SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5syt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		5 / 12 LEU A 185
LEU A 179
GLN A 175
LEU A 388
THR A 204
 None
None
None
CXE  A 504 ( 3.3A)
CXE  A 504 ( 3.8A)
 1.39A 1a28B-5sytA:
undetectable		 1a28B-5sytA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1869_0
(FPRA)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		4 / 4 ASP A 419
HIS A 335
ARG A 465
GLU A 415
 None
ZN  A 517 (-3.2A)
None
ZN  A 517 (-2.1A)
 0.87A 1lqtA-5sytA:
undetectable		 1lqtA-5sytA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1426_0
(FPRA)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		4 / 4 ASP A 419
HIS A 335
ARG A 465
GLU A 415
 None
ZN  A 517 (-3.2A)
None
ZN  A 517 (-2.1A)
 0.81A 1lquA-5sytA:
undetectable		 1lquA-5sytA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		3 / 3 ASP A 281
PHE A 226
ASN A 265
 DMS  A 521 ( 4.9A)
None
None
 0.73A 1sg9B-5sytA:
undetectable		 1sg9B-5sytA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		5 / 8 GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
 1.26A 1v7zA-5sytA:
undetectable		 1v7zA-5sytA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		5 / 8 GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
 1.26A 1v7zB-5sytA:
undetectable		 1v7zB-5sytA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		5 / 8 GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
 1.27A 1v7zC-5sytA:
undetectable		 1v7zC-5sytA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		5 / 8 GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
 1.26A 1v7zD-5sytA:
undetectable		 1v7zD-5sytA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		5 / 8 GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
 1.26A 1v7zE-5sytA:
undetectable		 1v7zE-5sytA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		5 / 8 GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
 1.24A 3a6jA-5sytA:
undetectable		 3a6jA-5sytA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		5 / 8 GLU A 415
HIS A 335
HIS A 459
HIS A 339
GLU A 336
 ZN  A 517 (-2.1A)
ZN  A 517 (-3.2A)
DMS  A 523 (-4.3A)
ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
 1.24A 3a6jC-5sytA:
undetectable		 3a6jC-5sytA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		4 / 6 PHE A 108
ALA A 112
GLY A 110
TYR A 111
 None
 1.14A 3dd1B-5sytA:
undetectable		 3dd1B-5sytA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		3 / 3 HIS A 335
GLU A 336
HIS A 339
 ZN  A 517 (-3.2A)
ZN  A 517 (-3.9A)
ZN  A 517 (-3.2A)
 0.22A 3kecB-5sytA:
undetectable		 3kecB-5sytA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		4 / 6 GLY A 257
VAL A 255
ASP A 281
THR A 282
 None
None
DMS  A 521 ( 4.9A)
None
 1.20A 3vqrA-5sytA:
undetectable		 3vqrA-5sytA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		4 / 5 GLY A 257
VAL A 255
ASP A 281
THR A 282
 None
None
DMS  A 521 ( 4.9A)
None
 1.21A 3vqrB-5sytA:
undetectable		 3vqrB-5sytA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		4 / 6 GLU A 150
TYR A  70
LEU A 443
PHE A 155
 None
 1.03A 4twdI-5sytA:
undetectable
4twdJ-5sytA:
undetectable		 4twdI-5sytA:
20.82
4twdJ-5sytA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B54_A_OAQA302_0
(SULFOTRANSFERASE)		 5syt CAAX PRENYL PROTEASE
1 HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A  19
LEU A  24
LEU A 372
PHE A 376
LEU A 366
 C8E  A 513 ( 3.8A)
None
C8E  A 513 ( 4.7A)
None
C8E  A 513 ( 4.7A)
 1.03A 6b54A-5sytA:
undetectable		 6b54A-5sytA:
22.41