SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5swk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 5swk E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		5 / 10 ILE A  61
GLY A  58
ILE A 103
LEU A  34
PHE A  86
 None
 1.14A 1z11C-5swkA:
undetectable		 1z11C-5swkA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5swk E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		4 / 8 PHE A  86
LEU A  54
GLY A  58
VAL A  75
 None
 0.91A 2a1oA-5swkA:
undetectable		 2a1oA-5swkA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5swk DE NOVO PROTEIN
BASED ON THE
INHIBITOR
AMOEBIASIN-1
(Entamoeba
histolytica) 		4 / 7 TYR C  82
TYR C  64
GLY C  31
TYR C  48
 None
 1.09A 2g70B-5swkC:
undetectable		 2g70B-5swkC:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5swk DE NOVO PROTEIN
BASED ON THE
INHIBITOR
AMOEBIASIN-1
(Entamoeba
histolytica) 		4 / 7 TYR C  82
TYR C  64
GLY C  31
TYR C  48
 None
 1.09A 2g72B-5swkC:
undetectable		 2g72B-5swkC:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5swk DE NOVO PROTEIN
BASED ON THE
INHIBITOR
AMOEBIASIN-1
E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Entamoeba
histolytica;
Homo
sapiens) 		4 / 5 GLN A  72
THR C  85
HIS A  96
LEU C  94
 None
 1.10A 2zj0A-5swkA:
undetectable		 2zj0A-5swkA:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TPX_C_ACTC207_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 5swk E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		4 / 4 LYS A  31
PRO A  32
LEU A  33
ASN A 106
 None
 0.86A 3tpxC-5swkA:
17.5		 3tpxC-5swkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5swk DE NOVO PROTEIN
BASED ON THE
INHIBITOR
AMOEBIASIN-1
E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Entamoeba
histolytica;
Homo
sapiens) 		4 / 5 GLN A  72
THR C  85
HIS A  96
LEU C  94
 None
 1.01A 4lvcA-5swkA:
undetectable		 4lvcA-5swkA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5swk DE NOVO PROTEIN
BASED ON THE
INHIBITOR
AMOEBIASIN-1
E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Entamoeba
histolytica;
Homo
sapiens) 		4 / 5 GLN A  72
THR C  85
HIS A  96
LEU C  94
 None
 1.02A 4lvcC-5swkA:
undetectable		 4lvcC-5swkA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 5swk E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		4 / 6 LEU A 107
LEU A  38
LEU A  35
LEU A  85
 None
 1.00A 5gs4A-5swkA:
undetectable		 5gs4A-5swkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_2
(-)		 5swk DE NOVO PROTEIN
BASED ON THE
INHIBITOR
AMOEBIASIN-1
E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Entamoeba
histolytica;
Homo
sapiens) 		4 / 4 GLN A  72
THR C  85
HIS A  96
LEU C  94
 None
 0.99A 6f3nB-5swkA:
undetectable		 6f3nB-5swkA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 5swk DE NOVO PROTEIN
BASED ON THE
INHIBITOR
AMOEBIASIN-1
E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Entamoeba
histolytica;
Homo
sapiens) 		4 / 5 GLN A  72
THR C  85
HIS A  96
LEU C  94
 None
 0.98A 6gbnA-5swkA:
undetectable		 6gbnA-5swkA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 5swk DE NOVO PROTEIN
BASED ON THE
INHIBITOR
AMOEBIASIN-1
E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Entamoeba
histolytica;
Homo
sapiens) 		4 / 5 GLN A  72
THR C  85
HIS A  96
LEU C  94
 None
 0.98A 6gbnD-5swkA:
undetectable		 6gbnD-5swkA:
16.06