SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5sy5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Mus
musculus)
5 / 11 LEU A 225
VAL A 179
GLY A 184
THR A 208
VAL A 213
None
1.13A 1akdA-5sy5A:
undetectable
1akdA-5sy5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Mus
musculus)
5 / 11 PHE A 263
VAL A 179
GLY A 184
THR A 208
VAL A 213
None
1.13A 1akdA-5sy5A:
undetectable
1akdA-5sy5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus;
Mus
musculus)
5 / 10 ALA A 172
VAL B 182
LEU B 198
HIS B 289
PHE B 149
None
1.34A 1aqbA-5sy5A:
undetectable
1aqbA-5sy5A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
5 / 12 ALA B 152
TRP B 108
LEU B 287
ILE B 142
LEU A 159
None
1.19A 1errA-5sy5B:
undetectable
1errA-5sy5B:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA8_0
(GRAMICIDIN C)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 5 GLY B 345
VAL B 343
TRP B 371
TRP B 380
None
1.46A 1nt6A-5sy5B:
undetectable
1nt6A-5sy5B:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB8_0
(GRAMICIDIN C)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 5 GLY B 345
VAL B 343
TRP B 371
TRP B 380
None
1.46A 1nt6B-5sy5B:
undetectable
1nt6B-5sy5B:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Mus
musculus)
5 / 11 LEU A 225
VAL A 179
GLY A 184
THR A 208
VAL A 213
None
1.08A 1phgA-5sy5A:
undetectable
1phgA-5sy5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Mus
musculus)
5 / 11 PHE A 263
VAL A 179
GLY A 184
THR A 208
VAL A 213
None
1.09A 1phgA-5sy5A:
undetectable
1phgA-5sy5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 8 ILE B 271
ASP B 147
GLY B 148
PHE B 149
None
0.78A 1rtsA-5sy5B:
undetectable
1rtsA-5sy5B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 7 ILE B 271
ASP B 147
GLY B 148
PHE B 149
None
0.86A 1rtsB-5sy5B:
undetectable
1rtsB-5sy5B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus;
Mus
musculus)
3 / 3 ASP A 161
GLU B 164
TYR B  94
None
0.84A 1wsvA-5sy5A:
undetectable
1wsvA-5sy5A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 7 ILE B 271
ASP B 147
GLY B 148
PHE B 149
None
0.83A 2tsrA-5sy5B:
undetectable
2tsrA-5sy5B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 8 PHE B 159
GLU B 176
SER B 173
VAL B 166
None
1.06A 3jx1A-5sy5B:
undetectable
3jx1B-5sy5B:
undetectable
3jx1A-5sy5B:
20.44
3jx1B-5sy5B:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 8 GLY B 140
ILE A 178
CYH A 336
PHE A 335
None
0.97A 3ko0K-5sy5B:
undetectable
3ko0S-5sy5B:
undetectable
3ko0K-5sy5B:
14.73
3ko0S-5sy5B:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 5 VAL B 365
GLU B 298
LYS B 269
PHE B 249
None
1.19A 3rv5C-5sy5B:
undetectable
3rv5D-5sy5B:
undetectable
3rv5C-5sy5B:
12.63
3rv5D-5sy5B:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
5 / 12 THR B 315
SER B 338
TYR B 340
SER B 311
VAL B 399
None
1.34A 3u9fD-5sy5B:
undetectable
3u9fE-5sy5B:
undetectable
3u9fD-5sy5B:
17.78
3u9fE-5sy5B:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
5 / 11 THR B 315
SER B 338
TYR B 340
SER B 311
VAL B 399
None
1.37A 3u9fM-5sy5B:
undetectable
3u9fO-5sy5B:
undetectable
3u9fM-5sy5B:
17.78
3u9fO-5sy5B:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
5 / 12 LEU B 356
ALA B 385
ILE B 351
LEU B 314
VAL B 399
None
1.16A 3w67C-5sy5B:
undetectable
3w67C-5sy5B:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
5 / 12 LEU B 356
VAL B 387
ILE B 351
LEU B 314
VAL B 399
None
1.01A 3w68B-5sy5B:
undetectable
3w68B-5sy5B:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3H_A_HQEA303_1
(CARBONIC ANHYDRASE 2)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Mus
musculus)
5 / 10 PHE A 263
