SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5szi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5szi RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		5 / 12 ASN A 160
MET A 117
LEU A 119
ILE A  61
LEU A  13
 None
 1.11A 1lhuA-5sziA:
undetectable		 1lhuA-5sziA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5szi RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		4 / 8 THR A  64
THR A  22
GLY A  15
VAL A  87
 None
MG  A 302 ( 2.8A)
None
None
 0.82A 4qvvK-5sziA:
undetectable
4qvvL-5sziA:
undetectable		 4qvvK-5sziA:
21.21
4qvvL-5sziA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5szi RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		4 / 8 THR A  64
THR A  22
GLY A  15
VAL A  87
 None
MG  A 302 ( 2.8A)
None
None
 0.82A 4qvvY-5sziA:
undetectable
4qvvZ-5sziA:
undetectable		 4qvvY-5sziA:
21.21
4qvvZ-5sziA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 5szi RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		5 / 9 TYR A  78
LEU A  12
THR A  64
ILE A  43
GLY A  42
 None
 1.42A 5ifuB-5sziA:
3.4		 5ifuB-5sziA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5szi RAS-RELATED PROTEIN
RAB-8A
(Homo
sapiens) 		4 / 4 VAL A 131
LEU A 139
ASN A  92
ASP A  89
 None
 1.18A 5vcyA-5sziA:
undetectable		 5vcyA-5sziA:
19.87