SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5sz8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5sz8 HEMOLYSIN
(Proteus
mirabilis) 		5 / 12 ASN A  66
VAL A 135
PHE A  80
VAL A  43
ILE A  32
 None
 1.45A 3elzC-5sz8A:
undetectable		 3elzC-5sz8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5sz8 HEMOLYSIN
(Proteus
mirabilis) 		4 / 7 GLY A  77
GLN A  51
VAL A  73
ILE A 150
 None
 0.88A 3fi0P-5sz8A:
undetectable		 3fi0P-5sz8A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5sz8 HEMOLYSIN
(Proteus
mirabilis) 		5 / 12 ASN A  96
ALA A  92
GLY A  93
ASN A  47
GLY A  77
 None
 1.23A 4obwA-5sz8A:
undetectable		 4obwA-5sz8A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5sz8 HEMOLYSIN
(Proteus
mirabilis) 		5 / 11 ILE A  32
PHE A  71
SER A  64
ILE A 109
ILE A  53
 None
 1.23A 4p68A-5sz8A:
undetectable		 4p68A-5sz8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5sz8 HEMOLYSIN
(Proteus
mirabilis) 		5 / 11 GLY A 205
ALA A 209
ILE A 212
LEU A 196
LEU A 157
 None
 0.95A 4xumB-5sz8A:
undetectable		 4xumB-5sz8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5sz8 HEMOLYSIN
(Proteus
mirabilis) 		4 / 6 LEU A 163
ASN A 161
PRO A 162
ARG A 154
 None
 1.42A 4yv5A-5sz8A:
undetectable		 4yv5A-5sz8A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 5sz8 HEMOLYSIN
(Proteus
mirabilis) 		4 / 7 LEU A 183
THR A 190
THR A 191
LEU A 181
 None
 1.05A 5jq7B-5sz8A:
undetectable		 5jq7B-5sz8A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5sz8 HEMOLYSIN
(Proteus
mirabilis) 		5 / 12 ILE A 109
VAL A  56
TYR A  68
GLY A 160
TYR A 172
 None
 1.04A 5uxdB-5sz8A:
undetectable		 5uxdB-5sz8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5sz8 HEMOLYSIN
(Proteus
mirabilis) 		5 / 12 LEU A 181
VAL A 159
PHE A 149
ALA A 125
GLY A  77
 None
 1.11A 5uxdB-5sz8A:
undetectable		 5uxdB-5sz8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 5sz8 HEMOLYSIN
(Proteus
mirabilis) 		5 / 12 LEU A  84
LEU A 101
ILE A 109
SER A  64
ALA A 106
 None
 1.24A 6n91A-5sz8A:
undetectable		 6n91A-5sz8A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 5sz8 HEMOLYSIN
(Proteus
mirabilis) 		5 / 12 LEU A  84
LEU A 101
ILE A 109
SER A  64
ALA A 106
 None
 1.29A 6n91B-5sz8A:
undetectable		 6n91B-5sz8A:
19.44