SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5t03'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
4 / 6 VAL A   8
VAL A  50
ILE A  60
ASN A 267
None
0.98A 1e06A-5t03A:
undetectable
1e06A-5t03A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
4 / 4 LYS A1288
LEU A1284
ALA A1287
LEU A1349
None
EDO  A1421 ( 4.8A)
None
None
1.41A 1f86A-5t03A:
undetectable
1f86A-5t03A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
4 / 4 LYS A1288
LEU A1284
ALA A1287
LEU A1349
None
EDO  A1421 ( 4.8A)
None
None
1.48A 1f86B-5t03A:
undetectable
1f86B-5t03A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
3 / 3 TYR A1308
ARG A1377
GLN A1374
None
0.86A 1tw4A-5t03A:
undetectable
1tw4A-5t03A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
5 / 9 LEU A1260
HIS A1158
HIS A1101
MET A1189
LEU A1190
None
GNS  A1402 ( 3.9A)
A3P  A1401 (-3.9A)
None
None
1.32A 2jihA-5t03A:
undetectable
2jihA-5t03A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA509_0
(CHORISMATE SYNTHASE)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
3 / 3 ARG A  66
GLN A1345
PRO A  48
GLC  A1410 (-3.8A)
None
None
0.96A 2qhfA-5t03A:
undetectable
2qhfA-5t03A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
4 / 6 PHE A 258
ALA A 162
LEU A 247
PRO A 159
None
0.94A 3bgdA-5t03A:
undetectable
3bgdA-5t03A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
4 / 7 VAL A 110
GLY A 300
PRO A 229
LYS A 305
None
0.74A 3bjwC-5t03A:
undetectable
3bjwC-5t03A:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_1
(N,N-DIMETHYLTRANSFER
ASE)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
3 / 3 TYR A1231
GLU A1200
ASP A1350
None
0.79A 3bxoA-5t03A:
undetectable
3bxoA-5t03A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
3 / 3 TYR A1231
GLU A1200
ASP A1350
None
0.86A 3bxoB-5t03A:
undetectable
3bxoB-5t03A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
3 / 3 ASN A 367
ASP A1359
GLN A1363
EDO  A1422 (-4.3A)
None
None
0.78A 3eeyC-5t03A:
undetectable
3eeyC-5t03A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
3 / 3 ASN A 367
ASP A1359
GLN A1363
EDO  A1422 (-4.3A)
None
None
0.79A 3eeyD-5t03A:
undetectable
3eeyD-5t03A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
3 / 3 ASN A 367
ASP A1359
GLN A1363
EDO  A1422 (-4.3A)
None
None
0.78A 3eeyE-5t03A:
undetectable
3eeyE-5t03A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
4 / 6 PRO A 126
LEU A 147
ALA A 223
PRO A 125
None
1.31A 3gv1A-5t03A:
undetectable
3gv1C-5t03A:
undetectable
3gv1A-5t03A:
11.67
3gv1C-5t03A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
5 / 12 VAL A 343
GLY A 187
ALA A 188
LEU A 192
LEU A 160
None
1.05A 3hs6A-5t03A:
undetectable
3hs6A-5t03A:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
12 / 12 ASP A  14
LYS A  15
LYS A  42
GLU A  44
GLU A  45
ALA A  63
ASP A  65
ARG A  66
GLU A 111
PRO A 154
TRP A 230
TYR A 341
GLC  A1412 ( 3.0A)
GLC  A1412 ( 2.7A)
GLC  A1409 (-3.3A)
GLC  A1409 ( 2.9A)
GLC  A1409 ( 3.7A)
GLC  A1411 ( 3.2A)
GLC  A1411 (-2.7A)
GLC  A1410 (-3.8A)
GLC  A1412 (-3.0A)
GLC  A1411 ( 3.6A)
GLC  A1412 ( 4.4A)
GLC  A1410 (-4.6A)
0.30A 3jyrA-5t03A:
62.7
3jyrA-5t03A:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
6 / 7 ASN A  12
TRP A  62
GLU A 153
TYR A 155
MET A 330
TRP A 340
GLC  A1412 ( 4.7A)
GLC  A1411 ( 4.3A)
GLC  A1410 ( 3.0A)
GLC  A1412 ( 3.8A)
GLC  A1411 (-4.2A)
GLC  A1411 ( 3.8A)
0.20A 3jyrA-5t03A:
62.7
3jyrA-5t03A:
56.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
6 / 7 ASN A  12
TRP A  62
TYR A 155
MET A 330
TRP A 340
ARG A 344
GLC  A1412 ( 4.7A)
GLC  A1411 ( 4.3A)
GLC  A1412 ( 3.8A)
GLC  A1411 (-4.2A)
GLC  A1411 ( 3.8A)
GLC  A1409 (-3.9A)
0.62A 3jyrA-5t03A:
62.7
3jyrA-5t03A:
56.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
4 / 4 ARG A 344
ASP A 184
GLY A 166
THR A 157
GLC  A1409 (-3.9A)
None
None
None
1.16A 3k4vB-5t03A:
undetectable
3k4vB-5t03A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
5 / 12 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
None
0.97A 3n8yB-5t03A:
undetectable
3n8yB-5t03A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
None
None
None
GLC  A1412 (-3.0A)
None
0.83A 3tbgB-5t03A:
undetectable
3tbgB-5t03A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
None
None
None
GLC  A1412 (-3.0A)
None
0.82A 3tbgD-5t03A:
undetectable
3tbgD-5t03A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
5 / 12 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
None
EDO  A1418 ( 4.0A)
None
None
None
1.32A 3vwqA-5t03A:
undetectable
3vwqA-5t03A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
4 / 5 ASN A 267
ALA A  51
GLY A  56
ASP A  14
None
None
None
GLC  A1412 ( 3.0A)
0.98A 4n48A-5t03A:
undetectable
4n48A-5t03A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
4 / 6 THR A1313
GLN A1122
LEU A1120
GLU A1121
None
0.87A 4nc3A-5t03A:
undetectable
4nc3A-5t03A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
None
1.12A 4or0B-5t03A:
undetectable
4or0B-5t03A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
3 / 3 ARG A1196
GLN A1103
GLU A1200
None
0.82A 4tvtA-5t03A:
undetectable
4tvtA-5t03A:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
5 / 12 GLY A1106
HIS A1113
GLU A1311
ILE A1187
PHE A1296
A3P  A1401 (-3.2A)
None
None
None
None
1.41A 5igwA-5t03A:
undetectable
5igwA-5t03A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
None
1.43A 5w4zA-5t03A:
undetectable
5w4zA-5t03A:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio
rerio;
Escherichia
coli)
6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
None
1.46A 5w4zB-5t03A:
undetectable
5w4zB-5t03A:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
3 / 3 TYR A 155
ASN A 227
LEU A 113
GLC  A1412 ( 3.8A)
None
None
0.81A 6b58A-5t03A:
undetectable
6b58A-5t03A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio
rerio)
5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
None
1.45A 6bm5A-5t03A:
undetectable
6bm5A-5t03A:
19.33