SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5szq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 5szq PROTOCADHERIN
GAMMA-A4
(Mus
musculus) 		5 / 11 LEU A 306
VAL A 307
ILE A 273
VAL A 291
PHE A 253
 None
 1.33A 1gx9A-5szqA:
undetectable		 1gx9A-5szqA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 5szq PROTOCADHERIN
GAMMA-A4
(Mus
musculus) 		4 / 6 SER A 348
ASN A 313
LEU A 404
ASP A 398
 None
CA  A 712 (-3.2A)
None
CA  A 712 (-2.9A)
 1.33A 1mxdA-5szqA:
undetectable		 1mxdA-5szqA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 5szq PROTOCADHERIN
GAMMA-A4
(Mus
musculus) 		5 / 12 LEU A 463
ARG A 507
ILE A 460
ILE A 479
TYR A 429
 None
 1.47A 1ot7B-5szqA:
undetectable		 1ot7B-5szqA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEO_A_017A402_2
(PROTEASE)		 5szq PROTOCADHERIN
GAMMA-A4
(Mus
musculus) 		5 / 12 ALA A 396
VAL A 343
ILE A 358
VAL A 321
VAL A 319
 None
 0.85A 2ieoB-5szqA:
undetectable		 2ieoB-5szqA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5szq PROTOCADHERIN
GAMMA-A4
(Mus
musculus) 		5 / 12 ILE A 392
ILE A 410
LEU A 376
VAL A 321
ILE A 378
 None
 1.00A 2nnhA-5szqA:
undetectable		 2nnhA-5szqA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 5szq PROTOCADHERIN
GAMMA-A4
(Mus
musculus) 		4 / 8 ASP A 383
ASP A 508
ASN A 420
GLU A 330
 CA  A 713 (-2.6A)
CA  A 715 (-3.6A)
CA  A 713 (-4.1A)
CA  A 714 ( 2.8A)
 0.90A 4gkiE-5szqA:
undetectable
4gkiG-5szqA:
undetectable		 4gkiE-5szqA:
20.40
4gkiG-5szqA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 5szq PROTOCADHERIN
GAMMA-A4
(Mus
musculus) 		4 / 6 GLY A 484
THR A 483
SER A 445
VAL A 485
 None
None
MAN  A 706 ( 2.7A)
None
 1.06A 5ewuA-5szqA:
undetectable		 5ewuA-5szqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5szq PROTOCADHERIN
GAMMA-A4
(Mus
musculus) 		3 / 3 ARG A 365
ILE A 378
PHE A 364
 None
 0.60A 5kirA-5szqA:
undetectable		 5kirA-5szqA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5szq PROTOCADHERIN
GAMMA-A4
(Mus
musculus) 		3 / 3 LYS A 562
LEU A 559
ARG A 599
 None
 0.88A 5yw0A-5szqA:
undetectable		 5yw0A-5szqA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 5szq PROTOCADHERIN
GAMMA-A4
(Mus
musculus) 		3 / 3 PRO A 472
SER A 474
SER A 475
 None
 0.49A 6bpyA-5szqA:
undetectable		 6bpyA-5szqA:
20.94