SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5szr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5szr PROTEIN PCDHGB2
(Mus
musculus) 		5 / 11 PHE A 545
LEU A 630
ALA A 628
VAL A 596
TYR A 534
 None
 1.47A 1qabE-5szrA:
undetectable		 1qabE-5szrA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5szr PROTEIN PCDHGB2
(Mus
musculus) 		3 / 3 SER A 458
ASP A 480
ASP A 506
 None
None
CA  A 712 (-3.5A)
 0.88A 3iv6C-5szrA:
undetectable		 3iv6C-5szrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5szr PROTEIN PCDHGB2
(Mus
musculus) 		3 / 3 GLN A 503
THR A 501
ASN A 515
 NAG  A 705 (-4.5A)
None
NAG  A 705 (-1.7A)
 0.74A 3v4tE-5szrA:
undetectable		 3v4tE-5szrA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 5szr PROTEIN PCDHGB2
(Mus
musculus) 		4 / 6 VAL A 484
LEU A 502
ILE A 461
VAL A 520
 None
 0.89A 4a9kA-5szrA:
undetectable		 4a9kA-5szrA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5szr PROTEIN PCDHGB2
(Mus
musculus) 		6 / 12 GLY A 594
GLY A 590
LEU A 574
SER A 575
VAL A 561
VAL A 532
 None
 1.47A 4htfA-5szrA:
undetectable		 4htfA-5szrA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5szr PROTEIN PCDHGB2
(Mus
musculus) 		6 / 12 GLY A 594
GLY A 590
LEU A 574
SER A 575
VAL A 561
VAL A 532
 None
 1.50A 4htfA-5szrA:
undetectable		 4htfA-5szrA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 5szr PROTEIN PCDHGB2
(Mus
musculus) 		4 / 4 VAL A 406
ALA A 394
ILE A 318
THR A 341
 None
 1.16A 5e4dB-5szrA:
undetectable		 5e4dB-5szrA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5szr PROTEIN PCDHGB2
(Mus
musculus) 		4 / 6 LEU A 374
CYH A 354
HIS A 355
LEU A 364
 None
 1.10A 5hpuC-5szrA:
undetectable
5hpuD-5szrA:
undetectable		 5hpuC-5szrA:
4.94
5hpuD-5szrA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5szr PROTEIN PCDHGB2
(Mus
musculus) 		4 / 6 VAL A 258
VAL A 289
SER A 302
PHE A 217
 None
 1.05A 5jw1B-5szrA:
undetectable		 5jw1B-5szrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5szr PROTEIN PCDHGB2
(Mus
musculus) 		4 / 8 GLN A 494
ASN A 528
ALA A 566
SER A 568
 None
CA  A 713 (-4.9A)
None
None
 1.07A 5km8A-5szrA:
undetectable
5km8B-5szrA:
undetectable		 5km8A-5szrA:
16.10
5km8B-5szrA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5szr PROTEIN PCDHGB2
(Mus
musculus) 		3 / 3 LYS A 560
LEU A 557
ARG A 597
 None
 0.87A 5yw0A-5szrA:
undetectable		 5yw0A-5szrA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5szr PROTEIN PCDHGB2
(Mus
musculus) 		3 / 3 ILE A 247
THR A 248
PRO A 210
 None
 0.62A 6ncsA-5szrA:
undetectable		 6ncsA-5szrA:
21.19