SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5swu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Aspergillus
fumigatus) 		5 / 10 ASP A1131
ILE A1095
GLY A1094
GLY A1127
ARG A1121
 None
 1.08A 1mehA-5swuA:
4.5		 1mehA-5swuA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Aspergillus
fumigatus) 		4 / 5 ARG A1121
ASP A1153
ILE A1117
LYS A1208
 None
 1.45A 2xrzA-5swuA:
undetectable
2xrzB-5swuA:
undetectable		 2xrzA-5swuA:
20.21
2xrzB-5swuA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Aspergillus
fumigatus) 		4 / 8 ASN A1241
MET A1285
LEU A1252
ILE A1238
 None
 0.94A 4ok1A-5swuA:
undetectable		 4ok1A-5swuA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Aspergillus
fumigatus) 		3 / 3 VAL A1152
TYR A1141
ALA A1144
 None
 0.34A 4ybnA-5swuA:
undetectable		 4ybnA-5swuA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Aspergillus
fumigatus) 		3 / 3 THR A1122
GLU A1155
HIS A1179
 None
 0.62A 5xioA-5swuA:
undetectable		 5xioA-5swuA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Aspergillus
fumigatus) 		3 / 3 THR A1122
GLU A1155
HIS A1179
 None
 0.64A 5xiqB-5swuA:
undetectable		 5xiqB-5swuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Aspergillus
fumigatus) 		3 / 3 THR A1122
GLU A1155
HIS A1179
 None
 0.57A 5xiqD-5swuA:
undetectable		 5xiqD-5swuA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Aspergillus
fumigatus) 		5 / 12 PHE A1255
ILE A1288
GLY A1254
SER A1052
PHE A1053
 None
 1.00A 6c2mA-5swuA:
undetectable		 6c2mA-5swuA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5swu PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Aspergillus
fumigatus) 		5 / 12 PHE A1255
ILE A1288
GLY A1254
SER A1052
PHE A1053
 None
 1.02A 6c2mB-5swuA:
undetectable		 6c2mB-5swuA:
16.13