SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5syn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5syn ACYL-PROTEIN
THIOESTERASE 2
(Homo
sapiens) 		5 / 12 VAL A 220
VAL A  27
LEU A  44
GLY A 141
LEU A 224
 None
 1.01A 1eqhA-5synA:
undetectable		 1eqhA-5synA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5syn ACYL-PROTEIN
THIOESTERASE 2
(Homo
sapiens) 		5 / 12 VAL A 220
VAL A  27
LEU A  44
GLY A 141
LEU A 224
 None
 0.98A 1eqhB-5synA:
undetectable		 1eqhB-5synA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5syn ACYL-PROTEIN
THIOESTERASE 2
(Homo
sapiens) 		5 / 12 LEU A  78
GLY A  34
GLY A  32
LEU A  30
GLY A 120
 71T  A 301 ( 3.7A)
None
None
None
None
 0.87A 1y4lA-5synA:
undetectable		 1y4lA-5synA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5syn ACYL-PROTEIN
THIOESTERASE 2
(Homo
sapiens) 		5 / 12 VAL A 220
VAL A  27
LEU A  44
GLY A 141
LEU A 224
 None
 0.95A 3n8wA-5synA:
undetectable		 3n8wA-5synA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5syn ACYL-PROTEIN
THIOESTERASE 2
(Homo
sapiens) 		5 / 12 VAL A 220
VAL A  27
LEU A  44
GLY A 141
LEU A 224
 None
 0.97A 3n8zA-5synA:
undetectable		 3n8zA-5synA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5syn ACYL-PROTEIN
THIOESTERASE 2
(Homo
sapiens) 		5 / 10 ALA A 159
LEU A 133
ALA A 144
ALA A 188
THR A 187
 None
None
None
None
71T  A 301 (-3.3A)
 1.02A 4j14A-5synA:
undetectable		 4j14A-5synA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5syn ACYL-PROTEIN
THIOESTERASE 2
(Homo
sapiens) 		5 / 10 VAL A 220
VAL A  27
LEU A  44
GLY A 141
LEU A 224
 None
 0.96A 4ph9A-5synA:
undetectable		 4ph9A-5synA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5syn ACYL-PROTEIN
THIOESTERASE 2
(Homo
sapiens) 		5 / 10 VAL A 220
VAL A  27
LEU A  44
GLY A 141
LEU A 224
 None
 0.97A 4ph9B-5synA:
undetectable		 4ph9B-5synA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5syn ACYL-PROTEIN
THIOESTERASE 2
(Homo
sapiens) 		5 / 12 VAL A 220
LEU A 224
LEU A 118
GLY A 119
LEU A 145
 None
 1.00A 4rrwC-5synA:
undetectable		 4rrwC-5synA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5syn ACYL-PROTEIN
THIOESTERASE 2
(Homo
sapiens) 		5 / 12 VAL A 220
LEU A 224
LEU A 118
GLY A 119
LEU A 145
 None
 1.00A 4rrzC-5synA:
undetectable		 4rrzC-5synA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5syn ACYL-PROTEIN
THIOESTERASE 2
(Homo
sapiens) 		5 / 11 THR A 131
ALA A 132
GLY A 124
GLY A 125
ALA A 126
 None
 0.99A 5lf3K-5synA:
undetectable
5lf3L-5synA:
undetectable		 5lf3K-5synA:
22.61
5lf3L-5synA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5syn ACYL-PROTEIN
THIOESTERASE 2
(Homo
sapiens) 		5 / 11 THR A 131
ALA A 132
GLY A 124
GLY A 125
ALA A 126
 None
 1.00A 5lf3Y-5synA:
undetectable
5lf3Z-5synA:
undetectable		 5lf3Y-5synA:
22.61
5lf3Z-5synA:
22.32