SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5swv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		5 / 10 GLY C1423
LEU C1443
ASN C1445
THR C1425
GLY C1424
 None
 1.32A 1kvlA-5swvC:
undetectable		 1kvlA-5swvC:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		5 / 9 ARG C1229
LEU C1225
GLU C1226
PHE C1243
GLY C1274
 None
 1.40A 1mjlA-5swvC:
undetectable
1mjlB-5swvC:
undetectable		 1mjlA-5swvC:
12.26
1mjlB-5swvC:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		5 / 11 MET C1236
VAL C1209
ALA C1207
SER C1180
ASP C1155
 None
 1.44A 2c12B-5swvC:
undetectable		 2c12B-5swvC:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_D_SPMD1434_1
(NITROALKANE OXIDASE)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		5 / 10 MET C1236
VAL C1209
ALA C1207
SER C1180
ASP C1155
 None
 1.41A 2c12D-5swvC:
undetectable		 2c12D-5swvC:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		5 / 11 MET C1236
LEU C1240
ALA C1203
SER C1180
ASP C1155
 None
 1.24A 2c12F-5swvC:
undetectable		 2c12F-5swvC:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		5 / 11 MET C1236
LEU C1240
ALA C1207
SER C1180
ASP C1155
 None
 1.24A 2c12F-5swvC:
undetectable		 2c12F-5swvC:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		5 / 12 SER C1487
LEU C1407
LEU C1482
GLY C1417
ALA C1511
 None
 1.17A 2kceB-5swvC:
undetectable		 2kceB-5swvC:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		4 / 7 LYS C1498
ASP C1470
ASP C1468
ARG C1446
 None
 1.45A 2pk4A-5swvC:
undetectable		 2pk4A-5swvC:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		3 / 3 GLY C1550
SER C1553
TRP C1557
 None
 0.87A 4e7cD-5swvC:
0.9		 4e7cD-5swvC:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP C1395
ALA C1369
THR C1394
THR C1377
 None
 1.46A 4w5qA-5swvC:
undetectable		 4w5qA-5swvC:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP C1395
ALA C1369
THR C1394
THR C1377
 None
 1.49A 4w5rA-5swvC:
undetectable		 4w5rA-5swvC:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP C1395
ALA C1369
THR C1394
THR C1377
 None
 1.45A 4w5tA-5swvC:
undetectable		 4w5tA-5swvC:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_2
(TUBULIN BETA CHAIN)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		5 / 11 LYS C1338
LEU C1340
ALA C1348
VAL C1350
ILE C1378
 None
 0.84A 4x20D-5swvC:
undetectable		 4x20D-5swvC:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP C1395
ALA C1369
THR C1394
THR C1377
 None
 1.44A 4z4cA-5swvC:
undetectable		 4z4cA-5swvC:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP C1395
ALA C1369
THR C1394
THR C1377
 None
 1.46A 4z4fA-5swvC:
undetectable		 4z4fA-5swvC:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		4 / 5 ASP C1395
ALA C1369
THR C1394
THR C1377
 None
 1.45A 4z4gA-5swvC:
undetectable		 4z4gA-5swvC:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		5 / 11 LEU C1517
ALA C1484
LEU C1436
LEU C1433
LEU C1407
 None
 1.28A 4zn7B-5swvC:
undetectable		 4zn7B-5swvC:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		4 / 5 GLU C1227
ALA C1191
GLU C1224
ASN C1220
 None
 1.15A 5dwkC-5swvC:
undetectable		 5dwkC-5swvC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		4 / 5 ILE C1430
GLY C1417
ILE C1464
LEU C1433
 None
 0.89A 5dzki-5swvC:
1.7
5dzkj-5swvC:
1.7
5dzkx-5swvC:
undetectable		 5dzki-5swvC:
17.84
5dzkj-5swvC:
17.84
5dzkx-5swvC:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		4 / 5 ILE C1430
GLY C1417
ILE C1464
LEU C1433
 None
 0.86A 5dzkd-5swvC:
undetectable
5dzkk-5swvC:
1.7
5dzky-5swvC:
undetectable		 5dzkd-5swvC:
19.04
5dzkk-5swvC:
17.84
5dzky-5swvC:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		5 / 11 ILE C1241
PHE C1243
ASP C1155
THR C1121
VAL C1262
 None
 1.41A 5jkwA-5swvC:
undetectable		 5jkwA-5swvC:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE
(Schizosaccharomy
ces
pombe) 		4 / 6 SER C1180
ARG C1084
THR C1058
ALA C1272
 None
None
None
PGE  C1601 ( 4.4A)
 0.99A 6ma6A-5swvC:
undetectable		 6ma6A-5swvC:
8.92