SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5szp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
5 / 10 VAL A  56
LEU A  11
SER A   6
VAL A  91
PHE A  45
None
1.35A 1fdwA-5szpA:
undetectable
1fdwA-5szpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
4 / 6 THR A 193
ASP A 186
ASN A 135
ASP A  95
MAN  A 510 ( 1.9A)
CA  A 503 (-3.5A)
None
CA  A 502 (-3.3A)
1.33A 2okcA-5szpA:
undetectable
2okcA-5szpA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
5 / 11 LEU A 110
ILE A 200
PHE A 148
LEU A 170
ASP A 116
None
1.15A 2q6hA-5szpA:
undetectable
2q6hA-5szpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
5 / 12 LEU A 110
ILE A 200
PHE A 148
LEU A 170
ASP A 116
None
1.14A 2qb4A-5szpA:
undetectable
2qb4A-5szpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA801_1
(TRANSPORTER)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
5 / 11 LEU A 110
ILE A 200
PHE A 148
LEU A 170
ASP A 116
None
1.13A 2qeiA-5szpA:
undetectable
2qeiA-5szpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
5 / 11 LEU A 110
ILE A 200
PHE A 148
LEU A 170
ASP A 116
None
1.16A 2qjuA-5szpA:
undetectable
2qjuA-5szpA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_1
(UNCHARACTERIZED
PROTEIN PH0793)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
3 / 3 MET A 169
GLU A 173
ASP A 238
None
CA  A 505 ( 2.4A)
CA  A 506 (-2.2A)
1.09A 3a25A-5szpA:
undetectable
3a25A-5szpA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
4 / 5 VAL A 202
VAL A 203
THR A 177
ARG A 201
None
1.16A 3bjwA-5szpA:
undetectable
3bjwA-5szpA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
4 / 5 VAL A 202
VAL A 203
THR A 177
ARG A 201
None
1.20A 3bjwC-5szpA:
undetectable
3bjwC-5szpA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
4 / 5 ASP A 310
ASP A 307
ASP A 343
ARG A 342
CA  A 507 ( 2.3A)
CA  A 508 (-3.3A)
CA  A 508 ( 3.0A)
None
1.05A 3naiA-5szpA:
undetectable
3naiA-5szpA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
4 / 5 ASP A 310
ASP A 307
ASP A 343
ARG A 342
CA  A 507 ( 2.3A)
CA  A 508 (-3.3A)
CA  A 508 ( 3.0A)
None
1.10A 3naiC-5szpA:
undetectable
3naiC-5szpA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
4 / 7 ILE A 200
PHE A 148
LEU A 170
ASP A 116
None
0.79A 4mmcA-5szpA:
undetectable
4mmcA-5szpA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)
5szp PROTOCADHERIN GAMMA
B7

(Mus
musculus)
4 / 6 GLU A 114
ARG A 172
GLU A 175
ALA A 174
CA  A 505 ( 2.9A)
CA  A 505 ( 4.8A)
None
None
1.16A 6an0A-5szpA:
undetectable
6an0A-5szpA:
20.92