SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5swn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_A_RIOA500_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 9 ASP A 218
GLY A  39
SER A 116
ASP A 230
ASP A 226
 None
 1.34A 1m4gA-5swnA:
1.0		 1m4gA-5swnA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 9 ASP A 218
GLY A  39
SER A 116
ASP A 230
ASP A 226
 None
 1.35A 1m4gB-5swnA:
undetectable		 1m4gB-5swnA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		3 / 3 TRP A  15
PHE A  24
TRP A  70
 None
 1.32A 1r15C-5swnA:
undetectable		 1r15C-5swnA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		3 / 3 TRP A  15
PHE A  24
TRP A  70
 None
 1.32A 1r15F-5swnA:
undetectable		 1r15F-5swnA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		3 / 3 TRP A  15
PHE A  24
TRP A  70
 None
 1.33A 1r15G-5swnA:
undetectable		 1r15G-5swnA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		3 / 3 TRP A  15
PHE A  24
TRP A  70
 None
 1.32A 1r15H-5swnA:
undetectable		 1r15H-5swnA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		4 / 8 TYR A 219
ASP A 218
TRP A 156
HIS A 229
 FAH  A 401 (-4.5A)
None
FAH  A 401 (-4.2A)
None
 1.17A 2ha2A-5swnA:
12.9		 2ha2A-5swnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		4 / 8 TYR A 219
ASP A 218
TRP A 156
HIS A 229
 FAH  A 401 (-4.5A)
None
FAH  A 401 (-4.2A)
None
 1.18A 2ha2B-5swnA:
12.7		 2ha2B-5swnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		4 / 7 MET A 215
ARG A 203
PRO A 166
GLY A 171
 None
 1.04A 2pnjB-5swnA:
2.9		 2pnjB-5swnA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 8 MET A  96
PRO A  66
SER A  71
VAL A 115
GLY A 112
 None
 1.39A 2qd3A-5swnA:
3.0		 2qd3A-5swnA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		3 / 3 TRP A 185
GLN A 255
TRP A 142
 None
 0.80A 2vqyA-5swnA:
undetectable		 2vqyA-5swnA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		4 / 4 VAL A 115
PHE A 104
VAL A  62
TRP A  47
 None
 1.19A 2y00A-5swnA:
0.0		 2y00A-5swnA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA2_0
(FERROCHELATASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		4 / 6 MET A 215
ARG A 203
PRO A 166
GLY A 171
 None
 1.18A 3aqiA-5swnA:
2.8		 3aqiA-5swnA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		4 / 5 HIS A 109
TYR A  68
ARG A 111
GLY A 112
 None
None
FAH  A 401 (-3.8A)
None
 1.00A 3b9mA-5swnA:
undetectable		 3b9mA-5swnA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 12 GLY A 112
ASN A 110
GLY A  39
LEU A  35
PHE A 104
 None
FAH  A 401 (-3.3A)
None
None
None
 0.93A 3ihtA-5swnA:
undetectable		 3ihtA-5swnA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		3 / 3 ALA A 207
ARG A 203
LYS A 179
 None
 1.04A 3kp5B-5swnA:
undetectable		 3kp5B-5swnA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		4 / 6 ALA A 205
HIS A 201
VAL A  45
HIS A  44
 None
 1.16A 3nneG-5swnA:
undetectable		 3nneG-5swnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A   4
ASP A  64
GLY A  69
ALA A 205
ALA A 207
 None
 1.18A 3p5nA-5swnA:
undetectable		 3p5nA-5swnA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 9 GLY A 273
TRP A 264
ALA A 254
ASP A 134
LEU A 133
 None
None
CL  A 402 ( 4.5A)
None
None
 1.38A 3ur0C-5swnA:
undetectable		 3ur0C-5swnA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 12 TYR A 177
LEU A 170
PHE A  40
ALA A 150
TYR A 154
 None
 0.85A 3vw7A-5swnA:
undetectable		 3vw7A-5swnA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_A_SFYA807_0
(SEPIAPTERIN
REDUCTASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 11 SER A 116
LEU A 119
PHE A 104
ALA A  63
MET A  96
 None
 1.34A 4hwkA-5swnA:
2.2		 4hwkA-5swnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 12 LEU A  65
MET A  46
TRP A 185
PHE A 281
VAL A  50
 None
 1.23A 4ib4A-5swnA:
undetectable		 4ib4A-5swnA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 12 SER A 116
LEU A 119
PHE A 104
ALA A  63
MET A  96
 None
 1.23A 4j7xA-5swnA:
undetectable		 4j7xA-5swnA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 12 GLN A  91
ALA A  89
VAL A 115
LEU A  37
ILE A  23
 None
 1.22A 4pd9A-5swnA:
undetectable		 4pd9A-5swnA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		4 / 8 LEU A 106
LEU A  65
GLY A 112
ALA A 113
 None
 0.58A 5f1aA-5swnA:
undetectable		 5f1aA-5swnA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		3 / 3 TYR A 117
SER A 116
TRP A 264
 None
 0.95A 5n8jB-5swnA:
undetectable		 5n8jB-5swnA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		3 / 3 TYR A 117
SER A 116
TRP A 264
 None
 0.93A 5n8jA-5swnA:
undetectable		 5n8jA-5swnA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		3 / 3 TYR A 117
SER A 116
TRP A 264
 None
 0.98A 5n8jD-5swnA:
undetectable		 5n8jD-5swnA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 5swn FLUOROACETATE
DEHALOGENASE
(Rhodopseudomonas
palustris) 		5 / 12 ALA A 120
GLY A 125
GLY A 108
LEU A  65
LEU A  37
 None
 1.14A 5wwsA-5swnA:
undetectable		 5wwsA-5swnA:
20.25