SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5sxg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)
5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo
sapiens)
3 / 3 THR A 197
PRO A 195
THR A 199
None
0.68A 209dC-5sxgA:
undetectable
209dC-5sxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)
5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo
sapiens)
4 / 7 LEU A 259
VAL A 275
LEU A 216
LEU A 377
None
0.94A 3g8iA-5sxgA:
undetectable
3g8iA-5sxgA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)
5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo
sapiens)
4 / 7 PHE A 341
PHE A 198
GLY A 361
PHE A 278
None
None
None
IMD  A 403 ( 4.7A)
0.87A 3ko0R-5sxgA:
undetectable
3ko0T-5sxgA:
undetectable
3ko0R-5sxgA:
20.79
3ko0T-5sxgA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)
5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo
sapiens)
4 / 7 ASP A 346
GLN A 352
PRO A 355
GLN A 357
None
1.05A 3l2vA-5sxgA:
undetectable
3l2vA-5sxgA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo
sapiens)
4 / 6 GLU A 342
TYR A 338
LEU A 362
PHE A 356
None
1.25A 4twdI-5sxgA:
undetectable
4twdJ-5sxgA:
undetectable
4twdI-5sxgA:
13.42
4twdJ-5sxgA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)
5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo
sapiens)
3 / 3 ARG A 351
ASP A 346
TRP A 345
None
0.93A 4xdqA-5sxgA:
undetectable
4xdqA-5sxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)
5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo
sapiens)
5 / 12 LEU A 362
GLY A 361
ASN A 204
PHE A 202
TYR A 338
None
1.24A 5czyA-5sxgA:
undetectable
5czyA-5sxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)
5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B

(Homo
sapiens)
4 / 5 LEU A 261
TYR A 218
MET A 235
ASP A 232
None
1.30A 5p9iA-5sxgA:
undetectable
5p9iA-5sxgA:
16.12