SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5sx4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 5 VAL M 417
SER M 440
ASP M 436
GLN M 408
 None
 1.14A 1n2xB-5sx4M:
undetectable		 1n2xB-5sx4M:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		4 / 8 GLY M 315
GLY M 343
GLY M 379
ILE M 402
 None
 0.66A 3d41A-5sx4M:
undetectable		 3d41A-5sx4M:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_1
(FIV PROTEASE)		 5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 10 LEU M 368
VAL M 374
GLY M 315
ILE M 316
LEU M 371
 None
 0.87A 3ogqA-5sx4M:
undetectable		 3ogqA-5sx4M:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 TRP M 386
LEU M 368
LEU M 345
ILE M 383
ILE M 327
 None
 1.48A 4a79A-5sx4M:
undetectable		 4a79A-5sx4M:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5sx4 PANITUMUMAB FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 4 TYR J  61
THR J  59
GLY J  51
LEU J  82
 None
 1.34A 4w5nA-5sx4J:
undetectable		 4w5nA-5sx4J:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 ARG M 427
ASN M 398
ASP M 369
 None
 0.79A 5gwxA-5sx4M:
undetectable		 5gwxA-5sx4M:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		3 / 3 GLN M 462
THR M 459
ASP M 434
 None
 0.89A 5k9dA-5sx4M:
undetectable		 5k9dA-5sx4M:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 SER M 326
ILE M 327
PHE M 396
ALA M 385
ALA M 415
 None
 1.12A 5vcgA-5sx4M:
undetectable		 5vcgA-5sx4M:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens) 		5 / 12 ILE M 421
LEU M 371
LEU M 348
PRO M 349
LEU M 419
 None
 1.28A 5xxiA-5sx4M:
undetectable		 5xxiA-5sx4M:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5sx4 PANITUMUMAB FAB
HEAVY CHAIN
EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens;
Homo
sapiens) 		5 / 11 ASP J 100
GLY M 471
SER M 474
ALA M 477
ASN J  60
 None
 1.32A 6hu9A-5sx4J:
undetectable
6hu9E-5sx4J:
undetectable
6hu9I-5sx4J:
undetectable		 6hu9A-5sx4J:
22.83
6hu9E-5sx4J:
20.50
6hu9I-5sx4J:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5sx4 PANITUMUMAB FAB
HEAVY CHAIN
EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens;
Homo
sapiens) 		5 / 10 ASP J 100
GLY M 471
SER M 474
ALA M 477
ASN J  60
 None
 1.28A 6hu9L-5sx4J:
undetectable
6hu9P-5sx4J:
undetectable
6hu9T-5sx4J:
undetectable		 6hu9L-5sx4J:
22.83
6hu9P-5sx4J:
20.50
6hu9T-5sx4J:
13.96