SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5sy1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 5sy1 STRA6
(Danio
rerio) 		5 / 12 LEU A 360
LEU A 357
ASN A 356
LEU A 354
MET A 414
 None
 1.41A 1a28B-5sy1A:
undetectable		 1a28B-5sy1A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 5sy1 STRA6
(Danio
rerio) 		5 / 9 LEU A 134
ILE A  44
PHE A 113
LEU A 111
GLY A  38
 None
 1.16A 1e7aB-5sy1A:
undetectable		 1e7aB-5sy1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 5sy1 STRA6
(Danio
rerio) 		4 / 6 TYR A 200
TYR A 150
HIS A 145
VAL A  78
 None
 1.41A 1q13A-5sy1A:
undetectable		 1q13A-5sy1A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_B_NCAB508_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5sy1 STRA6
(Danio
rerio) 		4 / 5 GLN A 288
LEU A 291
TYR A 181
GLN A 176
 None
 1.33A 1yc2B-5sy1A:
undetectable
1yc2C-5sy1A:
undetectable		 1yc2B-5sy1A:
15.84
1yc2C-5sy1A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_A_J01A1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5sy1 STRA6
(Danio
rerio) 		5 / 12 LEU A 138
ILE A  44
TYR A 135
THR A 159
LEU A 193
 None
 1.03A 2japA-5sy1A:
undetectable		 2japA-5sy1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5sy1 STRA6
(Danio
rerio) 		5 / 12 LEU A 138
ILE A  44
TYR A 135
THR A 159
LEU A 193
 None
 1.03A 2japB-5sy1A:
undetectable		 2japB-5sy1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5sy1 STRA6
(Danio
rerio) 		5 / 12 LEU A 138
ILE A  44
TYR A 135
THR A 159
LEU A 193
 None
 1.02A 2japC-5sy1A:
undetectable		 2japC-5sy1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 5sy1 STRA6
(Danio
rerio) 		5 / 12 LEU A 138
ILE A  44
TYR A 135
THR A 159
LEU A 193
 None
 1.01A 2japD-5sy1A:
undetectable		 2japD-5sy1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5sy1 STRA6
(Danio
rerio) 		4 / 7 LEU A 164
ALA A 182
GLY A 185
PHE A 161
 None
 0.89A 2wq5A-5sy1A:
undetectable		 2wq5A-5sy1A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 5sy1 STRA6
(Danio
rerio) 		4 / 4 ILE A 520
GLN A 417
VAL A 521
PHE A 421
 CLR  A 701 (-4.9A)
None
None
None
 1.47A 3ieoA-5sy1A:
undetectable		 3ieoA-5sy1A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 5sy1 STRA6
(Danio
rerio) 		4 / 7 GLU A  37
TYR A 135
TYR A 131
PHE A 113
 None
 1.20A 3ku9B-5sy1A:
undetectable		 3ku9B-5sy1A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 5sy1 STRA6
(Danio
rerio) 		4 / 4 ILE A 520
ASN A 519
ILE A 514
VAL A 513
 CLR  A 701 (-4.9A)
CLR  A 701 (-3.5A)
None
None
 1.30A 4uy87-5sy1A:
undetectable		 4uy87-5sy1A:
2.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5sy1 STRA6
(Danio
rerio) 		5 / 12 VAL A 559
GLY A 565
TYR A 225
TYR A 228
SER A 570
 None
 1.46A 4xueB-5sy1A:
undetectable		 4xueB-5sy1A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_A_ACTA403_0
(3C-LIKE PROTEINASE)		 5sy1 STRA6
(Danio
rerio) 		4 / 5 TYR A 548
SER A 278
LEU A 275
GLN A 406
 None
 1.36A 4yo9A-5sy1A:
undetectable
4yo9B-5sy1A:
undetectable		 4yo9A-5sy1A:
20.60
4yo9B-5sy1A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 5sy1 STRA6
(Danio
rerio) 		4 / 7 ILE A 528
HIS A 522
LEU A 530
GLY A 524
 None
 1.04A 4z69A-5sy1A:
2.1		 4z69A-5sy1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 5sy1 STRA6
(Danio
rerio) 		4 / 5 LEU A 357
LEU A 358
MET A 414
TYR A 287
 None
 1.27A 5uc3A-5sy1A:
undetectable		 5uc3A-5sy1A:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5sy1 STRA6
(Danio
rerio) 		5 / 10 LEU A 196
VAL A  91
VAL A  96
GLY A  95
LEU A  89
 None
 1.19A 6bsgA-5sy1A:
undetectable		 6bsgA-5sy1A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5sy1 STRA6
(Danio
rerio) 		4 / 6 VAL A  96
LEU A 193
LEU A 164
TYR A 131
 None
 1.02A 6f6sA-5sy1A:
undetectable
6f6sB-5sy1A:
undetectable		 6f6sA-5sy1A:
8.40
6f6sB-5sy1A:
7.29