 408
SER A 145
LEU A 146
VAL A 404
ILE A 429
 None
 1.37A 1ee2A-5swjA:
undetectable		 1ee2A-5swjA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 TYR A 418
GLU A 419
PHE A 367
LEU A 371
PHE A 407
 None
 1.33A 1nw3A-5swjA:
undetectable		 1nw3A-5swjA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		3 / 3 ASP A 249
THR A 252
GLU A 307
 None
 0.77A 1pj7A-5swjA:
undetectable		 1pj7A-5swjA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TH6_A_OINA401_1
(PHOSPHOLIPASE A2)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		4 / 7 GLY A 190
ASP A 217
TYR A 218
PRO A  98
 None
 0.96A 1th6A-5swjA:
undetectable		 1th6A-5swjA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ARM_A_OINA401_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		4 / 7 GLY A 190
ASP A 217
TYR A 218
PRO A  98
 None
 0.96A 2armA-5swjA:
undetectable		 2armA-5swjA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBN_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		4 / 7 PHE A 106
THR A 109
VAL A 102
VAL A  96
 None
 0.93A 2qbnA-5swjA:
undetectable		 2qbnA-5swjA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 THR A 138
ILE A 140
GLY A 139
PHE A 407
PRO A 340
 None
 1.31A 2y7kC-5swjA:
1.4		 2y7kC-5swjA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 10 THR A 138
ILE A 140
GLY A 139
PHE A 407
PRO A 340
 None
 1.50A 2y7pA-5swjA:
undetectable		 2y7pA-5swjA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		3 / 3 ARG A 368
ILE A 327
THR A 299
 None
 0.73A 3ia4D-5swjA:
undetectable		 3ia4D-5swjA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		4 / 7 GLY A 139
GLY A 177
PHE A 167
PHE A 339
 None
 0.71A 3ko0M-5swjA:
undetectable
3ko0P-5swjA:
undetectable		 3ko0M-5swjA:
14.41
3ko0P-5swjA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 ILE A 140
ASP A 144
THR A 138
ILE A 327
PRO A 340
 None
 1.10A 3kpbA-5swjA:
undetectable		 3kpbA-5swjA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 ILE A 140
ASP A 144
THR A 138
SER A 344
PRO A 340
 None
 1.20A 3kpbA-5swjA:
undetectable		 3kpbA-5swjA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 ILE A 140
ASP A 144
THR A 138
ILE A 327
PRO A 340
 None
 1.12A 3kpbC-5swjA:
undetectable		 3kpbC-5swjA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 ILE A 140
ASP A 144
THR A 138
ILE A 327
PRO A 340
 None
 1.14A 3kpdB-5swjA:
undetectable		 3kpdB-5swjA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		4 / 7 GLU A 375
LEU A 333
LYS A 336
ARG A 378
 None
 1.20A 3mbgA-5swjA:
undetectable
3mbgB-5swjA:
undetectable		 3mbgA-5swjA:
17.30
3mbgB-5swjA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 LEU A  91
ILE A 229
ALA A 232
ILE A 298
ALA A 300
 None
 0.92A 3nxuA-5swjA:
undetectable		 3nxuA-5swjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 LEU A  91
ILE A 229
ALA A 232
ILE A 298
ALA A 300
 None
 0.91A 3nxuB-5swjA:
undetectable		 3nxuB-5swjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 LEU A 172
GLY A 177
ALA A 178
ASP A 179
ILE A 180
 None
 0.88A 3ogqB-5swjA:
undetectable		 3ogqB-5swjA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 10 LEU A 285
ARG A 154
PRO A 289
ALA A 245
LEU A 323
 None
 1.27A 4la0A-5swjA:
undetectable		 4la0A-5swjA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 ASP A 357
HIS A 360
ALA A 364
GLN A 153
LEU A 147
 None
 1.43A 5syfB-5swjA:
undetectable		 5syfB-5swjA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 LEU A 263
ASP A 260
VAL A 261
SER A 220
LEU A 315
 None
 1.18A 5tudA-5swjA:
2.6		 5tudA-5swjA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 LEU A  91
ILE A 229
ALA A 232
ILE A 298
ALA A 300
 None
 0.91A 5vc0A-5swjA:
undetectable		 5vc0A-5swjA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 5swj PROBABLE ATP
SYNTHASE SPAL/MXIB
(Shigella
flexneri) 		5 / 12 GLY A 150
ASP A 249
ILE A 248
SER A 349
VAL A 351
 None
 1.12A 6mhtA-5swjA:
undetectable		 6mhtA-5swjA:
22.11