VAL A 218
LEU A 209
THR A 208
VAL A 213
None
0.95A 4e3hA-5sy5A:
undetectable
4e3hA-5sy5A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 7 VAL B 343
SER B 383
TYR B 369
LEU B 314
None
0.95A 4hxyB-5sy5B:
undetectable
4hxyB-5sy5B:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_B_D16B402_1
(THYMIDYLATE SYNTHASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 7 ILE B 271
ASP B 147
GLY B 148
PHE B 149
None
0.79A 4iqqB-5sy5B:
undetectable
4iqqB-5sy5B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IQQ_C_D16C402_1
(THYMIDYLATE SYNTHASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 7 ILE B 271
ASP B 147
GLY B 148
PHE B 149
None
0.83A 4iqqC-5sy5B:
undetectable
4iqqC-5sy5B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
5 / 12 LEU A 343
GLY A 174
LEU B 146
HIS B 289
THR B 274
None
1.12A 4olmA-5sy5A:
undetectable
4olmA-5sy5A:
21.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus;
Mus
musculus)
6 / 7 ARG A 266
VAL A 305
TRP B 380
LEU B 406
SER B 407
GLU B 410
None
0.64A 4zphA-5sy5A:
10.7
4zphB-5sy5A:
11.0
4zphA-5sy5A:
100.00
4zphB-5sy5A:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus;
Mus
musculus)
3 / 3 GLU A 223
HIS B 302
ASP A 217
None
0.81A 5c0oG-5sy5A:
undetectable
5c0oG-5sy5A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus;
Mus
musculus)
5 / 12 LEU A 408
PHE A 427
VAL A 425
PHE A 363
GLY B 345
None
1.17A 5f9zB-5sy5A:
undetectable
5f9zB-5sy5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 8 HIS B 272
GLN A 344
LEU B 291
THR A 309
None
1.08A 5hs6A-5sy5B:
undetectable
5hs6A-5sy5B:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 7 ILE B 271
ASP B 147
GLY B 148
PHE B 149
None
0.78A 5nooA-5sy5B:
undetectable
5nooA-5sy5B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_B_D16B402_1
(THYMIDYLATE SYNTHASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 7 ILE B 271
ASP B 147
GLY B 148
PHE B 149
None
0.85A 5nooB-5sy5B:
undetectable
5nooB-5sy5B:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 7 ILE B 271
ASP B 147
GLY B 148
PHE B 149
None
0.83A 5x5qC-5sy5B:
undetectable
5x5qC-5sy5B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 8 ILE B 271
ASP B 147
GLY B 148
PHE B 149
None
0.81A 5x5qD-5sy5B:
undetectable
5x5qD-5sy5B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 8 ILE B 271
ASP B 147
GLY B 148
PHE B 149
None
0.81A 5x5qF-5sy5B:
undetectable
5x5qF-5sy5B:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Mus
musculus)
4 / 5 GLU A 362
PHE A 363
ASP A 377
THR A 383
None
1.33A 6b58A-5sy5A:
undetectable
6b58A-5sy5A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 7 ARG B  99
ARG B  98
LEU B  97
ALA B 152
None
1.19A 6b89A-5sy5B:
undetectable
6b89A-5sy5B:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXM_A_SAMA402_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus;
Mus
musculus)
5 / 12 LEU B 172
SER A 157
GLN B 174
LEU B  72
ILE B  78
None
1.20A 6bxmA-5sy5B:
undetectable
6bxmA-5sy5B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Mus
musculus)
5 / 9 VAL A 304
HIS A 302
ARG A 266
VAL A 218
ASP A 217
None
1.37A 6c2mA-5sy5A:
undetectable
6c2mA-5sy5A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Mus
musculus)
5 / 9 VAL A 304
HIS A 302
LEU A 209
ARG A 266
ASP A 217
None
1.37A 6c2mC-5sy5A:
undetectable
6c2mC-5sy5A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 5 LEU A 167
LEU B 143
THR A 160
PRO B  75
None
1.10A 6ew0F-5sy5A:
undetectable
6ew0F-5sy5A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus
musculus)
4 / 8 VAL B  92
GLN B 155
ASN B 154
GLU B 156
None
0.77A 6hzpA-5sy5B:
undetectable
6hzpA-5sy5B:
22.35