SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5sym'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 12 ILE A 222
GLY A 116
VAL A  24
ALA A 123
GLY A 138
 None
 0.86A 1kiaA-5symA:
2.9		 1kiaA-5symA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 12 ILE A 222
GLY A 116
VAL A  24
ALA A 123
GLY A 138
 None
 0.86A 1kiaB-5symA:
2.7		 1kiaB-5symA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 12 ILE A 222
GLY A 116
VAL A  24
ALA A 123
GLY A 138
 None
 0.87A 1kiaC-5symA:
2.8		 1kiaC-5symA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 12 ILE A 222
GLY A 116
VAL A  24
GLY A 138
LEU A 192
 None
 0.98A 1kiaC-5symA:
2.8		 1kiaC-5symA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 12 ILE A 222
GLY A 116
VAL A  24
ALA A 123
GLY A 138
 None
 0.89A 1nbhB-5symA:
2.7		 1nbhB-5symA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 12 ILE A 222
GLY A 116
VAL A  24
GLY A 138
LEU A 192
 None
 0.99A 1nbhB-5symA:
2.7		 1nbhB-5symA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 12 ILE A 222
GLY A 116
VAL A  24
ALA A 123
GLY A 138
 None
 1.04A 1nbiA-5symA:
2.1		 1nbiA-5symA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 12 ILE A 222
GLY A 116
VAL A  24
ALA A 123
GLY A 138
 None
 1.03A 1nbiB-5symA:
2.6		 1nbiB-5symA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		4 / 7 VAL A  24
TYR A  51
ILE A  44
ASP A 223
 None
 1.17A 2x45B-5symA:
undetectable		 2x45B-5symA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		4 / 7 VAL A  24
TYR A  51
ILE A  44
ASP A 223
 None
 1.17A 2x45C-5symA:
undetectable		 2x45C-5symA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 12 LEU A 189
ILE A 164
ILE A 166
PHE A 221
ILE A 100
 None
 0.97A 2ygoA-5symA:
undetectable		 2ygoA-5symA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 12 LEU A  99
GLU A 103
LEU A 136
LEU A 115
GLY A 116
 None
 1.22A 3g1uA-5symA:
2.3		 3g1uA-5symA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 12 LEU A  99
GLU A 103
LEU A 136
LEU A 115
GLY A 116
 None
 1.22A 3g1uC-5symA:
undetectable		 3g1uC-5symA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		4 / 4 LYS A  97
ASP A  85
GLU A  94
THR A 131
 EDO  A 304 (-2.8A)
None
EDO  A 304 ( 4.4A)
None
 1.47A 5d4uA-5symA:
undetectable		 5d4uA-5symA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		4 / 4 LYS A  97
ASP A  85
GLU A  94
THR A 131
 EDO  A 304 (-2.8A)
None
EDO  A 304 ( 4.4A)
None
 1.48A 5d4uB-5symA:
undetectable		 5d4uB-5symA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		4 / 4 LYS A  97
ASP A  85
GLU A  94
THR A 131
 EDO  A 304 (-2.8A)
None
EDO  A 304 ( 4.4A)
None
 1.49A 5d4uC-5symA:
undetectable		 5d4uC-5symA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN MJ0489)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		4 / 4 LYS A  97
ASP A  85
GLU A  94
THR A 131
 EDO  A 304 (-2.8A)
None
EDO  A 304 ( 4.4A)
None
 1.46A 5d4uD-5symA:
undetectable		 5d4uD-5symA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 11 THR A 128
ALA A 129
GLY A 121
GLY A 122
ALA A 123
 None
 0.93A 5lf3K-5symA:
undetectable
5lf3L-5symA:
undetectable		 5lf3K-5symA:
19.41
5lf3L-5symA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 11 THR A 128
ALA A 129
GLY A 121
GLY A 122
ALA A 123
 None
 0.94A 5lf3Y-5symA:
undetectable
5lf3Z-5symA:
undetectable		 5lf3Y-5symA:
19.41
5lf3Z-5symA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_D_CCSD14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2
PROGRAMMED CELL
DEATH 1 LIGAND 1)		 5sym ACYL-PROTEIN
THIOESTERASE 1
(Homo
sapiens) 		5 / 12 LEU A 142
GLY A 121
GLY A 116
VAL A 139
THR A 140
 None
 1.32A 5o4yD-5symA:
undetectable
5o4yE-5symA:
undetectable		 5o4yD-5symA:
18.37
5o4yE-5symA:
18.88